Acute- or Subacute-Onset Lung Complications in Treating Patients with Rheumatoid Arthritis

2013 ◽  
Vol 64 (3) ◽  
pp. 200-207 ◽  
Author(s):  
Reiko Nakajima ◽  
Fumikazu Sakai ◽  
Toshihide Mimura ◽  
Hitoshi Tokuda ◽  
Masahiro Takahashi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
Interstitial Pneumonia ◽  
Inflammatory Arthritis ◽  
Systemic Disease ◽  
Airway Disease ◽  
Drug Induced ◽  
Pleural Diseases ◽  
Rheumatoid Nodules ◽  
Pictorial Review

Rheumatoid arthritis (RA) is a common systemic disease that manifests as inflammatory arthritis of multiple joints and produces a wide variety of intrathoracic lesions, including pleural diseases, diffuse interstitial pneumonia, rheumatoid nodules, and airway disease. Patients treated for RA can have associated lung disease that commonly manifests as diffuse interstitial pneumonia, drug-induced lung injury, and infection. The purpose of this pictorial review is to illustrate the radiographic and clinical features of lung complications of acute or subacute onset in patients treated for RA and to show the computed tomography features of these complications.

Rheumatoid nodules of the larynx

1998 ◽  
Vol 112 (6) ◽  
pp. 573-574 ◽  
Author(s):  
Waldemar Trolle Sørensen ◽  
Kim Møller-Andersen ◽  
Nille Behrendt
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
Ct Scan ◽  
Direct Laryngoscopy ◽  
Thyroid Cartilage ◽  
Large Tumour ◽  
Upper Airways ◽  
Rheumatoid Nodules

AbstractA 67-year-old woman with rheumatoid arthritis was hospitalized because of dysphagia and severe nodulosis. Over a two-year period the patient had been treated with methotrexate. A computed tomography (CT) scan of the neck showed a 2 × 2 cm large tumour behind the top left lateral thyroid cartilage. A biopsy taken during direct laryngoscopy showed it was a rheumatic nodule. Treatment with colchicine reduced the patient's dysphagia. As methotrexate is used increasingly in the treatment of rheumatoid arthritis and as this particular drug causes rheumatic nodules in five to 10 per cent of the patients, it must be foreseen that the incidence of nodules in the upper airways will increase.

Benign Rheumatoid Nodules

PEDIATRICS ◽  
1975 ◽  
Vol 56 (1) ◽  
pp. 29-33
Author(s):  
F. Estelle ◽  
R. Simons ◽  
Jane G. Schaller
Keyword(s):  
Rheumatoid Arthritis ◽  
Antinuclear Antibodies ◽  
Systemic Disease ◽  
Skin Grafting ◽  
Surgical Excision ◽  
Rheumatoid Factors ◽  
Adult Onset ◽  
Rheumatoid Nodules ◽  
Large Size ◽  
Asymptomatic Children

Fifteen asymptomatic children with benign rheumatoid nodules, followed up to 12 years, are described. Nodules are characterized by subcutaneous location with predilection for pretibial regions and scalp, occasional large size, spontaneous regression, and frequent recurrence. Granuloma annulare was present in two patients. All 15 children were healthy and free from rheumatoid arthritis, rheumatic fever, or any other recognizable systemic disease at followup and none had positive tests for antinuclear antibodies or rheumatoid factors. Histologically the nodules closely resembled those seen in adult-onset rheumatoid arthritis. Though biopsy may be useful for confirmation of the clinical diagnosis of benign rheumatoid nodules, wide surgical excision, skin grafting, and treatment with medication are unnecessary in this selflimited syndrome.

scholarly journals Pulmonary rheumatoid nodules leading to spontaneous pneumothorax

2012 ◽  
Vol 6 (4) ◽  
pp. 57-60
Author(s):  
KR Dewan ◽  
SK Nanda ◽  
RS Twayana
Keyword(s):  
Rheumatoid Arthritis ◽  
Spontaneous Pneumothorax ◽  
Metastatic Cancer ◽  
Airway Disease ◽  
Methotrexate Therapy ◽  
Chronic Obstructive ◽  
Chronic Obstructive Airway Disease ◽  
Medical Sciences ◽  
Rheumatoid Nodules ◽  
Long Time

Several pulmonary diseases are associated with spontaneous pneumothorax, including bronchial asthma, chronic obstructive airway disease, bronchiectasis, pneumonia, abscess, primary or metastatic cancer, and chronic interstitial lung disease.1 Spontaneous pneumothorax secondary to rheumatoid nodules which is one of the extra-articular manifestations of rheumatoid arthritis is rare but occasionally described.2There are some reports resulting in spontaneous pneumothorax especially on patients on methotrexate or leflunomide treatment.3We describe a case of rheumatoid arthritis who was on methotrexate therapy from a long time complicating in right sided spontaneous pneumothorax. Journal of College of Medical Sciences-Nepal,2011,Vol-6,No-4, 57-60 DOI: http://dx.doi.org/10.3126/jcmsn.v6i4.6729

