Bifunctional Co3O4-La2O2CO3@C derived from MOFs for peroxymonosulfate activation to degrade roxarsone and simultaneously removal of released inorganic arsenic from water

The purpose of the present study was to assess arsenic (As) speciation in rice from West Bengal, India, in order to improve understanding of the health risk posed by arsenic in Indian rice. Rice is a potentially important route of human exposure to arsenic, especially in populations with rice-based diets. However, arsenic toxicity varies greatly with species. Determination of arsenic (As) species in rice is necessary because inorganic As species are more toxic than organic As. Total arsenic was determined by inductively coupled plasma mass spectrometry; arsenite, arsenate, monomethylarsonic acid, and dimethyarsinic acid were quantified by high-performance liquid chromatography- inductively coupled plasma mass spectrometry. The analysis of a rice flour certified reference material (SRM-1568-a) were evaluated for quality assurance. The use of 2M TFA for extraction with an isocratic mobile phase was optimized for extraction and employed for arsenic speciation in rice. The extraction method showed a high recovery of arsenic. Most of the As species in rice were noticed to be inorganic [Arsenite (As-III), Arsenate As-V]. It appeared very clear from the present study that inorganic arsenic shared maximum arsenic load in rice straw while in grains it is considerably low. As species recovered from rice grain and straw are principally As-III and As-V with a little share of DMA and almost non-detectable MMA and As-B. The order of As species in rice grain revealed in this study were As-III (54.5-65.4 %)>As-V(21.2-28.3%)>DMA(5.2%).

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Association of arsenic-induced cardiovascular disease susceptibility with genetic polymorphisms

Scientific Reports ◽

10.1038/s41598-021-85780-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mohammad Al-Forkan ◽

Fahmida Binta Wali ◽

Laila Khaleda ◽

Md. Jibran Alam ◽

Rahee Hasan Chowdhury ◽

...

Keyword(s):

Heart Surgery ◽

Cardiac Tissue ◽

Tissue Injury ◽

Open Heart Surgery ◽

Inorganic Arsenic ◽

Vital Role ◽

Nucleotide Polymorphisms ◽

Cross Sectional ◽

Adjusted Analysis ◽

Diabetes Status

AbstractInorganic arsenic (iAs) exposure has been reported to have an impact on cardiovascular diseases (CVD). However, there is not much known about the cardiac tissue injury of CVD patients in relation to iAs exposure and potential role of single nucleotide polymorphisms (SNPs) of genes related to iAs metabolism, oxidative stress, endothelial dysfunction and inflammation which may play important roles in such CVD cases. In this dual center cross-sectional study, based on the exclusion and inclusion criteria, we have recruited 50 patients out of 270, who came from known arsenic-affected and- unaffected areas of mainly Chittagong, Dhaka and Rajshahi divisions of Bangladesh and underwent open-heart surgery at the selected centers during July 2017 to June 2018. We found that the patients from arsenic affected areas contained significantly higher average iAs concentrations in their urine (6.72 ± 0.54 ppb, P = 0.028), nail (529.29 ± 38.76 ppb, P < 0.05) and cardiac tissue (4.83 ± 0.50 ppb, P < 0.05) samples. Patients’ age, sex, BMI, hypertension and diabetes status adjusted analysis showed that patients from arsenic-affected areas had significantly higher iAs concentration in cardiac tissue (2.854, 95%CI 1.017–8.012, P = 0.046) reflecting higher cardiac tissue injury among them (1.831, 95%CI 1.032–3.249, P = 0.039), which in turn allowed the analysis to assume that the iAs exposure have played a vital role in patients’ disease condition. Adjusted analysis showed significant association between urinary iAs concentration with AA (P = 0.012) and AG (P = 0.034) genotypes and cardiac iAs concentration with AA (P = 0.017) genotype of AS3MT rs10748835. The AG genotype of AS3MT rs10748835 (13.333 95%CI 1.280–138.845, P = 0.013), AA genotype of NOS3 rs3918181 (25.333 95%CI 2.065–310.757, P = 0.002), GG genotype of ICAM1 rs281432 (12.000 95%CI 1.325–108.674, P = 0.010) and AA genotype of SOD2 rs2758331 (13.333 95%CI 1.280–138.845, P = 0.013) were found significantly associated with CVD patients from arsenic-affected areas. Again, adjusted analysis showed significant association of AA genotype of AS3MT rs10748835 with CVD patients from arsenic affected areas. In comparison to the reference genotypes of the selected SNPs, AA of AS3MT 10748835, AG of NOS3 rs3918181 and AC of rs3918188, GG of ICAM1 rs281432, TT of VCAM1 rs3176867, AA of SOD2 rs2758331 and GT of APOE rs405509 significantly increased odds of cardiac tissue injury of CVD patients from arsenic affected areas. The results showed that the selected SNPs played a susceptibility role towards cardiac tissue iAs concentration and injury among CVD patients from iAs affected areas.

