Venous Pulse Wave Velocity variation in response to a simulated fluid challenge in healthy subjects

2021 ◽  
Vol 63 ◽  
pp. 102177
Author(s):  
Leonardo Ermini ◽  
Nadia Elvira Chiarello ◽  
Carlo De Benedictis ◽  
Carlo Ferraresi ◽  
Silvestro Roatta
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Healthy Subjects ◽  
Pulse Wave ◽  
Fluid Challenge ◽  
Velocity Variation ◽  
Venous Pulse

scholarly journals Effects of an Innovative Head-Up Tilt Protocol on Blood Pressure and Arterial Stiffness Changes

2021 ◽  
Vol 10 (6) ◽  
pp. 1198
Author(s):  
Victor N. Dorogovtsev ◽  
Dmitry S. Yankevich ◽  
Nandu Goswami
Keyword(s):  
Blood Pressure ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Healthy Subjects ◽  
Pulse Wave ◽  
Task Force ◽  
Column Height ◽  
Tilt Test ◽  
Test Protocol ◽  
Head Up Tilt

The objective of our study was to identify blood pressure (BP) and pulse wave velocity (PWV) changes during orthostatic loading, using a new the head-up tilt test (HUTT), which incorporates the usage of a standardized hydrostatic column height. Methods: 40 healthy subjects 20–32 years performed HUTT, which was standardized to a height of the hydrostatic column at 133 cm. Exposure time was 10 min in each of 3 positions: horizontal supine 1, HUTT, and horizontal supine 2. The individual tilt up angle made it possible to set the standard value of the hydrostatic column. Hemodynamic parameters were recorded beat to beat using “Task Force Monitor 3040 i”, pulse-wave velocity (PWV) was measured with a sphygmograph–sphygmomanometer VaSera VS1500N. Results: Orthostatic loading caused a significant increase in heart rate (HR) and a decrease in stroke volume (SV) (p < 0.05) but no significant reductions in cardiac output, changes in total vascular resistance (TVR), or BP. An analysis of personalized data on systolic blood pressure (SBP) changes in tilt up position as compared to horizontal position (ΔSBP) revealed non-significant changes in this index in 48% of subjects (orthostatic normotension group), in 32% there was a significant decrease in it (orthostatic hypotension group) and in 20% there was a significant increase in it (orthostatic hypertension group). These orthostatic changes were not accompanied by any clinical symptoms and/or syncope. During HUTT, all subjects had in the PWV a significant increase of approximately 27% (p < 0.001). Conclusion: The new test protocol involving HUTT standardized to a height of hydrostatic column at 133 cm causes typical hemodynamics responses during orthostatic loading. Individual analysis of the subjects revealed subclinical orthostatic disorders (OSD) in up to 52% of the test persons. During HUTT, all test subjects showed a significant increase in PWV. The new innovative HUTT protocol can be applied in multi-center studies in healthy subjects to detect preclinical forms of orthostatic disorders under standard gravity load conditions.

scholarly journals Hyperemia-Related Changes in Arterial Stiffness: Comparison between Pulse Wave Velocity and Stiffness Index in the Vascular Reactivity Assessment

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Juan Torrado ◽  
Daniel Bia ◽  
Yanina Zócalo ◽  
Ignacio Farro ◽  
Federico Farro ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Healthy Subjects ◽  
Vascular Reactivity ◽  
Pulse Wave ◽  
Stiffness Index ◽  
Experimental Session ◽  
Temporal Course ◽  
Peripheral Pulse

Carotid-to-radial pulse wave velocity (PWVcr) has been proposed to evaluate endothelial function. However, the measurement ofPWVcris not without limitations. A new simple approach could have wide application.Stiffness index(SI) is obtained by analysis of the peripheral pulse wave and gives reproducible information about stiffness of large arteries. This study assessed the effects of hyperemia on SI and compared it withPWVcrin 14 healthy subjects. Both were measured at rest and during 8 minutes after ischemia. SI temporal course was determined. At 1 minute, SI andPWVcrdecreased (5.58±0.24to5.34±0.23 m/s,P<0.05;7.8±1.0to7.2±0.9 m/s;P<0.05, resp.). SI was positively related toPWVcrin baseline (r=0.62,P<0.05), at 1 minute (r=0.79,P<0.05), and during the whole experimental session (r=0.52,P<0.05).Conclusion. Hyperemia significantly decreases SI in healthy subjects. SI was related toPWVcrand could be used to facilitate the evaluation of hyperemia-related changes in arterial stiffness.

scholarly journals ABCA1-dependent serum cholesterol efflux capacity inversely correlates with pulse wave velocity in healthy subjects

2012 ◽  
Vol 54 (1) ◽  
pp. 238-243 ◽  
Author(s):  
Elda Favari ◽  
Nicoletta Ronda ◽  
Maria Pia Adorni ◽  
Francesca Zimetti ◽  
Paolo Salvi ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Serum Cholesterol ◽  
Healthy Subjects ◽  
Cholesterol Efflux ◽  
Pulse Wave ◽  
Cholesterol Efflux Capacity

P3573Different contribution of sympathetic nerve activity to pulse wave velocity and arterial velocity pulse index in healthy subjects

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Sugimoto ◽  
H Murai ◽  
T Hamaoka ◽  
Y Mukai ◽  
O Inoue ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Sympathetic Nerve ◽  
Healthy Subjects ◽  
Sympathetic Nerve Activity ◽  
Pulse Wave ◽  
Velocity Pulse ◽  
Nerve Activity ◽  
Reflected Wave ◽  
The Relationship

