scholarly journals Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper

2020 ◽  
Vol 28 (4) ◽  
pp. 115301 ◽  
Author(s):  
Yulin Ren ◽  
Qingwei Tan ◽  
Kimberly Heath ◽  
Sijin Wu ◽  
James R. Wilson ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
Streblus Asper

Characterization, quantitation, similarity evaluation and combination with Na+,K+-ATPase of cardiac glycosides from Streblus asper

2019 ◽  
Vol 87 ◽  
pp. 265-275 ◽  
Author(s):  
Yidan Bai ◽  
Wanfang Zhu ◽  
Yunhui Xu ◽  
Zijian Xie ◽  
Toshihiro Akihisa ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
Streblus Asper

scholarly journals Three new cardiac glycosides obtained from the roots ofStreblus asperLour. and their cytotoxic and melanogenesis-inhibitory activities

RSC Advances ◽  
2018 ◽  
Vol 8 (35) ◽  
pp. 19570-19579 ◽  
Author(s):  
Dan Miao ◽  
Tengqian Zhang ◽  
Jian Xu ◽  
Congyu Ma ◽  
Wenyuan Liu ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extracts ◽  
Inhibitory Activities ◽  
Streblus Asper

The cardiac glycosides isolated from the methanol extracts ofStreblus asperLour. roots indicated potent cytotoxicities and high selective index, and the mechanism of melanogenesis-inhibition was explored.

Cardiac glycosides from the roots of Streblus asper Lour. and their apoptosis-inducing activities in A549 cells

2021 ◽  
Vol 181 ◽  
pp. 112544
Author(s):  
Bo-dou Zhang ◽  
Wan-fang Zhu ◽  
Toshihiro Akihisa ◽  
Takashi Kikuchi ◽  
Motohiko Ukiya ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
A549 Cells ◽  
Streblus Asper

Plant Anticancer Agents, XLI. Cardiac Glycosides from Streblus asper

1985 ◽  
Vol 48 (6) ◽  
pp. 981-985 ◽  
Author(s):  
Manfred Fiebig ◽  
Chang-Yih Duh ◽  
John M. Pezzuto ◽  
A. Douglas Kinghorn ◽  
Norman R. Farnsworth
Keyword(s):  
Anticancer Agents ◽  
Cardiac Glycosides ◽  
Streblus Asper

scholarly journals Interaction of (+)-Strebloside and Its Derivatives with Na+/K+-ATPase and Other Targets

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5675
Author(s):  
Yulin Ren ◽  
Sijin Wu ◽  
Sijie Chen ◽  
Joanna E. Burdette ◽  
Xiaolin Cheng ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Protein Interactions ◽  
Anticancer Agents ◽  
Cardiac Glycoside ◽  
Cardiac Glycosides ◽  
P53 Protein ◽  
Molecular Targets ◽  
Protein Protein Interactions ◽  
Negative Regulators ◽  
Streblus Asper

Docking profiles for (+)-strebloside, a cytotoxic cardiac glycoside identified from Streblus asper, and some of its derivatives and Na+/K+-ATPase have been investigated. In addition, binding between (+)-strebloside and its aglycone, strophanthidin, and several of their other molecular targets, including FIH-1, HDAC, KEAP1 and MDM2 (negative regulators of Nrf2 and p53, respectively), NF-κB, and PI3K and Akt1, have been inspected and compared with those for digoxin and its aglycone, digoxigenin. The results showed that (+)-strebloside, digoxin, and their aglycones bind to KEAP1 and MDM2, while (+)-strebloside, strophanthidin, and digoxigenin dock to the active pocket of PI3K, and (+)-strebloside and digoxin interact with FIH-1. Thus, these cardiac glycosides could directly target HIF-1, Nrf2, and p53 protein–protein interactions, Na+/K+-ATPase, and PI3K to mediate their antitumor activity. Overall, (+)-strebloside seems more promising than digoxin for the development of potential anticancer agents.

Cardiotonic steroids with potent cytotoxicity from Streblus Asper

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
Y Ren ◽  
TN Ninh ◽  
HB Chai ◽  
DD Soejarto ◽  
AD Kinghorn
Keyword(s):  
Streblus Asper

Characterization of non polar-polar solvent extracts from some tea plantation shade tree leaves with special reference to antioxidant and antibacterial activities

2020 ◽  
pp. 15-21
Author(s):  
Arindam Ghosh ◽  
Soumya Majumder ◽  
Sumedha Saha ◽  
Malay Bhattacharya
Keyword(s):  
Cardiac Glycosides ◽  
Polar Solvent ◽  
Reducing Power ◽  
Scavenging Activity ◽  
Shade Trees ◽  
Crude Fibre ◽  
Shade Tree ◽  
Dpph Scavenging Activity ◽  
Dpph Scavenging

Beneficial properties of shade trees of tea plantations other than their medicinal properties have been extensively studied. This research was initiated to explore the properties of some shade trees with special emphasis on their antioxidant and antibacterial properties. Leaves from shade tree like Dalbergia sissoo (DS), Cassia siamea (CS), Derris robusta (DR), Leucaena leucocephala (LL), Acacia lenticularis (AL) and Melia azedarach (MA) were used for the study. Characterization of shade tree leaves by determination of moisture, crude fibre and ash content and tests of non polar – polar solvent extracts for steroid, tannins, cardiac glycosides and coumarin, free radical scavenging, ferric reducing power, NO scavenging activities, quantification of Flavonoids and antibacterial activity were conducted. The average moisture, crude fibre and ash percentage of shade tree plants were found to be 62.95, 11.28 and 1.86 respectively. Methanol, ethanol, acetone and ethyl acetate respectively proved to be the most potent solvent for various phytochemical extractions as it gave positive results for tests like tannin, steroid, cardiac glycosides and coumarin. AL (91.46%), DR (92.69%), LL (94.32%) and MA (93.34%) leaf extracts showed a high level of DPPH scavenging activity in their water extracts. In DS (88.11%) and CS (83.23%) maximum DPPH scavenging activity was observed in Diethyl ether and Methanol extracts respectively.  Acetone extracts were more active than the water extracts in exhibiting ferric reducing power and NO scavenging activity. Summation of the quantity revealed that DS showed maximum presence of flavonoids and acetone as most potential for isolation of flavonoids. The decreasing order of summative antibacterial activity was recorded in DS, followed by CS, DR, AL, MA and LL. Chloroform showed the highest summative inhibition zone followed by ethanol, ethyl acetate, diethyl ether, acetone, water,  hexane, benzene and methanol. The antioxidant and antibacterial potential of shade trees were established.

Investigation of antiulcer activity of Pergularia extensa Linn

2020 ◽  
Vol 9 (2) ◽  
pp. 23-26
Author(s):  
Pavani C H
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Antiulcer Activity ◽  
Acute Oral Toxicity ◽  
Gastric Lesions ◽  
Oral Toxicity ◽  
Control Groups ◽  
Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively. 

Sign in / Sign up

Export Citation Format

Share Document