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Inter‐ and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic

Advanced Science ◽

10.1002/advs.202002715 ◽

2021 ◽

Vol 8 (7) ◽

pp. 2002715

Author(s):

Yingyun Gong ◽

Yanfeng Xue ◽

Xin Li ◽

Zhao Zhang ◽

Wenjun Zhou ◽

...

Keyword(s):

Inorganic Arsenic ◽

Transgenerational Effects ◽

Paternal Exposure

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ANN-Based Integrated Risk Ranking Approach: A Case Study of Contaminants of Emerging Concern of Fish and Seafood in Europe

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18041598 ◽

2021 ◽

Vol 18 (4) ◽

pp. 1598

Author(s):

Vikas Kumar ◽

Saurav Kumar

Keyword(s):

Food Safety ◽

Flame Retardants ◽

Toxic Elements ◽

Hazard Index ◽

Inorganic Arsenic ◽

Contaminants Of Emerging Concern ◽

Major Pathway ◽

Screening Programs ◽

Integrated Risk ◽

Emerging Compounds

Seafood, one of the most important food commodities consumed worldwide, is considered a high-quality, healthy, and safe food option. However, marine ecosystems are the ultimate destination for a large group of chemicals, including contaminants of emerging concern, and seafood consumption is a major pathway of human exposure. With growing awareness of food safety and food quality, and increased demand for information on the risk of contaminants of emerging concern, there is a need to assess food safety issues related to harmful contaminants in seafood and ensure the safety of marine food resources. In this study, the risks of emerging compounds (endocrine disruptors, brominated flame retardants, pharmaceuticals and personal care products, and toxic elements) in fish and seafood were analyzed according to their PBT (persistence, bioaccumulation, toxicity) properties as well as in terms of their concentration levels in seafood. A hazard index (HI) was estimated for each compound by applying an artificial neural network (ANN) approach known as Self-Organizing-Maps. Subsequently, an integrated risk rank (IRI) was developed considering the values of HI and the concentrations of emerging compounds in seafood species gathered from the scientific literature. Current results identified HHCB, MeHg, NP, AHTN and PBDE209 as the top five highest ranked compounds present in seafood, according to the 50th percentile (mean) of the IRI. However, this ranking slightly changed when taking into account the 99th percentile of the IRI, showing toxic elements, methylmercury and inorganic arsenic, as having the highest risk. The outcome of this study identified the priority contaminants and should help in regulatory decision-making and scientific panels to design screening programs as well as to take the appropriate safety measures.

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Concentration of folic acid (FA) in serum of Japanese pregnant women

Reviews on Environmental Health ◽

10.1515/reveh-2020-0014 ◽

2020 ◽

Vol 35 (3) ◽

pp. 277-280

Author(s):

Nathan Mise ◽

Mayumi Ohtsu ◽

Akihiko Ikegami ◽

Yoko Hosoi ◽

Yoshihiko Nakagi ◽

...

Keyword(s):

Folic Acid ◽

Pregnant Women ◽

Epigenetic Modification ◽

Large Fraction ◽

Body Burden ◽

Inorganic Arsenic ◽

Health Concern ◽

Japanese Children ◽

Cross Sectional ◽

Japanese Pregnant Women

AbstractObjectivesExposure to inorganic arsenic (iAs) is a world-wide health concern. We reported that Japanese children and pregnant women are exposed to moderate levels of iAs through food. Reducing iAs contamination from foods of high iAs is an important issue unique in Japan. Integrated iAs is methylated to less toxic organic forms, and S-adenosyl-L-methyonine (SAM), a common methyl-donor of DNA and histones, is utilized in this process. Chronic consumption of SAM by iAs metabolism due to exposure to iAs might alter the epigenetic modification of genome. The SAM biosynthesis pathway is dependent on folate cycle, and it is possible that ingestion of sufficient folic acid (FA) is protective to iAs induced toxicity.MethodsIn the course of our cross-sectional body burden analyses of Pb and iAs in Japanese children and pregnant women, termed “PbAs study”, FA concentration in serum of 104 pregnant women was measured.ResultsMean (±SEM) of serum FA concentration was 15.8 ± 1.3 (ng/mL). There are significant number of people showing very high FA (>30 ng/ mL), and large fraction of them were taking supplements daily.ConclusionsThese results suggested that level of FA ingestion of Japanese pregnant women is high for supporting normal fetal development.

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