Hypotonic stress alters expression of genes encoding transcription factors, protein homeostasis enzymes, mitochondrial proteins, and transport proteins in gills of the euryhaline green crab (Carcinus maenas)

Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary, and mammary glands. How secretory capacity is selectively up-regulated in specialized secretory cells is unknown. Here, we find that the CrebA/Creb3-like family of bZip transcription factors functions to up-regulate expression of both the general protein machinery required in all cells for secretion and of cell type–specific secreted proteins. Drosophila CrebA directly binds the enhancers of secretory pathway genes and is both necessary and sufficient to activate expression of every secretory pathway component gene examined thus far. Microarray profiling reveals that CrebA also up-regulates expression of genes encoding cell type–specific secreted components. Finally, we found that the human CrebA orthologues, Creb3L1 and Creb3L2, have the ability to up-regulate the secretory pathway in nonsecretory cell types.

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TCP Transcription Factors Link the Regulation of Genes Encoding Mitochondrial Proteins with the Circadian Clock in Arabidopsis thaliana

The Plant Cell ◽

10.1105/tpc.110.074518 ◽

2010 ◽

Vol 22 (12) ◽

pp. 3921-3934 ◽

Cited By ~ 92

Author(s):

Estelle Giraud ◽

Sophia Ng ◽

Chris Carrie ◽

Owen Duncan ◽

Jasmine Low ◽

...

Keyword(s):

Arabidopsis Thaliana ◽

Transcription Factors ◽

Circadian Clock ◽

Mitochondrial Proteins ◽

Genes Encoding

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Regulation of gene expression in oncogenically transformed cells

Biochemistry and Cell Biology ◽

10.1139/o92-142 ◽

1992 ◽

Vol 70 (10-11) ◽

pp. 980-997 ◽

Cited By ~ 8

Author(s):

Mohammed Dehbi ◽

Pierre-André Bédard

Keyword(s):

Gene Expression ◽

Transcription Factors ◽

Transcriptional Activation ◽

Cell Transformation ◽

Regulation Of Gene Expression ◽

Constitutive Expression ◽

Transformed Cells ◽

Extracellular Proteases ◽

Expression Of Genes ◽

Genes Encoding

Several genes expressed in response to growth factors are also regulated aberrantly in oncogenically transformed cells. The constitutive expression of genes encoding extracellular proteases, transcription factors, and cytokines is often correlated with cell transformation. In several instances, the uncontrolled expression of these genes is the result of transcriptional activation. Therefore, much attention has been devoted to the study of promoter function in transformed cells. We now review the results of recent investigations on transformation-dependent gene expression. The activation of several transcription factors in oncogenically- transformed cells is described. Results regarding the regulation of promoters through PRD II/κB are presented for cells transformed by a variety of oncogenes. Finally, we discuss the significance of transcription factor activation in the process of cell transformation.Key words: oncogenes, transcription factors, transformation, pp60v-src.

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