Combined Hormonal Contraceptive Use and Risk of Breast Cancer in a Population of Women With a Family History

2018 ◽  
Vol 18 (1) ◽  
pp. e15-e24 ◽  
Author(s):  
Giovanni Grandi ◽  
Angela Toss ◽  
Angelo Cagnacci ◽  
Luigi Marcheselli ◽  
Silvia Pavesi ◽  
...  
Author(s):  
Maria I. Rodriguez ◽  
Menolly Kaufman ◽  
Brynna Manibusan ◽  
Lorinda Anderson ◽  
K. John McConnell

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Rosângela C. Rodrigues ◽  
Flávia Schechtman Belham ◽  
Ana Garcia ◽  
Corina Satler ◽  
Carlos Tomaz ◽  
...  

This study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female S. libidinosus from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. The physiological parameters were accessed by means of 13 blood samples from each female, whereas three were gathered during the baseline and 10 samples were collected during the treatment phase. The results showed that the contraceptive use provoked changes in hematological coagulation factors such as an increase in the amount of platelets (p=0.039) and a reduction in both prothrombin (p<0.001) and thromboplastin coagulation time (p<0.001). These results are similar to what has been observed in human patients; thus, it is concluded that S. libidinosus can be successfully used in studies about the physiological impact of hormonal contraceptives.


Obesity ◽  
2020 ◽  
Vol 28 (6) ◽  
pp. 1040-1049
Author(s):  
Ann E. Caldwell ◽  
Adnin Zaman ◽  
Danielle M. Ostendorf ◽  
Zhaoxing Pan ◽  
Bryan B. Swanson ◽  
...  

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 165-170
Author(s):  
Aadhyyanth R Allu ◽  
Jayaganesh ◽  
Senthil Kumar A C

Breast cancer is a very common malignancy diagnosed in India and is the most common cancer in women in India. The morbidity and mortality burden of malignancy in India ranks one of the highest in the world. India has a network of cancer registries, a process which has expanded since the 1960s and has new initiatives such as cancer atlas and online software programmes. The  burden  of  breast  cancer  is on  the  rise  in  both  developed  and  developing  countries. The objectives were to identify and study the risk factors for breast cancer among women attending Saveetha Medical College and Hospital, Chennai and to study the association between risk factors and breast cancer. The case control study was conducted on 110 cases and 110 controls. A semi-structured questionnaire was used to collect information. Statistical Analysis was done using MS Excel 2007 and Chi Square test was also used. Of the parameters studied, residence, family history, parity, duration of breast feeding and oral contraceptive use were found to be associated with breast cancer and were statistically significant (p<0.05). The findings suggest that positive family history, nulliparity, duration of breast feeding and OCP use may have an impact on breast cancer in Indian women. Hence screening and creation of awareness may help in decreasing mortality.


Author(s):  
Ika Avrilina Haryono ◽  
Adriana Palimbo ◽  
Difa Okti Al Kautsar

ABSTRAKLatar Belakang : Kanker payudara merupakan salah satu penyebab kematian utama pada wanita di dunia. Sejauh ini, kanker payudara paling sering diderita oleh wanita dengan perkiraan 43,3% juta kasus kanker baru yang didiagnosis pada tahun 2012. Angka kejadian kanker payudara bervariasi secara global dimana terjadi peningkatan insiden di negara berkembang tetapi cenderung menurun dinegara maju, dengan kasus pada negara berkembang (883.000 kasus) negara maju (794.000 kasus). Tujuan: Menganalisis faktor resiko yang berhubungan dengan kejadian kanker payudara meliputi faktor umur, umur pertama menstruasi, menopause, umur pertama kali menikah, riwayat penggunaan kontrasepsi hormonal, riwayat pemberian ASI, da riwayat kanker payudara pada keluarga.Metode: Penelitian ini adalah penelitian kuantitatif menggunakan metode survey analitik dengan rancangan cross sectional. Populasi dalam penelitian ini berjumlah 760 orang dengan sampel 88 orang. Teknik pengumpulan data primer, teknik analisa data yang digunakan adalah uji chi square dan uji regresi berganda.Hasil: Hasil Uji Chi Square menunjukan bahwa terdapat hubungan signifikan antara umur (p=0.000) dan penggunaan kontrasepsi hormonal (p=0.002) dengan hasil uji regresi berganda (p-value0.05) menunjukan bahwa tidak ada pengaruh faktor risiko terhadap kejadian kanker payudara.Simpulan: Ada hubungan antara umur dan riwayat penggunaan kontrasepsi hormonal dengan kejadian kanker payudara. Tidak ada pengaruh faktor resiko terhadap kejadian kanker payudara. Kata Kunci: kanker payudara, riwayat penggunaan kontrasepsi hormonal, umur Risk Factors Related to Breast Cancer IncidenceIn the Edelweis Room of Ulin Hospital Banjarmasin AbstractBackground: Breast cancer is one of the leading causes of death in women in the world. So far, breast cancer most often affects women with an estimated 43.3% of new cancer cases diagnosed in 2012. The incidence of breast cancer varies globally where there is an increase in incidents in developing countries but tends to decrease in developed countries, with cases in the country developing (883,000 cases) developed countries (794,000 cases).Objective: Analyzing risk factors associated with breast cancer events include age, age at first menstruation, menopause, age at first marriage, history of use of hormonal contraception, history of breastfeeding, and history of breast cancer in the family.Method: This study is a quantitative study using analytical survey method with cross sectional design. The population in this study amounted to 760 people with a sample of 88 people. Primary data collection techniques, data analysis techniques used are chi square test and multiple regression test.Results: Chi Square test results showed that there was a significant relationship between age (p = 0,000) and hormonal contraceptive use (p = 0.002) with the results of multiple regression tests (p-value 0.05) indicating that there was no effect of risk factors on breast cancer incidence.Conclusion: There is a relationship between age and history of hormonal contraceptive use with the incidence of breast cancer. There is no effect of risk factors on the incidence of breast cancer. Keywords: breast cancer, history of hormonal contraceptive use, age


2021 ◽  
Vol 53 (04) ◽  
pp. 175-178

Ostroot MK et al. Breast cancer recurrence risk after hormonal contraceptive use in survivors of reproductive age. Eur J Obstet Gynecol Reprod Biol 2021; 258: 174–178. doi: 10.1016/j.ejogrb.2020.12.035


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