Liquid-liquid extraction of lactic acid using non-toxic solvents

2022 ◽  
pp. 100823
Author(s):  
Danish Beg ◽  
Anuj Kumar ◽  
Diwakar Shende ◽  
Kailas Wasewar
Keyword(s):  
Lactic Acid ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction

Hydrophobic Deep Eutectic Solvents for the Recovery of Bio-Based Chemicals: Solid–Liquid Equilibria and Liquid–Liquid Extraction

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 796
Author(s):  
Thomas Brouwer ◽  
Bas C. Dielis ◽  
Jorrit M. Bock ◽  
Boelo Schuur
Keyword(s):  
Lactic Acid ◽  
Formic Acid ◽  
Levulinic Acid ◽  
Deep Eutectic Solvents ◽  
Liquid Extraction ◽  
Lewis Base ◽  
Trioctylphosphine Oxide ◽  
Base Interaction ◽  
Liquid Liquid Extraction ◽  
Solid Liquid

The solid–liquid equilibrium (SLE) behavior and liquid–liquid extraction (LLX) abilities of deep eutectic solvents (DESs) containing (a) thymol and L-menthol, and (b) trioctylphosphine oxide (TOPO) and L-menthol were evaluated. The distribution coefficients (KD) were determined for the solutes relevant for two biorefinery cases, including formic acid, levulinic acid, furfural, acetic acid, propionic acid, butyric acid, and L-lactic acid. Overall, for both cases, an increasing KD was observed for both DESs for acids increasing in size and thus hydrophobicity. Furfural, being the most hydrophobic, was seen to extract the highest KD (for DES (a) 14.2 ± 2.2 and (b) 4.1 ± 0.3), and the KD of lactic acid was small, independent of the DESs (DES (a) 0.5 ± 0.07 and DES (b) 0.4 ± 0.05). The KD of the acids for the TOPO and L-menthol DES were in similar ranges as for traditional TOPO-containing composite solvents, while for the thymol/L-menthol DES, in the absence of the Lewis base functionality, a smaller KD was observed. The selectivity of formic acid and levulinic acid separation was different for the two DESs investigated because of the acid–base interaction of the phosphine group. The thymol and L-menthol DES was selective towards levulinic acid (Sij = 9.3 +/− 0.10, and the TOPO and L-menthol DES was selective towards FA (Sij = 2.1 +/− 0.28).

scholarly journals Molecular toxicity of potential liquid membranes for lactic acid removal from fermentation broths using Lactobacillus casei ATCC 393

DYNA ◽  
2018 ◽  
Vol 85 (207) ◽  
pp. 360-366 ◽  
Author(s):  
Alan D. Pérez Ávila ◽  
Sneyder Rodríguez-Barona ◽  
Javier Fontalvo-Alzate
Keyword(s):  
Lactic Acid ◽  
Lactobacillus Casei ◽  
Lactic Acid Production ◽  
Glucose Consumption ◽  
Extraction Process ◽  
Liquid Extraction ◽  
Liquid Membranes ◽  
Aliquat 336 ◽  
Liquid Liquid Extraction ◽  
Molecular Toxicity

Toxic effects of extractants and carriers of specific microorganisms must be taken into account before using them with hybrid fermentation processes that are combined with liquid membranes or liquid-liquid extraction. In the current research three extractants (trioctylamine, tri-iso-octylamine and Aliquat 336), three diluents (dodecane, dodecanol, and oleyl alcohol) and two mixtures (extractant/diluent) were tested for molecular toxicity on the bacteria Lactobacillus casei ATCC 393 as potential components of a liquid membrane or a liquid-liquid extraction process for lactic acid removal in an intensified fermentation process. Glucose consumption, lactic acid production, and cell growth were used as toxicity indicators. Physical properties of extractants and diluents were related to the molecular toxicity on the microorganism. These results show that mixtures of tri-iso-octylamine/dodecane and trioctylamine/dodecane at a proportion of 1:9 v/v have great potential to be used in liquid membranes or liquid-liquid extraction processes on hybrid fermentations with Lactobacillus casei ATCC 393.

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