Excessive dietary vitamin D supplementation as a risk factor for sudden death syndrome in fast growing commercial broilers

2007 ◽  
Vol 148 (4) ◽  
pp. 828-833 ◽  
Author(s):  
S. Nain ◽  
B. Laarveld ◽  
C. Wojnarowicz ◽  
A.A. Olkowski
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Sudden Death ◽  
Vitamin D Supplementation ◽  
Sudden Death Syndrome ◽  
Dietary Vitamin ◽  
Fast Growing ◽  
Dietary Vitamin D

scholarly journals Effects of Vitamin D Supplementation on 1, 25-dihydroxyvitamin D Metabolism and Its Impact on Adipose Tissue Inflammation in Obese Mice (P24-004-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Chan Yoon Park ◽  
Shuang Zhu ◽  
Young Sun Jung ◽  
Sung Nim Han
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Vitamin D Supplementation ◽  
Dietary Vitamin ◽  
Epididymal Adipose Tissue ◽  
Mrna Levels ◽  
Obese Mice ◽  
Dihydroxyvitamin D ◽  
Vitamin D Levels ◽  
Dietary Vitamin D

Abstract Objectives Adipose tissue expresses CYP27B1 and VDR, suggesting local metabolism and function of 1,25-dihydroxyvitamin D (1,25(OH)2D) in adipose tissue. Obesity has been associated with dysregulation of 1,25(OH)2D levels. We investigated effects of vitamin D supplementation on 1,25(OH)2D metabolism and its impact in adipose tissue of obese mice. Methods Six-wk-old C57BL/6 mice were divided into 4 groups and fed experimental diets containing 10% or 45% kcal fat (CON or HFD) and differing in vitamin D content (1000 or 25,000 IU/kg of diet, DC or DS) for 13 wks. Serum 1,25(OH)2D and PTH levels were determined with radio- or enzyme-immunoassay. The mRNA levels of Cyp27b1, Cyp24a1, and Lrp2 in the kidney, and Cyp27b1, Vdr, and pro-inflammatory cytokines (Mcp-1, Rantes, Mip-1γ, Tnf-α, Il-6, Il-1β, and Ifn-γ) in the epididymal adipose tissue were determined by real-time PCR. Results Overall, serum 1,25(OH)2D levels were higher in DS groups compared with DC groups. When 1,25(OH)2D levels were compared between CON and HFD groups, differential pattern was observed depending on vitamin D levels in the diet. HFD-DC group showed higher serum 1,25(OH)2D and PTH levels compared with CON-DC group. However, in the DS groups, serum 1,25(OH)2D and PTH levels were not significantly affected by dietary fat amount. Renal Cyp24a1 mRNA levels, which could be up-regulated by dietary vitamin D, was higher in CON-DS group compared with CON-DC group. However, in the HFD groups, renal Cyp24a1 mRNA levels were similar in DC and DS groups. Mcp-1 and Rantes mRNA levels were higher in the HFD groups compared with CON groups, and their overall expression levels were down-regulated by vitamin D supplementation. Overall, mRNA levels of Il-6 and Il-1β were lower in the DS groups compared with DC groups. Conclusions Dietary vitamin D supplementation alleviated inflammatory responses in adipose tissue. Both 1,25(OH)2D in circulation and locally produced 1,25(OH)2D in adipose tissue might have contributed to the effect. Funding Sources Supported by the grant from the National Research Foundation (NRF) of Korea (NRF-2018R1D1A1B070491).

Assessment of Dietary Vitamin D Intake and Compliance With Recommended Vitamin D Supplementation in Division I Collegiate Athletes

2015 ◽  
Vol 7 (5) ◽  
pp. 204-213
Author(s):  
M. Alison Brooks ◽  
Rachel B. Parks ◽  
Jennifer L. Sanfilippo ◽  
Neil C. Binkley ◽  
Mikel R. Stiffler
Keyword(s):  
Vitamin D ◽  
Collegiate Athletes ◽  
Vitamin D Supplementation ◽  
Division I ◽  
Dietary Vitamin ◽  
Vitamin D Intake ◽  
Dietary Vitamin D

