Biocompatibility and drug delivery efficiency of PEG-b-PCL/hydroxyapatite bilayer coatings on Nitinol superelastic alloy

2020 ◽  
Vol 46 (8) ◽  
pp. 12711-12717
Author(s):  
M.R. Etminanfar ◽  
S.O.R. Sheykholeslami ◽  
V. Khalili ◽  
S. Mahdavi
Keyword(s):  
Drug Delivery ◽  
Delivery Efficiency ◽  
Bilayer Coatings

Influence of Divalent Cation on Morphology and Drug Delivery Efficiency of Mixed Polymer Nanoparticles

2018 ◽  
Vol 15 (5) ◽  
pp. 652-657 ◽  
Author(s):  
Ramachandran Deepika ◽  
Koyeli Girigoswami ◽  
Ramachandran Murugesan ◽  
Agnishwar Girigoswami
Keyword(s):  
Drug Delivery ◽  
Divalent Cation ◽  
Polymer Nanoparticles ◽  
Delivery Efficiency

scholarly journals Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 192 ◽  
Author(s):  
Chang ◽  
Moon ◽  
Oh ◽  
Yoon ◽  
Gu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aerosol Particles ◽  
Clinical Validation ◽  
Output Rate ◽  
Medication Delivery ◽  
Jet Nebulizer ◽  
Jet Nebulizers ◽  
Effective Medication ◽  
Delivery Efficiency ◽  
Better Than

Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by ELISA. The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage.

In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers

2018 ◽  
Vol 47 ◽  
pp. 62-66 ◽  
Author(s):  
Yuko Okamoto ◽  
Kazuaki Taguchi ◽  
Mina Sakuragi ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Hydrophobic Drug ◽  
Delivery Efficiency

scholarly journals Albumin-based nanosystems in medicine

2018 ◽  
Vol 72 ◽  
pp. 1004-1017
Author(s):  
Bogusława Konopska ◽  
Krzysztof Gołąb ◽  
Katarzyna Juszczyńska ◽  
Jakub Gburek
Keyword(s):  
Drug Delivery ◽  
The United States ◽  
Delivery Systems ◽  
Anti Cancer ◽  
United States Food ◽  
Poorly Soluble ◽  
States Food ◽  
The Common ◽  
Low Cytotoxicity ◽  
Delivery Efficiency

Proteins are natural and safe substitutes of the synthetic polymers for the development of drug delivery systems (DDS). Few of proteins have been approved for drug delivery purposes by the United States Food and Drug Administration (FDA). Among them, albumin is the most explored carrier for synthesis of therapeutic nanoparticles. Its usefulness was determined by the common accessibility, biocompatibility and the feasibility of accumulation in tissues with increased metabolism. Albumin with its properties is particularly attractive carrier for anti-arthritis and anti-cancer drugs. It is mainly used to design delivery systems for poorly soluble substances with low permeability through biological membranes. The albumin nanoparticles are characterized by favourable pharmacokinetics, high drug delivery efficiency and low cytotoxicity. In addition, they are biodegradable, relatively easy to prepare and non-immunogenic. Interest in the exploration of clinical applications of albumin-based drug delivery carriers, especially for those at the nanoscale, has increased in recent years. A lot of research have been done to design multifunctional theranostic nanosystems that could be used for both imaging and cancer therapy. This article aims at providing an overview of already commercialized and just emerging applications of albumin-based nanosystems as drug delivery carriers.

Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non‐renal Clearable Nanocarriers

2019 ◽  
Vol 131 (35) ◽  
pp. 12204-12208
Author(s):  
Chuanqi Peng ◽  
Mengxiao Yu ◽  
Jer‐Tsong Hsieh ◽  
Payal Kapur ◽  
Jie Zheng
Keyword(s):  
Drug Delivery ◽  
Vascular Permeability ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Efficiency

scholarly journals Intercellular Bioimaging and Biodistribution of Gold Nanoparticle-Loaded Macrophages for Targeted Drug Delivery

Electronics ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1105
Author(s):  
Sehwan Kim ◽  
Sung Hun Kang ◽  
Soo Hwan Byun ◽  
Hye-Jin Kim ◽  
In-Kyu Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticle ◽  
Fluorescence Imaging ◽  
Inductively Coupled Plasma ◽  
Ex Vivo ◽  
Imaging Techniques ◽  
Target Delivery ◽  
Icp Ms ◽  
Vis Spectroscopy ◽  
Delivery Efficiency