Computed tomography of pulmonary changes in rheumatoid arthritis: carcinoembryonic antigen (CEA) as a marker of airway disease

2016 ◽  
Vol 36 (4) ◽  
pp. 531-539 ◽  
Author(s):  
Milene Caroline Koch ◽  
Ivânio Alves Pereira ◽  
Luiz Felipe Souza Nobre ◽  
Fabricio Souza Neves
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
Carcinoembryonic Antigen ◽  
Airway Disease ◽  
Pulmonary Changes

High 11[beta]-HSD1 activity is associated with progression to rheumatoid arthritis in patients first presenting with inflammatory arthritis

2014 ◽  
Author(s):  
Dominika Nanus ◽  
Andrew D Filer ◽  
Lorraine Yeo ◽  
Dagmar Scheel-Toellner ◽  
Rowan Hardy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Arthritis

Rheumatoid Arthritis: History, Stages, Epidemiology, Pathogenesis, Diagnosis and Treatment

2017 ◽  
Vol 9 (02) ◽  
Author(s):  
Abeer Fauzi Al-Rubaye ◽  
Mohanad Jawad Kadhim ◽  
Imad Hadi Hameed
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Systemic Disease ◽  
Modern Medicine ◽  
Whole Body ◽  
Internal Organs ◽  
Synthetic Drugs ◽  
Relieve Pain ◽  
Medicinal Treatment ◽  
Natural Drugs

The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs. Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and internal organs such as lungs, heart and eyes. Although numbers of synthetic drugs are being used as standard treatment for rheumatoid arthritis but they have adverse effect that can compromise the therapeutic treatment. Unfortunately, there is still no effective known medicinal treatment that cures rheumatoid arthritis as the modern medicine can only treat the symptoms of this disease that means to relieve pain and inflammation of joints. It is possible to use the herbs and plants in various forms in order to relieve the pain and inflammation in the joints. There are so many medicinal plants that have shown anti rheumatoid arthritis properties. So the plants and plant product with significant advantages are used for the treatment of rheumatoid arthritis. The present review is focused on the medicinal plants having anti rheumatoid arthritis activity

Evaluation of Serum Calprotectin Level and Disease Activity in Patients with Rheumatoid Arthritis

2019 ◽  
Vol 15 (4) ◽  
pp. 316-320
Author(s):  
Mir Amir Aghdashi ◽  
Seyedmostafa Seyedmardani ◽  
Sholeh Ghasemi ◽  
Zohre Khodamoradi
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Inflammatory Arthritis ◽  
Unknown Etiology ◽  
Tender Joint Count ◽  
Serum Samples ◽  
Tender Joint ◽  
Cross Sectional ◽  
Calprotectin Level ◽  
Remission Phase

Background: Rheumatoid Arthritis (RA) is the most common type of chronic inflammatory arthritis with unknown etiology marked by a symmetric, peripheral polyarthritis. Calprotectin also can be used as a biomarker of disease activity in inflammatory arthritis and other autoimmune diseases. Objective: In this study, we evaluated the association between serum calprotectin level and severity of RA activity. Methods: A cross-sectional study was conducted on 44 RA patients with disease flare-up. Serum samples were obtained from all patients to measure calprotectin, ESR, CRP prior to starting the treatment and after treatment period in the remission phase. Based on Disease Activity Score 28 (DAS28), disease activity was calculated. Results: Of 44 RA patients, 9(20.5%) were male and 35(79.5%) were female. The mean age of our cases was 53±1.6 years. Seventeen (38.6%) patients had moderate DAS28 and 27(61.4%) had high DAS28. The average level of calprotectin in the flare-up phase was 347.12±203.60 ng/ml and 188.04±23.58 ng/ml in the remission phase. We did not find any significant association between calprotectin and tender joint count (TJC; P=0.22), swollen joint count (SJC; P=0.87), and general health (GH; P=0.59), whereas significant associations were found between the calprotectin level and ESR (p=0.001) and DAS28 (p=0.02). The average calprotectin level in moderate DAS28 (275.21±217.96 ng/ml) was significantly lower than that in high DAS28 (392.4±183.88 ng/ml) (p=0.05). Conclusion: We showed that the serum level of calprotectin can be a useful and reliable biomarker in RA activity and its severity. It also can predict treatment response.

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