A modest increase in 11C-PK11195-PET TSPO binding in depression is not associated with serum C-reactive protein or body mass index

ABSTRACTBACKGROUNDImmune mechanisms have been implicated in the pathogenesis of depression, and translocator-protein (TSPO) targeted positron emission tomography (PET) has been used to assess neuroinflammation in major depressive disorder. We aimed to: (i) test the prior hypothesis of significant case-control differences in TSPO binding in anterior cingulate (ACC), prefrontal (PFC) and insular (INS) cortical regions; and (ii) explore the relationship between cerebral TSPO binding and peripheral blood concentration of C-reactive protein (CRP).METHODS51 depressed cases with Hamilton Depression Rating Scale score > 13 (median 17; IQR 16-22) and 25 healthy matched controls underwent dynamic brain 11C-PK11195 PET and peripheral blood immune marker characterisation. Depressed cases were divided into high CRP (>3mg/L;N=20) and low CRP (<3mg/L;N=31).RESULTSAcross the three regions, TSPO binding was significantly increased in cases vs controls (; F(1,71)=6.97, P=0.01). which was not influenced by differences in body mass index (BMI). The case-control difference was greatest in ACC (d=0.49; t(74)=2.00, .P=0.03) and not significant in PFC or INS (d=0.27; d=0.36). Following CRP stratification, significantly higher TSPO binding was observed in low CRP depression compared to controls (d=0.53; t(54)=1.96, P=0.03). These effect sizes are comparable to prior MDD case-control TSPO PET data. No significant correlations were observed between TSPO and CRP measures.CONCLUSIONSConsistent with previous findings, there is a modest increase in TSPO binding in depressed cases compared to healthy controls. The lack of a significant correlation between brain TSPO binding and blood CRP concentration or BMI poses questions about the interactions between central and peripheral immune responses in the pathogenesis of depression.

Download Full-text

Faculty Opinions recommendation of Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3580971.3288073 ◽

2010 ◽

Author(s):

Ingrid Meulenbelt ◽

Steffan Daniel Bos

Keyword(s):

Body Mass Index ◽

Genetic Variation ◽

Body Mass ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

Download Full-text

The relation between high-sensitivity C-reactive protein and maximum body mass index in patients with psoriasis

British Journal of Dermatology ◽

10.1111/j.1365-2133.2008.08467.x ◽

2008 ◽

Vol 158 (5) ◽

pp. 1141-1143 ◽

Cited By ~ 15

Author(s):

T. Ohtsuka

Keyword(s):

Body Mass Index ◽

Body Mass ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Maximum Body

Download Full-text

Combined body mass index with high-sensitivity C-reactive protein as independent predictors for chronic kidney disease in a relatively healthy population in Taiwan

European Journal of Clinical Nutrition ◽

10.1038/ejcn.2016.28 ◽

2016 ◽

Vol 70 (7) ◽

pp. 766-771 ◽

Cited By ~ 1

Author(s):

Y-W Tsai ◽

M-C Lu ◽

Y-H Lin ◽

Y-C Lee ◽

W-C Li ◽

...

Keyword(s):

Body Mass Index ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Body Mass ◽

High Sensitivity ◽

Healthy Population ◽

C Reactive Protein ◽

Reactive Protein

Download Full-text

Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000074565.79230.ab ◽

2003 ◽

Vol 35 (7) ◽

pp. 1160-1166 ◽

Cited By ~ 85

Author(s):

ERIC S. RAWSON ◽

PATTY S. FREEDSON ◽

STAVROULA K. OSGANIAN ◽

CHARLES E. MATTHEWS ◽

GEORGE REED ◽

...

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Body Mass ◽

C Reactive Protein ◽

Reactive Protein

Download Full-text

Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

Annals of the Rheumatic Diseases ◽

10.1136/ard.2009.125260 ◽

2010 ◽

Vol 69 (11) ◽

pp. 1976-1982 ◽

Cited By ~ 46

Author(s):

Hanneke J M Kerkhof ◽

Sita M A Bierma-Zeinstra ◽

Martha C Castano-Betancourt ◽

Moniek P de Maat ◽

Albert Hofman ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Genetic Variation ◽

Body Mass ◽

Analysis Of Covariance ◽

C Reactive Protein ◽

Knee Oa ◽

Reactive Protein ◽

Serum Crp ◽

The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

Download Full-text

C-reactive Protein, Body Mass Index, and Diabetic Retinopathy

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.09-4939 ◽

2010 ◽

Vol 51 (9) ◽

pp. 4458 ◽

Cited By ~ 49

Author(s):

Laurence Shen Lim ◽

E. Shyong Tai ◽

Paul Mitchell ◽

Jie Jin Wang ◽

Wan Ting Tay ◽

...

Keyword(s):

Body Mass Index ◽

Diabetic Retinopathy ◽

Body Mass ◽

Protein Body ◽

C Reactive Protein ◽

Reactive Protein

Download Full-text

The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2010-1733 ◽

2011 ◽

Vol 96 (1) ◽

pp. E225-E232 ◽

Cited By ~ 46

Author(s):

Andrea M. Haqq ◽

Michael J. Muehlbauer ◽

Christopher B. Newgard ◽

Steven Grambow ◽

Michael Freemark

Keyword(s):

Body Mass Index ◽

Insulin Sensitivity ◽

Body Mass ◽

Density Lipoprotein ◽

High Sensitivity ◽

Metabolic Phenotype ◽

Prader Willi Syndrome ◽

C Reactive Protein ◽

Reactive Protein ◽

Total Adiponectin

Context: Insulin sensitivity is higher in patients with Prader-Willi syndrome (PWS) than in body mass index-matched obese controls (OCs). Factors contributing to the heightened insulin sensitivity of PWS remain obscure. We compared the fasting levels of various hormones, cytokines, lipids, and liver function tests in 14 PWS patients and 14 OCs with those in 14 age- and gender-matched lean children (LC). We hypothesized that metabolic profiles of children with PWS are comparable with those of LC, but different from those of OCs. Results: Leptin levels were comparable in PWS patients and OCs, suggesting comparable degrees of adiposity. Glucose levels were comparable among groups. However, fasting insulin concentrations and homeostasis model assessment insulin resistance index were lower in PWS patients than in OCs (P < 0.05) and similar to LC. Moreover, high-density lipoprotein levels were lower and triglycerides higher in OCs (P < 0.05) but not PWS patients. Total adiponectin, high-molecular-weight (HMW) adiponectin and the HMW to total adiponectin ratio were higher in PWS patients (P < 0.05) than in OCs and similar to LC. High-sensitivity C-reactive protein and IL-6 levels were higher in OCs than in PWS patients or LC (P < 0.05). Nevertheless, PAI-1 levels were elevated in both OC and PWS patients. There were no group differences in glucagon-like peptide-1, macrophage chemoattractant protein-1, TNFα, IL-2, IL-8, IL-10, IL-12p40, IL-18, resistin, total or low-density lipoprotein cholesterol, aspartate aminotransferase, or alanine aminotransferase. Conclusions: The heightened insulin sensitivity of PWS patients relative to OCs is associated with higher levels of adiponectin and lower levels of high-sensitivity C-reactive protein and IL-6. Future studies will determine whether PWS children are protected from obesity comorbidities such as type 2 diabetes, hyperlipidemia, and nonalcoholic fatty liver disease.

Download Full-text