Association of bovine respiratory disease with clinical status and acute phase proteins in calves

The aim of this study was to correlate the serum levels of acute phase proteins (APPs) and cytokines in response to treatment by various antimicrobial agents in feedlots calves (FL) naturally infected with Mannheimia haemolytica (M. haemolytica) and Histophilus somni (H. somni). 840 feedlot calves in one farm in Al-Kharg region, Saudi Arabia were clinically examined for the presence of respiratory disease manifestations. The infection was confirmed using nasopharyngeal swabs. Blood samples from diseased animals were collected before and after (7 days) treatment for biochemical analysis of serum amyloid A (SAA), haptoglobin (HP) and cytokines tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin-1 β (IL1β), and interleukin-8 (IL-8). FL that were positive for M. haemolytica and/or H. somni (n=69) received treatment with one antibiotic, including tulathromycin (Tula; n=26 cases), florfenicol (FFC; n=19), tilmicosin (Tm; n=13), or ceftiofur (CEF; n=11) and one non-steroidal anti-inflammatory drug (Flunixin meglumine (FM; n=43) or phenylbutazone (PBZ; n= 26). We demonstrated the selective potent inhibitory effect of the administrated anti-inflammatory agents either FM or PBZ on the production of APPs and pro-inflammatory cytokines in FL infected with bovine respiratory disease (BRD). Our findings showed the antibacterial efficacy of FFC and Tm for the treatment of infected FL when administrated with either FM or PBZ. However, Tula was preferable to administrate in combination with FM for the treatment of FL with respiratory manifestations. Importantly, monitoring the sera level of Hp, IL-1β, and interleukin-8 (IL-8) in feedlots treated with either FM combined with Tula, FFC, or Tm or PBZ combined with FFC, and Tm has been effective in predicting the disease prognosis

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Potential diagnostic methods and nutritional changes to combat bovine respiratory disease in receiving cattle

10.32469/10355/63531 ◽

2017 ◽

Author(s):

◽

Cooper Daniel Martin

Keyword(s):

Respiratory Disease ◽

Feed Efficiency ◽

Acute Phase Proteins ◽

Animal Health ◽

Bovine Respiratory Disease ◽

Blood Chemistry ◽

Diagnostic Methods ◽

Beef Industry ◽

Healthy Cattle ◽

Cattle Health

Bovine respiratory disease (BRD) accounts for up to 70 percent of health disruptions and $500 million in associated medical costs and production losses, thus receiving considerable attention from cattle health personnel in production and research alike. Experiments were conducted in 2 studies to investigate aspects of nutrition and animal health in receiving cattle. Blood chemistry and immune components of sick and healthy cattle, along with feed intake, growth, and feed efficiency were evaluated for methods potentially useful in BRD diagnosis or offsetting performance losses. Intake, blood chemistry analysis, and immune proteins known as acute phase proteins provided patterns with possible complementarity for more accurate objective BRD diagnosis. Feed efficiency was improved by supplementing amino acids to exceed nutrient requirements. Utilizing these findings could provide incremental improvements in the current stalemate against BRD, improving both beef industry profitability and animal welfare.

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Serum haptoglobin as an indicator of the acute phase response in bovine respiratory disease

Veterinary Immunology and Immunopathology ◽

10.1016/0165-2427(95)05520-7 ◽

1996 ◽

Vol 51 (3-4) ◽

pp. 277-292 ◽

Cited By ~ 96

Author(s):

Dale L. Godson ◽

Manuel Campos ◽

Samuel K. Attah-Poku ◽

Mark J. Redmond ◽

Daphne M. Cordeiro ◽

...

Keyword(s):

Respiratory Disease ◽

Acute Phase ◽

Acute Phase Response ◽

Bovine Respiratory Disease ◽

Phase Response ◽

Serum Haptoglobin

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Acute phase proteins in naturally occurring respiratory disease of feedlot cattle

Veterinary Immunology and Immunopathology ◽

10.1016/j.vetimm.2014.12.006 ◽

2015 ◽

Vol 163 (3-4) ◽

pp. 221-226 ◽

Cited By ~ 10

Author(s):

Ignacio Idoate ◽

Brian Vander Ley ◽

Loren Schultz ◽

Meera Heller

Keyword(s):

Respiratory Disease ◽

Acute Phase ◽

Acute Phase Proteins ◽

Feedlot Cattle ◽

Naturally Occurring

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A COMPARATIVE STUDY ON SELECTED ACUTE PHASE PROTEINS (APPS) AND IMMUNOGLOBULINS IN BUFFALO AND BOVINE CALVES WITH RESPIRATORY DISEASE

Mansoura Veterinary Medical Journal ◽

10.21608/mvmj.2016.129744 ◽

2016 ◽

Vol 17 (2) ◽

pp. 1-10

Author(s):

Mohamed Youssef ◽

Sabry El-khodery ◽

Mohamed Abdo

Keyword(s):

Comparative Study ◽

Respiratory Disease ◽

Acute Phase ◽

Acute Phase Proteins

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Acute phase proteins in naturally occurring respiratory disease of feedlot cattle : a novel approach to diagnosis||Acute phase proteins in naturally occurring respiratory disease of feedlot cattle : a novel approach to diagnosis

10.32469/10355/44425 ◽

2014 ◽

Author(s):

Ignacio Idoate

Keyword(s):

Respiratory Disease ◽

Acute Phase ◽

Acute Phase Proteins ◽

Feedlot Cattle ◽

Naturally Occurring ◽

Novel Approach

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Effects of transportation on cattle health and production: a review

Animal Health Research Reviews ◽

10.1017/s1466252318000075 ◽

2018 ◽

Vol 19 (2) ◽

pp. 142-154 ◽

Cited By ~ 13

Author(s):

N. K. Van Engen ◽

J. F. Coetzee

Keyword(s):

Respiratory Disease ◽

Acute Phase Proteins ◽

Bovine Respiratory Disease ◽

Mitigation Strategies ◽

Negative Effects ◽

Starting Point ◽

Before And After ◽

Physiologic Parameters ◽

Cattle Health ◽

Physiologic Responses

AbstractThe goal of this review is to present a concise and critical assessment of the literature related to physiologic responses in cattle that are subjected to transportation. Over two-thirds of US cattle are transported. Understanding trends in circulating physiologic parameters is an important part of mitigating the negative effects of transportation. For the producer, linking these effects after transportation to morbidity outcomes within the first 45 days on feed (i.e. especially development of bovine respiratory disease) is critical. Physiologic parameters in circulation are of primary importance and may have value for prediction of bovine respiratory disease on arrival and for the understanding of disease pathogenesis. The results of our literature survey indicated that post-transportation immune function, increased acute phase proteins, glucocorticoids, and inflammation are a pivotal starting point for understanding disease. These potential biomarkers may have utility in identifying disease for targeted therapeutics so that traditional protocols that rely heavily on metaphylaxis can be avoided. Additional research is needed to develop strategies for physiological marker identification, treatment methods, or predictive behaviors to prevent respiratory disease before and after transport. This review examines the significant deleterious effects of transportation handling and stress, and current immune system translation and non-antimicrobial mitigation strategies.

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