Abstract MP58: Vitamin D Consumption is Not Associated with Incident Heart Failure: the Physicians' Health Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Jeremy Robbins ◽  
Andrew Petrone ◽  
J. Michael Gaziano ◽  
Luc Djousse
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Cox Regression ◽  
Linear Trend ◽  
Vitamin D Supplementation ◽  
Health Study ◽  
Dietary Vitamin ◽  
Breakfast Cereal ◽  
Incident Heart Failure ◽  
Dietary Vitamin D

Background: Previous research investigating the relationship between vitamin D supplementation and incident heart failure (HF) has yielded equivocal results. Limited research exists on the association of dietary vitamin D consumption and the risk of incident heart failure. Objective: We sought to test the hypothesis that vitamin D consumption is associated with a lower incidence of heart failure. Methods and Results: Using a validated food frequency questionnaire, we estimated dietary vitamin D consumption for 19,635 participants of the Physician’s Health Study who were free of HF at baseline. The mean age at baseline was 66.4 ± 9.2 years. Over a mean followup of 9.3 years, 858 cases of incident HF were captured using an annual follow-up questionnaire with validation in a subsample. From the multivariable Cox regression model, hazard ratios (95% CI) of incident HF were 1.0 (reference), 1.49 (1.17 to 1.89), 1.37 (1.07 to 1.75), 1.34 (1.02 to 1.75), and 1.28 (0.94 to 1.75) from lowest to highest quintile of calorie-adjusted vitamin D, respectively, after adjusting for age, BMI, smoking, alcohol, exercise, multivitamin use, fruits and vegetables, chocolate, and breakfast cereal consumption, atrial fibrillation, and valvular heart disease (p for linear trend = 0.71). Conclusions: In this prospective study of male health professionals, dietary vitamin D consumption is associated with a higher risk of HF.

scholarly journals A 250 μg/week dose of vitamin D was as effective as a 50 μg/d dose in healthy adults, but a regimen of four weekly followed by monthly doses of 1250 μg raised the risk of hypercalciuria

2013 ◽  
Vol 110 (10) ◽  
pp. 1866-1872 ◽  
Author(s):  
Sara R. Zwart ◽  
Howard Parsons ◽  
Michael Kimlin ◽  
Sheila M. Innis ◽  
James P. Locke ◽  
...  
Keyword(s):  
Vitamin D ◽  
Side Effects ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Healthy Adults ◽  
Dietary Vitamin ◽  
Steady Increase ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

The risk of vitamin D insufficiency is increased in persons having limited sunlight exposure and dietary vitamin D. Supplementation compliance might be improved with larger doses taken less often, but this may increase the potential for side effects. The objective of the present study was to determine whether a weekly or weekly/monthly regimen of vitamin D supplementation is as effective as daily supplementation without increasing the risk of side effects. Participants were forty-eight healthy adults who were randomly assigned for 3 months to placebo or one of three supplementation regimens: 50 μg/d (2000 IU/d, analysed dose 70 μg/d), 250 μg/week (10 000 IU/week, analysed dose 331 μg/week) or 1250 μg/week (50 000 IU/week, analysed dose 1544 μg/week) for 4 weeks and then 1250 μg/month for 2 months. Daily and weekly doses were equally effective at increasing serum 25-hydroxyvitamin D, which was significantly greater than baseline in all the supplemented groups after 30 d of treatment. Subjects in the 1250 μg treatment group, who had a BMI >26 kg/m2, had a steady increase in urinary Ca in the first 3 weeks of supplementation, and, overall, the relative risk of hypercalciuria was higher in the 1250 μg group than in the placebo group (P= 0·01). Although vitamin D supplementation remains a controversial issue, these data document that supplementing with ≤ 250 μg/week ( ≤ 10 000 IU/week) can improve or maintain vitamin D status in healthy populations without the risk of hypercalciuria, but 24 h urinary Ca excretion should be evaluated in healthy persons receiving vitamin D3 supplementation in weekly single doses of 1250 μg (50 000 IU).

scholarly journals Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model

2021 ◽  
Author(s):  
Mayara C. Ribeiro ◽  
Jessica L. MacDonald
Keyword(s):  
Vitamin D ◽  
Rett Syndrome ◽  
Vitamin D Supplementation ◽  
Neuronal Morphology ◽  
Dietary Vitamin ◽  
Projection Neurons ◽  
Behavioral Phenotypes ◽  
Vitamin D Levels ◽  
Dendritic Complexity ◽  
Dietary Vitamin D

