Benign Rheumatoid Nodules

PEDIATRICS ◽  
1975 ◽  
Vol 56 (1) ◽  
pp. 29-33
Author(s):  
F. Estelle ◽  
R. Simons ◽  
Jane G. Schaller
Keyword(s):  
Rheumatoid Arthritis ◽  
Antinuclear Antibodies ◽  
Systemic Disease ◽  
Skin Grafting ◽  
Surgical Excision ◽  
Rheumatoid Factors ◽  
Adult Onset ◽  
Rheumatoid Nodules ◽  
Large Size ◽  
Asymptomatic Children

Fifteen asymptomatic children with benign rheumatoid nodules, followed up to 12 years, are described. Nodules are characterized by subcutaneous location with predilection for pretibial regions and scalp, occasional large size, spontaneous regression, and frequent recurrence. Granuloma annulare was present in two patients. All 15 children were healthy and free from rheumatoid arthritis, rheumatic fever, or any other recognizable systemic disease at followup and none had positive tests for antinuclear antibodies or rheumatoid factors. Histologically the nodules closely resembled those seen in adult-onset rheumatoid arthritis. Though biopsy may be useful for confirmation of the clinical diagnosis of benign rheumatoid nodules, wide surgical excision, skin grafting, and treatment with medication are unnecessary in this selflimited syndrome.

scholarly journals AB0058 ASSOCIATION BETWEEN HLA-DRB1*04:01, RHEUMATOID NODULES AND PARTICULAR EPITOPES OF CITRULLINATED FIBRIN IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1061.1-1061
Author(s):  
G. Larid ◽  
M. Pancarte ◽  
G. Offer ◽  
C. Clavel ◽  
M. Martin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Amino Acid ◽  
Antigen Processing ◽  
Rheumatoid Factors ◽  
Post Translational Modification ◽  
Human Fibrinogen ◽  
Rheumatoid Nodules ◽  
Genes Encoding ◽  
High Level ◽  
Almost All

Background:Rheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5 amino acid motive. RA is usually preceded by the emergence of anti-citrullinated protein antibodies (ACPAs) detected by anti-CCP2 tests. Citrullin is a neutral amino acid resulting from post translational modification of arginin by Peptidyl Arginyl Deiminases (PADs). ACPAs recognize epitopes from citrullinated human fibrinogen (Fib-cit) and can be specifically detected by the AhFibA assay. Five peptides derived from Fib-cit together represent almost all of the epitopes recognized by patients with ACPA-positive RA: β60–74cit, α36–50cit, α621–635cit, α501–515cit and α171–185cit. As RA is a pleiomorphic disease, whose evolution is difficult to predict, the use of antibody fine specificity as a marker of clinical phenotypes has become a major challenge.Objectives:Our objective was to study whether clinical characteristics and HLA-DRB1 genetic background were associated with a specific reactivity against these epitopes.Methods:184 ACPA positive RA patients fulfilling the 2010 ACR/EULAR criteria were studied. Patients characteristics, including HLA-DRB1 genotype, were collected from their medical files. Anti-CCP2, AhFibA, Rheumatoid Factors (RF), and antibodies against the five major Fib-cit peptides were analyzed using ELISA assays.Results:Anti-CCP2 and AhFibA titres were strongly correlated (rs: 0.7037; p = 5.69x10-29, Pearson’s). Anti-α505-515cit antibodies were associated with HLA-DRB1*04:01 (OR = 5.52 [2.00 – 13.64]; p = 0.0003). High level anti-α505-515cit antibodies were significantly associated with rheumatoid nodules (OR = 2.71 [1.00 – 7.16], p= 0.044). Anti α501–515cit antibodies were associated with RF (OR=2.31 [1.10 – 4.78], p= 0.026).Conclusion:Immune complexes containing anti-α501–515cit antibodies and rheumatoid factors might be involved in the development of rheumatoid nodules on the HLA-DRB1*04:01 background. These findings highlight the role played by the HLA-DRB1*04:01 molecule and its rapid intracellular route into the lysosomes, enabling original antigen processing. Finally, purifying these epitope specific antibodies might be a new therapeutic opportunity for rheumatoid nodules.Disclosure of Interests:None declared

