The association between smokeless tobacco use and pancreatic adenocarcinoma: A systematic review

ObjectiveSmokeless tobacco use is a public health issue throughout the world, but reviews and analyses of circulatory disease risks associated with smokeless tobacco use may be outdated or incomplete. This study provides a thorough and comprehensive review and meta-analysis of circulatory disease risks in high-income countries, including recently published study estimates.MethodsWe conducted a systematic review of studies of circulatory disease risks associated with smokeless tobacco use in Europe and North America that were identified from electronic databases and reference lists. Study estimates were extracted by region, smokeless tobacco use status, cigarette smoking status, and circulatory condition and combined in meta-analysis using a random-effects model. We used the Newcastle-Ottawa scale to assess study quality and risk of bias.ResultsWe identified 17 relevant cohort studies, two pooled analyses, five case–control studies and one cross-sectional analysis. We found increased risk of heart disease (relative risk (RR) 1.17, 95% CI 1.09 to 1.27) and stroke (RR 1.28, 95% CI 1.01 to 1.62) among US smokeless tobacco users compared with non-users. Increased circulatory disease risk was not observed among Swedish smokeless tobacco users.ConclusionUS smokeless tobacco users were found to have increased risk of heart disease and stroke.

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Smokeless Tobacco Use in the United States Military: A Systematic Review

PsycEXTRA Dataset ◽

10.1037/e663312011-001 ◽

2011 ◽

Author(s):

Hannah E. Bergman ◽

Yvonne M. Hunt ◽

Gary R. Roberson ◽

Sarah E. Evans

Keyword(s):

United States ◽

Systematic Review ◽

Tobacco Use ◽

Smokeless Tobacco ◽

The United States ◽

United States Military ◽

Smokeless Tobacco Use

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A systematic review of epidemiological studies on the association between smokeless tobacco use and coronary heart disease

Journal of Public Health and Epidemiology ◽

10.5897/jphe11.175 ◽

2011 ◽

Vol 3 (12) ◽

Author(s):

Muhammad Aziz Rahman

Keyword(s):

Systematic Review ◽

Coronary Heart Disease ◽

Heart Disease ◽

Tobacco Use ◽

Smokeless Tobacco ◽

Epidemiological Studies ◽

Smokeless Tobacco Use

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Association between Smokeless Tobacco Use and Risk of Periodontitis in Asian Countries: A Systematic Review and Meta-Analysis

Asian Pacific Journal of Cancer Prevention ◽

10.31557/apjcp.2021.22.10.3061 ◽

2021 ◽

Vol 22 (10) ◽

pp. 3061-3074

Author(s):

Abhishek Mehta ◽

Venkitachalam Ramanarayanan ◽

Vineetha Karuveettil ◽

Chandrashekar Janakiram

Keyword(s):

Systematic Review ◽

Tobacco Use ◽

Smokeless Tobacco ◽

Meta Analysis ◽

Asian Countries ◽

Smokeless Tobacco Use

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Smokeless tobacco use and reproductive outcomes among women: a systematic review

F1000Research ◽

10.12688/f1000research.73944.1 ◽

2021 ◽

Vol 10 ◽

pp. 1171

Author(s):

A.G. Radhika ◽

Sutapa B. Neogi ◽

Preetha GS ◽

Sumant Swain ◽

Jaswinder Kaur ◽

...

Keyword(s):

Systematic Review ◽

Tobacco Use ◽

Smokeless Tobacco ◽

Research Question ◽

Reproductive Outcomes ◽

Menstrual Disorders ◽

Cross Sectional ◽

Urinary Cotinine ◽

Organ Systems ◽

Smokeless Tobacco Use

Background: Both smoked and smokeless tobacco use have deleterious effects on most major organ systems including the reproductive system. We conducted a systematic review on smokeless tobacco (SLT) use and reproductive outcomes among women. Methods: We searched Pubmed, ProQuest, Cochrane, Wiley and Emerald databases for studies involving smokeless tobacco use in women with any or a combination of three conditions: infertility, menstrual disorders and pelvic inflammatory disease (PID). Eligibility criteria included English language publications from 1st January 1990 - 31st October 2020. CADIMA software used for filtering the studies and modified SIGN checklist for the quality assessment. The findings are reported as per the PRISMA guidelines. The AXIS and ROBIN E tool were used for assessment of risk of bias. Results: In total, three studies addressed our research question. Two studies addressed infertility (prospective cohort: n=501, cross sectional: n=192) of which, the cross-sectional study compared the mean cotinine levels between those with infertility, menstrual disorders and PID. This study also explored the association between SLT and PID. PID was the most common gynecological complaint. Women with PID had significantly higher urinary cotinine levels = 24.95±12.259) ng/ ml (p=0.0144). Mean urinary cotinine in women with menstrual complaints was 19.32±10.29 ng/ml. The other study used population-based sampling of 501 couples who attempted pregnancy (enrolled in the LIFE Study). Results showed that only 2% (n=28) of men and none of the women used smokeless tobacco. Compared with never users of tobacco, smoking by females was individually associated with longer time-to-pregnancy; smoking among males remained significant when modeling partners together. Conclusions: Available studies exploring associations between SLT and reproductive outcomes are inconclusive due to limitations in the study methodologies. More studies with robust study designs are required from low- and middle-income countries with high prevalence of SLT use.

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