The existing method for selecting the structure of a power plant for thermally recycling municipal solid waste (MSW) in the Russian Federation does not address the matter of selecting all components of an energy complex operating on MSW, but places focus on determining the best accessible waste thermal neutralization technology. This generates the need to search for new methods and to select criteria of choosing the structure for each particular project. A comparative analysis of various structural schemes of waste-to-energy plants widely used outside of Russia will make it possible to reveal their main advantages and drawbacks, and to determine their application fields. The article describes the statistical indicators characterizing the operation of the flue gas purification system from acid gases, which can be applied in performing a feasibility study, intellectual property assessment, and in carrying out front-end engineering. For waste-to-energy plants constructed in an urban environment and aimed to operate with keeping to a minimum the gross emissions of acid gases into the atmospheric air, the use of a wet reactor system is recommended, which will ensure low emissions of HF, HCl, and SOx. The system with a wet reactor will make it possible to reduce gross emissions of harmful substances during the operation of large capacity waste-to-energy power plants and will be a justified choice in such case. In constructing medium capacity waste-to-energy plants (with a throughput of up to 350 000 t of MSW per annum), semi-dry and dry reactors can be used; for such plants, the technology involving the use of a semi-dry reactor is the most preferred one.