Vitamin D & cardiac autonomic neuropathy in newly diagnosed type 2 diabetics : A pilot study

2019 ◽  
Vol 493 ◽  
pp. S283-S284
Author(s):  
R. Sharma ◽  
P. Sharma ◽  
S. Sharma ◽  
S. Ravichandran ◽  
P. Kamble ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Newly Diagnosed ◽  
Type 2 Diabetics

scholarly journals Association of vitamin-D deficiency with oxidative stress in newly diagnosed type 2 diabetes

2017 ◽  
Vol 5 (12) ◽  
pp. 5221
Author(s):  
Bairapogu John Pradeep Kumar ◽  
Maliyannar Itaggappa ◽  
Kamandalagondi Vasudevareddy Thimmaraju
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Oxidative Stress Markers ◽  
Newly Diagnosed ◽  
Stress Markers ◽  
Type 2 Diabetics ◽  
Vitamin D Levels

Background: According to a recent World Health Organization (WHO) report, India, with 32 million diabetic individuals, currently has the highest incidence of diabetes worldwide; these numbers are predicted to increase to 80 million by the year 2030. Deficiency of vitamin D has been associated with increased risk of developing Type 2 diabetes mellitus (DM) and cardiovascular diseases. Vitamin D deficiency is highly prevalent in our country. About 70% of adults in both rural and urban areas were found showing manifestations of vitamin D deficiency. Therefore, we designed this study to assess the vitamin D status of the study population by measuring serum 25(OH) D levels, and its association with oxidative stress markers in type 2 diabetes mellitus.Methods: This is a cross sectional study with Group 1 (n=147): Newly diagnosed type 2 diabetics and Group 2 (n=147): Apparently healthy individuals. Blood was collected by venipuncture. 5ml of blood was collected and allowed to clot. Serum was separated and stored in refrigerator to estimate the oxidative stress markers and vitamin D levels. Estimation of vitamin D levels and oxidative stress markers were carried out by commercially available kits.Results: Vitamin D levels are significantly low in newly diagnosed type 2 diabetics when compared to controls (p < 0.000), whereas the FBG levels are significantly high in newly diagnosed type 2 diabetics when compared to controls (p < 0.000). The TAOS levels are significantly low in newly diagnosed type 2 diabetics when compared to controls (p <0.000), whereas the MDA levels are significantly high in newly diagnosed type 2 diabetics when compared to controls (p < 0.000). The oxidative stress marker TAOS (r = 0.71; p < 0.000), was positively correlated and MDA (r = - 0.85; p < 0.000), was negatively with Vitamin D in newly diagnosed type 2 diabetics.Conclusions: From this study, it is concluded that, lower levels of vitamin D is associated with increased oxidative stress. Therapeutic interventions to increase the vitamin D levels and reduce the oxidative stress should be included as a part of treatment inn newly diagnosed type diabetics.

scholarly journals To study the impact of glycemic control over cardiac autonomic neuropathy in type 1 and type 2 diabetics patients using bedside tests at a tertiary care hospital

2017 ◽  
Vol 4 (3) ◽  
pp. 635
Author(s):  
Sumaiya Anjum ◽  
Suresh K.
Keyword(s):  
Glycemic Control ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Glycemic Status ◽  
Type 2 Diabetics ◽  
The Impact

Background: Cardiac autonomic neuropathy a serious complication of diabetes and is often overlooked. It is associated with higher cardiovascular mortality and poor quality of life in diabetic individuals. The Glycemic control has been well established as the risk factor for all the diabetes related microvascular and macrovascular complications. This stresses importance of role of glycemic control over CAN in Type 1 and Type 2 Diabetics in order to stop further progression to advanced and irreversible stages. The objective was to study the impact of various demographic and other clinical factors over prevalence of CAN in type 1 and type 2 diabetic patients who are asymptomatic for CAN using bedside testsMethods: A case control comparative clinical study was undertaken comprising of 100 diabetic patients, both type 1 and type 2 with duration from 5-10 years and >10 years. The tests which were performed are deep breathing test, heart rate response to standing, hand grip test, cold pressor test, BP response to standing. Depending on these tests, patients were categorised as patients with cardiac autonomic neuropathy and without cardiac autonomic neuropathy.Results: The prevalence of cardiac dysautonomia was 68%. Type 2 diabetics had higher prevalence of cardiac dysautonomia than type 1 diabetics (p=0.025). Significant correlation was observed between cardiac autonomic neuropathy and poor glycemic status (type 1 p<0.001; type 2 p<0.001). The mean HbA1c in patients with and without CAN in type 1DM was 9.16+0.81 and 7.21+0.56 and in type 2 DM was 9.15+1.72 and 7.15+0.53 respectively. Similarly, presence of other microvascular complications increased the prevalence of CAN in both types of diabetes mellitus.Conclusions: Cardiac autonomic neuropathy is a common complication in long standing diabetes. Present results suggest that glycemic status of the diabetics is undoubtedly an important factor for the onset of cardiac dysautonomia which in turn account for high prevalence of cardiac mortality in diabetic patients. All asymptomatic diabetic patients should be evaluated for the presence of autonomic neuropathy and glycemic status should be controlled to prevent the further progression of CAN.

scholarly journals Alternations in serum vitamin D, calcium, phosphorus and lipid profile levels in newly diagnosed type 2 diabetic patients of North-West India

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 189-193
Author(s):  
Kuldip Singh ◽  
Asha Khubchandani ◽  
Sarbjot Singh
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetics ◽  
Healthy Control ◽  
Type 2 Diabetic

Introduction and Aim: Thirty-two million Indians are suffering with diabetes mellitus worldwide and predicted that this number of diabetes to be increased to 80 million by 2030. Many reports revealed a positive relationship between diabetic patients suffering with 25 (OH) D deficiency. In developing nations like India 60% adults were found showing manifestations of vitamin D deficiency and dyslipidemia, a well-known risk factor for the development of diabetes mellitus. Therefore, we designed the study to evaluate alterations in vitamin D, calcium, and phosphorus along with complete lipid profile levels in newly diagnosed type 2 diabetic patients in North-West Indians.Materials and Methods: One hundred fifty newly diagnosed type 2 diabetic patients and equal number of healthy control subjects of both genders were recruited in the study. 5ml of blood was collected by venipuncture after 12-14 hours fasting in plain and potassium oxalate: sodium fluoride vial. Serum and plasma were separated and used for the determination of 25(OH) D levels, calcium, phosphorus and complete lipid profile levels.Results: A significantly (p < 0.001) high level of glucose was observed in newly diagnosed type 2 diabetics subjects while a significant fall (p < 0.001) was recorded in vitamin D levels in newly diagnosed type 2 diabetics in comparison to healthy control subjects. The nominal changes were seen in calcium and phosphorus levels in newly diagnosed type 2 diabetics with respect to healthy control subjects. Statistically significant increase was found in total cholesterol (p < 0.05), triglyceride (p < 0.001) and VLDL-cholesterol (p < 0.001) levels while no significant changes was observed in LDL- cholesterol and HDL- cholesterol levels in newly diagnosed type 2 diabetics with respect to healthy subjects.Conclusion: Aforementioned observations suggested that a significant decrease in vitamin D levels was associated with increased glucose and lipid levels like total cholesterol, triglycerides and VLDL-cholesterol levels could be responsible for the initiation of various diseases like diabetes mellitus, cardiovascular diseases, osteoporosis etc. Hence, new interventions should be included as a part of treatment to reduce the risk of type-2 diabetics and CVDs like atherosclerosis

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