High resolution separations of charge variants and disulfide isomers of monoclonal antibodies and antibody drug conjugates using ultra-high voltage capillary electrophoresis with high electric field strength

2017 ◽  
Vol 1523 ◽  
pp. 72-79 ◽  
Author(s):  
W. Hampton Henley ◽  
Yan He ◽  
J. Scott Mellors ◽  
Nicholas G. Batz ◽  
J. Michael Ramsey ◽  
...  
2019 ◽  
Vol 6 (2) ◽  
pp. 111-114
Author(s):  
R. Kornev ◽  
P. Sennikov ◽  
V. Nazarov ◽  
A. Kut'in ◽  
A. Plekhovich

A contracted RF (40.68 MHz) arc discharge of atmospheric pressure, stabilized between two rod electrodes, was used to obtain trichlorosilane by the reaction of hydrogen reduction of silicon tetrachloride (SiCl<sub>4</sub>). In model mixtures of macro-composition in the ratio H<sub>2</sub>/SiCl<sub>4</sub>/CCl<sub>4</sub>=10/1/1, it was shown that C and SiC are the main solid-phase product which are deposited on the surface of electrodes in the form of dendrides. The temperature of the ends of the electrodes determined using emission thermometry is 1600 K. The thermodynamic analysis of H<sub>2</sub>+SiCl<sub>4</sub>+CCl<sub>4</sub> system confirms that the formation of C and SiC occurs in the temperature range of 1600 K. The deposition of solid-phase products occurs on the electrodes in the zone of high electric field strength.


1980 ◽  
Vol 35 (3) ◽  
pp. 293-301
Author(s):  
G. Böhm

Abstract A resonant coupling mechanism is presented which leads to nearly full absorption of an electromagnetic wave in an overdense plasma column. In the resonance case a strong enhancement of the electric field strength within the plasma is found. Under certain conditions this high electric field strength causes parametric excitation of plasma waves in the underdense edges of the discharge. It turned out that the occurance of this decay process is mainly determined by the density gradients in the plasma.


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