Activity-Dependent Plasticity at Associative Memory Cells in the Prefrontal Cortex

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

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Faculty Opinions recommendation of Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1007907.372911 ◽

2006 ◽

Author(s):

Kathleen Rockland

Keyword(s):

Gene Expression ◽

Visual Cortex ◽

Molecular Pathways ◽

Dependent Plasticity ◽

Activity Dependent

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The role of ZIF268/EGR-1 during activity-dependent plasticity of developing visual cortex

Neuroscience Research ◽

10.1016/s0168-0102(98)82462-0 ◽

1998 ◽

Vol 31 ◽

pp. S324

Author(s):

Nobuko Mataga ◽

Brian G. Condie ◽

Sayaka Fujishima ◽

Takao K. Hensch

Keyword(s):

Visual Cortex ◽

Dependent Plasticity ◽

Activity Dependent

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GABA Neurons and Their Role in Activity-Dependent Plasticity of Adult Primate Visual Cortex

Cerebral Cortex - Primary Visual Cortex in Primates ◽

10.1007/978-1-4757-9628-5_3 ◽

1994 ◽

pp. 61-140 ◽

Cited By ~ 16

Author(s):

E. G. Jones ◽

S. H. C. Hendry ◽

J. DeFelipe ◽

D. L. Benson

Keyword(s):

Visual Cortex ◽

Dependent Plasticity ◽

Gaba Neurons ◽

Primate Visual Cortex ◽

Activity Dependent

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P119. Activity-dependent plasticity of the endolymphatic space in vestibular migraine – A single case study

Clinical Neurophysiology ◽

10.1016/j.clinph.2018.04.733 ◽

2018 ◽

Vol 129 (8) ◽

pp. e111

Author(s):

V. Kirsch ◽

S. Becker-Bense ◽

A. Berman ◽

E. Kierig ◽

B. Ertl-Wagner ◽

...

Keyword(s):

Single Case ◽

Vestibular Migraine ◽

Single Case Study ◽

Dependent Plasticity ◽

Activity Dependent ◽

Endolymphatic Space

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Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses

Neuroscience ◽

10.1016/j.neuroscience.2009.01.032 ◽

2009 ◽

Vol 162 (3) ◽

pp. 612-623 ◽

Cited By ~ 29

Author(s):

L.W.J. Bosman ◽

A. Konnerth

Keyword(s):

Purkinje Cell ◽

Climbing Fiber ◽

Dependent Plasticity ◽

Activity Dependent

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Conjunctive representation of what and when in monkey hippocampus and lateral prefrontal cortex during an associative memory task

10.1101/709659 ◽

2019 ◽

Cited By ~ 2

Author(s):

Nathanael A. Cruzado ◽

Zoran Tiganj ◽

Scott L. Brincat ◽

Earl K. Miller ◽

Marc W. Howard

Keyword(s):

Prefrontal Cortex ◽

Associative Memory ◽

Memory Task ◽

Neural Recording ◽

Temporal Coding ◽

Adaptive Memory ◽

Lateral Prefrontal Cortex ◽

The Past ◽

Large Numbers

AbstractAdaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the monkey to associate stimuli separated by about a second in time. After the first stimulus was presented, large numbers of units in both HPC and PFC fired in sequence. Many units fired only when a particular stimulus was presented at a particular time in the past. These results indicate that both HPC and PFC maintain a temporal record of events that could be used to form associations across time. This temporal record of the past is a key component of the temporal coding hypothesis, a hypothesis in psychology that memory not only encodes what happened, but when it happened.

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