Cardiotonic steroids with potent cytotoxicity from Streblus Asper

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
Y Ren ◽  
TN Ninh ◽  
HB Chai ◽  
DD Soejarto ◽  
AD Kinghorn
Keyword(s):  
Streblus Asper

Streblus asper Lour. exerts MAPK and SKN-1 mediated anti-aging, anti-photoaging activities and imparts neuroprotection by ameliorating Aβ in Caenorhabditis elegans

2021 ◽  
pp. 1-17
Author(s):  
Mani Iyer Prasanth ◽  
James Michael Brimson ◽  
Dicson Sheeja Malar ◽  
Anchalee Prasansuklab ◽  
Tewin Tencomnao
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Vital Role ◽  
Transgenic Strain ◽  
Wild Type ◽  
Neuroprotective Effects ◽  
C Elegans ◽  
Streblus Asper

BACKGROUND: Streblus asper Lour., has been reported to have anti-aging and neuroprotective efficacies in vitro. OBJECTIVE: To analyze the anti-aging, anti-photoaging and neuroprotective efficacies of S. asper in Caenorhabditis elegans. METHODS: C. elegans (wild type and gene specific mutants) were treated with S. asper extract and analyzed for lifespan and other health benefits through physiological assays, fluorescence microscopy, qPCR and Western blot. RESULTS: The plant extract was found to increase the lifespan, reduce the accumulation of lipofuscin and modulate the expression of candidate genes. It could extend the lifespan of both daf-16 and daf-2 mutants whereas the pmk-1 mutant showed no effect. The activation of skn-1 was observed in skn-1::GFP transgenic strain and in qPCR expression. Further, the extract can extend the lifespan of UV-A exposed nematodes along with reducing ROS levels. Additionally, the extract also extends lifespan and reduces paralysis in Aβ transgenic strain, apart from reducing Aβ expression. CONCLUSIONS: S. asper was able to extend the lifespan and healthspan of C. elegans which was independent of DAF-16 pathway but dependent on SKN-1 and MAPK which could play a vital role in eliciting the anti-aging, anti-photoaging and neuroprotective effects, as the extract could impart oxidative stress resistance and neuroprotection.

scholarly journals EFFECT OF STREBLUS ASPER LEAVES ON LOCOMOTION, ANXIETY AND COGNITION IN RATS

2019 ◽  
pp. 98-101
Author(s):  
SACHIN NEEKHRA ◽  
HIMANI AWASTHI ◽  
DCP SINGH
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Muscle Relaxant ◽  
Significant Variation ◽  
Control Group ◽  
Hydroalcoholic Extract ◽  
Central Nervous System Disorders ◽  
Inhibition Concentration ◽  
Locomotor Activities ◽  
Streblus Asper

Objective: The current study deals with the evaluation of neuropharmacological activities of hydroalcoholic extract of the plant Streblus asper. Methods: Hydroalcoholic extract of S. asper leaves was administered to animals at the dose of 200 and 400 mg/kg p.o., respectively. The neuropharmacological activities, namely, anxiolytic, muscle-relaxant, nootropic, and locomotor activities of hydroalcoholic extract of S. asper leaves were evaluated. The antioxidant activity of the hydroalcoholic extract of S. asper leaves was also investigated. Results: The dose 400 mg/kg p.o. of hydroalcoholic extract indicated significant variation with control group on neuropharmacological activity, especially nootropic and locomotion, whereas the mentioned dose did not show a significant effect on anxiolytic and muscle-relaxant activities. Percentage scavenging activities and inhibition concentration (IC50) were reported as 63.132 at 100 μg/ml and 35.33, respectively. Conclusion: It was found that hydroalcoholic extract of S. asper leaves can treat central nervous system disorders caused by oxidative stress.

Selective activity of Streblus asper on Mutans streptococci

2000 ◽  
Vol 70 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Suwimol Taweechaisupapong ◽  
Sopit Wongkham ◽  
Supaporn Chareonsuk ◽  
Samran Suparee ◽  
Pennapar Srilalai ◽  
...  
Keyword(s):  
Mutans Streptococci ◽  
Streblus Asper ◽  
Selective Activity

Anti-hepatitis B virus constituents from the stem bark of Streblus asper

2012 ◽  
Vol 82 ◽  
pp. 100-109 ◽  
Author(s):  
Jun Li ◽  
Yan Huang ◽  
Xin-Lan Guan ◽  
Jian Li ◽  
Sheng-Ping Deng ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Stem Bark ◽  
B Virus ◽  
Streblus Asper

scholarly journals Streblus asper Lour. (Shakhotaka): A Review of its Chemical, Pharmacological and Ethnomedicinal Properties

2006 ◽  
Vol 3 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Subha Rastogi ◽  
Dinesh K. Kulshreshtha ◽  
Ajay Kumar Singh Rawat
Keyword(s):  
Cancer Research ◽  
Sri Lanka ◽  
Medicinal Plant ◽  
Biological Evaluation ◽  
The Philippines ◽  
Small Tree ◽  
Tropical Countries ◽  
Streblus Asper

Streblus asperLour is a small tree found in tropical countries, such as India, Sri Lanka, Malaysia, the Philippines and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as filariasis, leprosy, toothache, diarrhea, dysentery and cancer. Research carried out using differentin vitroandin vivotechniques of biological evaluation support most of these claims. This review presents the botany, chemistry, traditional uses and pharmacology of this medicinal plant.

Inhibitory effect of Streblus asper leaf-extract on adhesion of Candida albicans to denture acrylic

2006 ◽  
Vol 106 (3) ◽  
pp. 414-417 ◽  
Author(s):  
S. Taweechaisupapong ◽  
P. Klanrit ◽  
S. Singhara ◽  
W. Pitiphat ◽  
S. Wongkham
Keyword(s):  
Candida Albicans ◽  
Leaf Extract ◽  
Inhibitory Effect ◽  
Streblus Asper
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