Rett syndrome (RTT) is an X-linked neurological disorder caused by mutations in the transcriptional regulator MECP2. Mecp2 loss-of-function leads to the disruption of many cellular pathways, including aberrant activation of the NF-κB pathway. Genetically attenuating the NF-κB pathway in Mecp2-null mice ameliorates hallmark phenotypes of RTT, including reduced dendritic complexity, raising the question of whether NF-κB pathway inhibitors could provide a therapeutic avenue for RTT. Vitamin D is a known inhibitor of NF-κB signaling; further, vitamin D deficiency is prevalent in RTT patients and male Mecp2-null mice. We previously demonstrated that vitamin D rescues the aberrant NF-κB activity and reduced neurite outgrowth of Mecp2-knockdown cortical neurons in vitro, and that dietary vitamin D supplementation rescues decreased dendritic complexity and soma size of neocortical projection neurons in both male hemizygous Mecp2-null and female heterozygous mice in vivo. Here, we have identified over 200 genes whose dysregulated expression in the Mecp2+/- cortex is modulated by dietary vitamin D. Genes normalized with vitamin D supplementation are involved in dendritic complexity, synapses, and neuronal projections, suggesting that the rescue of their expression could underpin the rescue of neuronal morphology. Further, motor and anxiety-like behavioral phenotypes in Mecp2+/- mice correlate with circulating vitamin D levels, and there is a disruption in the homeostasis of the vitamin D synthesis pathway in Mecp2+/- mice. Thus, our data indicate that vitamin D modulates RTT pathology and its supplementation could provide a simple and cost-effective partial therapeutic for RTT.

scholarly journals Dietary vitamin D supplementation attenuates immune responses of pigs challenged with rotavirus potentially through the retinoic acid-inducible gene I signalling pathway

2014 ◽  
Vol 112 (3) ◽  
pp. 381-389 ◽  
Author(s):  
Ye Zhao ◽  
Bing Yu ◽  
Xiangbing Mao ◽  
Jun He ◽  
Zhiqing Huang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Retinoic Acid ◽  
Vitamin D Supplementation ◽  
Signalling Pathway ◽  
Intestinal Morphology ◽  
Dietary Vitamin ◽  
Control Serum ◽  
Challenge Control ◽  
Dietary Vitamin D ◽  
Inducible Gene

In the present study, twenty-four Duroc × Landrance × Yorkshire (initial body weight (BW) of 21·82 (sem2·06) kg) cross-bred pigs were used to determine whether dietary vitamin D supplementation could confer protection against viral infections through the retinoic acid-inducible gene I (RIG-I) signalling pathway in pigs. Experimental treatments were arranged in a 2 × 2 factorial manner with the main effects of immune challenge (controlv.porcine rotavirus (PRV) challenge) and dietary concentrations of vitamin D (200 and 5000 IU; where 1 IU of vitamin D is defined as the biological activity of 0.025 mg of cholecalciferol). The pigs were fed a diet containing 200 or 5000 IU vitamin D in the first week of the study period. On day 8, the pigs were orally dosed with 4 ml of Dulbecco's modified Eagle's medium/Ham's F-12 medium containing PRV or essential medium (control). Serum samples were collected on day 8 (pre-challenge), and 6 d after the PRV challenge, the pigs were killed to evaluate intestinal morphology and tissue gene expression following the last blood collection. Pigs challenged with PRV had decreased BW gain (P< 0·01), feed intake (P< 0·01), villus height (P< 0·01), faecal consistency (P< 0·05), and serum 1,25-dihydroxyvitamin D concentration (P< 0·01) and increased (P< 0·01) serum IL-2, IL-6 and interferon (IFN)-β concentrations. Vitamin D supplementation mitigated these effects. The mRNA expression ofRIG-I(P< 0·01), IFN-β promoter stimulator 1 (P< 0·01),IFN-β(P< 0·01) and interferon-stimulated gene 15 (ISG15) (P< 0·01) was up-regulated by the PRV challenge and vitamin D supplementation in the intestine. In conclusion, vitamin D supplementation could activate the RIG-I signalling pathway and thus alleviate the negative effects caused by PRV challenge.

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