Abstract Background Pulse Wave Velocity (PWV) is associated with the net effect of arterial stiffness and sympathetic nerve activity. Recent study demonstrated the significant relationship between PWV and muscle sympathetic nerve activity (MSNA). Arterial Velocity pulse Index (AVI) is a newly developed parameter, which could evaluate vascular reflected wave, regardless of aortic form. Vascular reflected wave is considered to be associated with sympathetic nerve activity, however little is known about the relationship between AVI and MSNA. Purpose The purpose of this study was to evaluate the relationship between AVI or PWV and MSNA in healthy subject. Method 21 healthy subjects were included in this study. AVI was measured by NAS-1000 (Nihon Koden, Japan), calculated from the time series of occlusive cuff pressure in the left upper arm. Brachial-ankle PWV (baPWV) was measured by BP-203RPEIII (Omron Healthcare, Japan). MSNA was recorded from left peroneal nerve by microneurography using tungsten microelectrode. All measurements were performed in the same day morning. Results The mean age was 31+5 years and body mass index (BMI) 22.5+3.0 kg/m2. In regression analysis, baPWV was significantly associated with age (r=0.64 P<0.05) but not with MSNA or BMI. AVI was significantly associated with MSNA (r=0.73, P<0.05) but not with age and BMI. Conclusion We found that different contribution of MSNA to baPWV and AVI and revealed that AVI was associated with MSNA in healthy subjects. These results suggest that AVI could reflect sympathetic nerve activity compared to baPWV.

Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human

2012 ◽  
Vol 113 (5) ◽  
pp. 727-735 ◽  
Author(s):  
Alessandra Borlotti ◽  
Ashraf W. Khir ◽  
Ernst R. Rietzschel ◽  
Marc L. De Buyzere ◽  
Sebastian Vermeersch ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Femoral Artery ◽  
Healthy Subjects ◽  
Pulse Wave ◽  
Wave Intensity ◽  
Age And Gender ◽  
Femoral Arteries ◽  
And Gender

We recently introduced noninvasive methods to assess local pulse wave velocity (PWV) and wave intensity (ndI) in arteries based on measurements of flow velocity (U) and diameter (D). Although the methods were validated in an experimental setting, clinical application remains lacking. The aim of this study was therefore to investigate the effect of age and gender on PWV and ndI in the carotid and femoral arteries of an existing population. We measured D and U in the carotid and femoral arteries of 1,774 healthy subjects aged 35-55 yr, a subgroup of the Asklepios population. With the use of the lnDU-loop method, we calculated local PWV, which was used to determine arterial distensibility (nDs). We then used the new algorithm to determine maximum forward and backward wave intensities (ndI+max and ndI−min, respectively) and the reflection index (nRI). On average, PWV was higher, and nDs was lower in the femoral than at the carotid arteries. At the carotid artery, PWV increased with age, but nDs, ndI+max, and ndI−min decreased; nRI did not change with age. At the femoral artery, PWV was higher, and nDs was lower in male, but all parameters did not change significantly with age in both women and men. We conclude that the carotid artery is more affected by the aging process than the femoral artery, even in healthy subjects. The new techniques provide mechanical and hemodynamic parameters, requiring only D and U measurements, both of which can be acquired using ultrasound equipment widely available today, hence their advantage for potential use in the clinical setting.

scholarly journals Cross-Sectional Relationship between Carotid-Femoral Pulse Wave Velocity and Biomarkers in Vascular-Related Diseases

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jinbo Liu ◽  
Kuanting Wang ◽  
Huan Liu ◽  
Hongwei Zhao ◽  
Wei Huang ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Healthy Subjects ◽  
Pulse Wave ◽  
Cross Sectional ◽  
Entire Study ◽  
Urine Albumin ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objectives. The present study was done to investigate the relationship between carotid-femoral pulse wave velocity (CFPWV) and biomarkers such as homocysteine (Hcy), N-terminal pro-brain natriuretic peptide (NT-proBNP), and urine albumin (microalbumin) (UAE) in vascular-related diseases. Methods. 656 subjects were enrolled into our study. There were 377 patients with hypertension, 231 with coronary heart disease, 154 with diabetes mellitus, and 186 healthy subjects. They were divided into four groups according to the number of suffered diseases: group 1 had only one of three diseases, group 2 had two, and group 3 had all of three diseases. CFPWV was measured by Complior apparatus. Results. CFPWV was significantly higher in group 3 than in the healthy group, group 1, and group 2 (12.71 ± 2.38 vs 10.11 ± 2.28, 10.70 ± 2.12, and 11.92 ± 2.55, all p<0.05). The level of Hcy was significantly higher in group1, group 2, and group 3 than in healthy subjects, respectively. Levels of Log NT-proBNP and Log UAE were significantly higher in group 3 than in group 1 (2.27 ± 0.4 vs 2.10 ± 0.4, 1.00 ± 0.65 vs 0.68 ± 0.56, both p<0.05). Positive correlation between CFWV and Hcy, Log UAE, and Log NT-proBNP was found in the entire study group (r = 0.109, 0.196, and 0.119, all p<0.05). Multivariate analysis showed that pulse pressure, age, fasting plasma glucose, diastolic blood pressure, body mass index, and Log UAE were independent associating factors of CFPWV in all subjects (β = 0.334, p<0.001; β = 0.333, p<0.001; β = 0.126, p=0.004; β = 0.137, p=0.003; β = −0.142, p=0.002; and β = 0.098, p=0.031). Conclusions. CFPWV was significantly higher in subjects with hypertension, CHD, and DM. There was correlation between CFPWV and biomarkers such as NT-proBNP, Hcy, and urine albumin (microalbumin).

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