Juvenile Rheumatoid Arthritis: A Review

PEDIATRICS ◽  
1972 ◽  
Vol 50 (6) ◽  
pp. 940-953
Author(s):  
Jane Schaller ◽  
Ralph J. Wedgwood
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Juvenile Rheumatoid Arthritis ◽  
Common Property ◽  
Antinuclear Antibodies ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Latex Agglutination ◽  
Hand Joints ◽  
Small Hand

Juvenile rheumatoid arthritis (JRA) is a disease of varying clinical manifestations, although all patients share the common property of arthritis. In following 124 children with JRA at a children's arthritis clinic (mean disease duration, 7.5 years), it was apparent that there were three distinct subgroups of disease distinguished by their clinical manifestations, prognosis for joint disability, types of extra-articular complications, and serologic findings. Systemic disease, characterized by high intermittent fevers and rheumatoid rash as well as other systemic manifestations, occurred in 32 of 124 patients (26%). All patients also had polyarthritis, generally beginning during the first six months of disease. More boys (18) than girls (14) were affected. No patient had iridocyclitis or positive tests for antinuclear antibodies or rheumatoid factor. Systemic symptoms alone were not a cause of permanent morbidity, but eight of 32 patients have incurred severe joint disability. Polyarticular disease unassociated with prominent systemic disease occurred in 46 of 124 patients (37%), predominantly girls (38 girls, eight boys). Multiple joints were involved, characteristically including small hand joints. Ten patients had antinuclear antibodies; six had positive latex agglutination tests for rheumatoid factor. Eight of 46 had severe joint disability. Persistent pauciarticular disease, characterized by arthritis limited to five or fewer joints, occurred in 46 of 124 patients (37%), predominantly girls (34 girls, 12 boys). Large joints were chiefly affected (knees, ankles, elbows); small hand joints were spared. Nine of 46 patients had antinuclear antibodies. No patient has had severe joint disability, but 12 of 46 have had iridocyclitis and ten have suffered some degree of permanent visual damage. Recognition of these disease patterns is useful in the diagnosis and care of children with JRA. Furthermore, these observations suggest that what we now call JRA may in fact be more than a single disease.

Acute- or Subacute-Onset Lung Complications in Treating Patients with Rheumatoid Arthritis

2013 ◽  
Vol 64 (3) ◽  
pp. 200-207 ◽  
Author(s):  
Reiko Nakajima ◽  
Fumikazu Sakai ◽  
Toshihide Mimura ◽  
Hitoshi Tokuda ◽  
Masahiro Takahashi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
Interstitial Pneumonia ◽  
Inflammatory Arthritis ◽  
Systemic Disease ◽  
Airway Disease ◽  
Drug Induced ◽  
Pleural Diseases ◽  
Rheumatoid Nodules ◽  
Pictorial Review

Rheumatoid arthritis (RA) is a common systemic disease that manifests as inflammatory arthritis of multiple joints and produces a wide variety of intrathoracic lesions, including pleural diseases, diffuse interstitial pneumonia, rheumatoid nodules, and airway disease. Patients treated for RA can have associated lung disease that commonly manifests as diffuse interstitial pneumonia, drug-induced lung injury, and infection. The purpose of this pictorial review is to illustrate the radiographic and clinical features of lung complications of acute or subacute onset in patients treated for RA and to show the computed tomography features of these complications.