In order to effectively apply nanoparticles to clinical use, macrophages have been used as vehicles to deliver genes, drugs or nanomaterials into tumors. In this study, the effectiveness of macrophage as a drug delivery system was validated by biodistribution imaging modalities at intercellular and ex vivo levels. We focused on biodistribution imaging, namely, the characterization of the gold nanoparticle-loaded macrophages using intracellular holotomography and target delivery efficiency analysis using ex vivo fluorescence imaging techniques. In more detail, gold nanoparticles (AuNPs) were prepared with trisodium citrate method and loaded into macrophage cells (RAW 264.7). First, AuNPs loading into macrophages was confirmed using the conventional ultraviolet-visible (UV-VIS) spectroscopy and inductively coupled plasma-mass spectrometry (ICP-MS). Then, the holotomographic imaging was employed to characterize the intracellular biodistribution of the AuNPs-loaded macrophages. The efficacy of target delivery of the well AuNPs uptake macrophages was studied in a mouse model, established via lipopolysaccharide (LPS)-induced inflammation. The fluorescent images and the ex vivo ICP-MS evaluated the delivery efficiency of the AuNPs-loaded macrophages. Results revealed that the holotomographic imaging techniques can be promising modalities to understand intracellular biodistribution and ex vivo fluorescence imaging can be useful to validate the target delivery efficacy of the AuNPs-loaded macrophages.

Length effect of stimuli-responsive block copolymer prodrug filomicelles on drug delivery efficiency

2020 ◽  
Vol 318 ◽  
pp. 67-77 ◽  
Author(s):  
Wendong Ke ◽  
Nannan Lu ◽  
Abd Al-Wali Mohammed M. Japir ◽  
Qinghao Zhou ◽  
Longchang Xi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Stimuli Responsive ◽  
Length Effect ◽  
Delivery Efficiency

A Resveratrol-Loaded Poly(2-hydroxyethyl methacrylate)-Chitosan Based Nanotherapeutic: Characterization and In Vitro Cytotoxicity Against Prostate Cancer

2021 ◽  
Vol 21 (4) ◽  
pp. 2090-2098
Author(s):  
Erdal Eroglu
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Human Prostate ◽  
Great Promise ◽  
Hydroxyethyl Methacrylate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Delivery Efficiency

The delivery of therapeutic molecules such as drugs, nucleic acids, or other active molecules into the target tissue and cells is limited because of biological and cellular barriers. Recently, many efforts are being made to bypass these barriers using nanosized drug delivery vehicles. For the targeted transfer of anticancer agents into the cancer tissue with higher efficiency and lower cellular toxicity, synthesis of nano-scale smart materials hold great promise due to the enhanced permeability and retention capability. Encapsulation of natural anticancer compounds such as resveratrol displaying low water-solubility and poor chemical stability into nanomaterials are intensely being studied to achieve the enhanced anticancer activity. The aim of this study is to investigate the drug delivery efficiency of the poly(2-hydroxyethyl methacrylate) (pHEMA)-chitosan nanoparticles (PCNPs) against PC-3 human prostate cancer cells In Vitro. To achieve this aim, resveratrol (RES), one of the widely known natural anticancer agent, is encapsulated into pHEMA core and pHEMARES nanospheres were coated with a cationic polymer, chitosan. Then, developed PCNPs-RES complexes were characterized using fourier transformed infrared (FTIR) spectroscopy, ultraviolet (UV) visible spectroscopy, scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential and atomic force microscopy (AFM) analyses. The characterization studies revealed the synthesis of PCNPs nanoparticles and the entrapment of RES into PCNPs. Also, the cytotoxicity and drug delivery efficiency of PCNPs-RES complexes were tested in human prostate cancer cells, PC-3, In Vitro. As a consequence, PCNPs was shown to be a promising candidate as a new generation nanotherapeutic against prostate cancer In Vitro.

A New Approach for β-Cyclodextrin Conjugated Drug Delivery System in Cancer Therapy

2021 ◽  
Vol 18 ◽  
Author(s):  
Teng Meng Sheng ◽  
Palanirajan Vijayaraj Kumar
Keyword(s):  
Drug Delivery ◽  
Aqueous Solubility ◽  
Optimization Techniques ◽  
Cancer Treatments ◽  
New Approach ◽  
Anti Cancer ◽  
Cancer Multiple ◽  
Derivatives Of ◽  
Delivery Efficiency ◽  
Biopharmaceutics Classification

: Natural cyclodextrins (CDs) are macrocyclic starch molecules discovered a decade ago, in which α-, β-, and γ-CD were commonly used. They originally acted as pharmaceutical excipients to enhance the aqueous solubility and alter the physicochemical properties of drugs that fall under class II and IV categories according to the Biopharmaceutics Classification System (BPS). The industrial significance of CDs became apparent during the 1970s as scientists started to discover more of CD’s potential in chemical modifications and the formation of inclusion complexes. CDs can help in masking and prolonging the half-life of drugs used in cancer. Multiple optimization techniques were discovered to prepare the derivatives of CDs and increase their complexation and drug delivery efficiency. In recent years, due to the advancement of nanotechnology in pharmaceutical sectors, there has been growing interest in CDs. This review mainly focuses on the formulation of cyclodextrin conjugated nanocarriers using graphenes, carbon nanotubes, nanosponges, hydrogels, dendrimers, and polymers to achieve drug-release characteristics specific to cells. These approaches benefit the discovery of novel anti-cancer treatments, solubilization of new drug compounds, and cell specific drug delivery properties. Due to these unique properties of CDs, they are essential in achieving and enhancing tumor-specific cancer treatment.

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