Naswar (Smokeless Tobacco) Use and the Risk of Oral Cancer in Pakistan: A Systematic Review With Meta-Analysis

2017 ◽  
Vol 21 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Zohaib Khan ◽  
Rizwan Abdulkader Suliankatchi ◽  
Thomas L Heise ◽  
Steffen Dreger
Open Heart ◽  
2018 ◽  
Vol 5 (2) ◽  
pp. e000846 ◽  
Author(s):  
Brian L Rostron ◽  
Joanne T Chang ◽  
Gabriella M Anic ◽  
Manju Tanwar ◽  
Cindy M Chang ◽  
...  

ObjectiveSmokeless tobacco use is a public health issue throughout the world, but reviews and analyses of circulatory disease risks associated with smokeless tobacco use may be outdated or incomplete. This study provides a thorough and comprehensive review and meta-analysis of circulatory disease risks in high-income countries, including recently published study estimates.MethodsWe conducted a systematic review of studies of circulatory disease risks associated with smokeless tobacco use in Europe and North America that were identified from electronic databases and reference lists. Study estimates were extracted by region, smokeless tobacco use status, cigarette smoking status, and circulatory condition and combined in meta-analysis using a random-effects model. We used the Newcastle-Ottawa scale to assess study quality and risk of bias.ResultsWe identified 17 relevant cohort studies, two pooled analyses, five case–control studies and one cross-sectional analysis. We found increased risk of heart disease (relative risk (RR) 1.17, 95% CI 1.09 to 1.27) and stroke (RR 1.28, 95% CI 1.01 to 1.62) among US smokeless tobacco users compared with non-users. Increased circulatory disease risk was not observed among Swedish smokeless tobacco users.ConclusionUS smokeless tobacco users were found to have increased risk of heart disease and stroke.


2021 ◽  
Vol 22 (10) ◽  
pp. 3061-3074
Author(s):  
Abhishek Mehta ◽  
Venkitachalam Ramanarayanan ◽  
Vineetha Karuveettil ◽  
Chandrashekar Janakiram

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e037819
Author(s):  
Ediane De Queiroz Andrade ◽  
Carla Rebeca Da Silva Sena ◽  
Adam Collison ◽  
Vanessa E Murphy ◽  
Gillian Sandra Gould ◽  
...  

ObjectiveTo evaluate what is known about active tobacco use during pregnancy and the association with infant respiratory health.DesignSystematic review and meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesMEDLINE, EMBASE, Cochrane, CINAHL, and Maternity and Infant Care were searched thoroughly until June 2020.Eligibility criteria for selecting studiesWe included case–control and cohort studies estimating the association between active tobacco use during pregnancy and infant respiratory health (wheezing and apnoea) and lung function parameters in the first 12 months of life.Data extraction and synthesisExtraction and risk of bias assessment were conducted by two independent reviewers. The odds ratio, relative risk and mean differences were pooled with a 95% CI using the generic inverse variance method. Heterogeneity was assessed and expressed by percentage using I2.ResultsWe identified 4423 abstracts, and 21 publications met the eligibility criteria. Pooled OR showed an increase in wheezing episodes in infants born to mothers who were active tobacco users during pregnancy (OR 1.50, 95% CI 1.27 to 1.77, p<0.01). Mixed results were found on lung function parameters, and a meta-analysis including two studies with comparable methodology showed a trend towards reduced maximum flow rate at functional residual capacity of −34.59 mL/s (95% CI −72.81 to 3.63, p=0.08) in 1-month-old infants born to women who smoked during pregnancy. A higher risk of apnoea was described for infants born to mothers who used smokeless tobacco during pregnancy, while the results in infants born to women who actively smoked tobacco during pregnancy were non-conclusive.ConclusionInfants born to mothers who actively smoked during pregnancy are at higher odds of having wheeze and may have lower lung function. Smokeless tobacco use in pregnancy may increase the risk of apnoea in infancy.PROSPERO registration numberCRD42018083936.


2014 ◽  
Vol 38 (6) ◽  
pp. 647-653 ◽  
Author(s):  
Matthew D. Burkey ◽  
Shari Feirman ◽  
Han Wang ◽  
Samuel Ravi Choudhury ◽  
Surbhi Grover ◽  
...  

1994 ◽  
Vol 30 (5) ◽  
pp. 365-366 ◽  
Author(s):  
P.C. Gupta ◽  
R. Sankaranarayanan ◽  
H. Vainio

1997 ◽  
Vol 11 (3) ◽  
pp. 313-321 ◽  
Author(s):  
D.M. Winn

Persons who use chewing tobacco and snuff experience an increased risk of oral cancer. Because of the pharmacologic properties of nicotine and other constituents of smokeless tobacco, there is also concern that smokeless tobacco products may lead to cardiovascular diseases as well. The relatively few human population studies to date conflict with respect to whether smokeless tobacco use elevates cardiovascular risk factors or leads to cardiovascular disease or death from cardiovascular causes. Hemoglobin adducts to carcinogens present in smokeless tobacco products are measurable in the blood of smokeless tobacco users, indicating that smokeless-tobacco-related carcinogens circulate throughout the body. This prompts a concern that smokeless tobacco may increase risks of other cancers as well. The evidence to date from epidemiologic studies indicates no relationship between smokeless tobacco and bladder cancer, but there is suggestive evidence linking smokeless tobacco use to prostate cancer risk. Only single studies have been conducted of some cancers, and inconsistencies among studies of the same cancer site have been reported. Molecular epidemiologic studies may help identify markers of malignant transformation in smokeless tobacco users that may help in early intervention to prevent or ameliorate the consequences of oral cancer. Further studies are needed to determine more clearly the cardiovascular and non-oral cancer risks potentially associated with smokeless tobacco use.


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