Rheumatoid Arthritis: History, Stages, Epidemiology, Pathogenesis, Diagnosis and Treatment

2017 ◽  
Vol 9 (02) ◽  
Author(s):  
Abeer Fauzi Al-Rubaye ◽  
Mohanad Jawad Kadhim ◽  
Imad Hadi Hameed
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Systemic Disease ◽  
Modern Medicine ◽  
Whole Body ◽  
Internal Organs ◽  
Synthetic Drugs ◽  
Relieve Pain ◽  
Medicinal Treatment ◽  
Natural Drugs

The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs. Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and internal organs such as lungs, heart and eyes. Although numbers of synthetic drugs are being used as standard treatment for rheumatoid arthritis but they have adverse effect that can compromise the therapeutic treatment. Unfortunately, there is still no effective known medicinal treatment that cures rheumatoid arthritis as the modern medicine can only treat the symptoms of this disease that means to relieve pain and inflammation of joints. It is possible to use the herbs and plants in various forms in order to relieve the pain and inflammation in the joints. There are so many medicinal plants that have shown anti rheumatoid arthritis properties. So the plants and plant product with significant advantages are used for the treatment of rheumatoid arthritis. The present review is focused on the medicinal plants having anti rheumatoid arthritis activity

Analysis of Monoclonal Rheumatoid Factors obtained from the B-Cell Repertoire in Rheumatoid Arthritis

1992 ◽  
Vol 35 (2) ◽  
pp. 149-157 ◽  
Author(s):  
M. ABDERRAZIK ◽  
M. MOYNIER ◽  
R JEFFFRIS ◽  
R. A. K. MAGEED ◽  
B. COMBE ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cell ◽  
Rheumatoid Factors ◽  
Cell Repertoire ◽  
B Cell Repertoire

"Pseudorheumatoid" Nodules in Children: Report of 10 Cases

PEDIATRICS ◽  
1970 ◽  
Vol 45 (3) ◽  
pp. 473-478 ◽  
Author(s):  
John D. Burrington
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Inflammatory Cells ◽  
Granuloma Annulare ◽  
Subcutaneous Nodules ◽  
Rheumatoid Nodules ◽  
Clinical Variant ◽  
Ulnar Aspect ◽  
Palm Of The Hand

Subcutaneous nodules, composed of necrotic collagen surrounded by chronic inflammatory cells, occur in about 20% of individuals with rheumatoid arthritis, 10% of those with acute rheumatic fever, and 25% of children with granuloma annulare. Similar subcutaneous lesions indistinguishable from rheumatoid nodules may appear in children who do not develop other stigmata of disease. Mesara and ous lesions of granuloma annulare. Therefore, they felt that, in children, these nodules probably represented a clinical variant of granuloma annulare. Beatty3 described nine children aged 11 days to 9 years with nodules on the scalp, ulnar aspect of the arm, dorsum of the foot, and palm of the hand which appeared histologically to be rheumatoid nodules.

Rheumatoid Factors and Rheumatoid Arthritis

1988 ◽  
Vol 17 (sup74) ◽  
pp. 41-44 ◽  
Author(s):  
Kimmo Aho ◽  
Tiinamaija Tuomi ◽  
Markku Heliövaara ◽  
Timo Palosuo
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factors

scholarly journals Groin Flap for Salvage of Upper Extremity Following Necrotizing Fasciitis: A Case Report

2005 ◽  
Vol 13 (3) ◽  
pp. 153-155
Author(s):  
Chenicheri Balakrishnan ◽  
Venkata S Erella ◽  
Shawn Vandemark ◽  
Jason Mussman
Keyword(s):  
Upper Extremity ◽  
Soft Tissues ◽  
Skin Grafting ◽  
Surgical Excision ◽  
Soft Tissue Infections ◽  
Significant Morbidity ◽  
Groin Flap ◽  
Necrotizing Soft Tissue Infections ◽  
Extensive Debridement ◽  
The Common

Necrotizing soft tissue infections are often associated with significant morbidity and mortality Early surgical excision along with antibiotic therapy is the cornerstone of management. Salvage of these extremities is often difficult due to loss of soft tissues, tendons, nerves and blood vessels. Skin grafting of the granulating wound is the common method of closure in these patients. Use of various flaps has improved reconstructive options in these extremities. A case of salvage of upper extremity using a groin flap following extensive debridement is reported.

Sign in / Sign up

Export Citation Format

Share Document