Correlation of folate, vitamin B12 and homocysteine plasma levels with depression in an elderly Greek population

2007 ◽  
Vol 40 (9-10) ◽  
pp. 604-608 ◽  
Author(s):  
Nikolaos Dimopoulos ◽  
Christina Piperi ◽  
Aristea Salonicioti ◽  
Vassiliki Psarra ◽  
Flerri Gazi ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Plasma Levels ◽  
Greek Population

Hyperhomocysteinaemia, low folate concentrations and MTHFR C677T mutation in abdominal aortic aneurysm

VASA ◽  
2014 ◽  
Vol 43 (3) ◽  
pp. 181-188 ◽  
Author(s):  
Hui Cao ◽  
Xinhua Hu ◽  
Qiang Zhang ◽  
Jun Li ◽  
Bing Liu ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Folic Acid ◽  
Aortic Aneurysm ◽  
Vitamin B12 ◽  
Gene Mutation ◽  
Plasma Levels ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Abdominal Aortic ◽  
C677t Mutation

Background: Homocysteine (Hcy) has been implicated in abdominal aortic aneurysm (AAA). However, the association of Hcy, vitamin B12, and folate in patients with AAA has not been studied in China. This study was conducted with the aim to evaluate the relationship of vitamin B12, folic acid, and Hcy levels in AAA. Patients and methods: 463 patients who had AAA were included in this study. 463 control subjects were age- and sex-matched with the patients. In all of the subjects, we evaluated total plasma levels Hcy, vitamin B12, folic acid and the distribution of the C677T methylenetetrahydrofolate reductase (MTHFR) gene mutation. Results: The mean plasma Hcy levels were significantly higher in patients with AAA compared with controls (18.37 ± 6.97 vs. 12.89 ± 4.08 μmol/L, P < 0.001). The frequency of homozygous (TT) genotype in MTHFR C677T mutation was significantly higher in patients with AAA than that in control subjects (19.4 % vs. 11.9 %, P = 0.002). The fasting Hcy correlated negatively with folate (A r = - 0.311, P < 0.01; Control: r = - 0.348, P < 0.01). The aneurysm size was significantly greater (P < 0.001) in patients with hyperhomocysteinemia than that in patients with normal Hcy plasma levels. The size of the AAA had a linear correlation with the plasma Hcy level (r = 0.286; P< 0.001). Conclusions: Serum folate deficiency and hyperhomocysteinemia were associated with an increased risk of AAA in Northeast China. The homozygous (TT) genotype of MTHFR gene mutation may be a crucial hereditary risk factor in AAA.

scholarly journals Increased plasma levels of 8-Iso-PGF2α in an elderly Greek population with cognitive impairment

2008 ◽  
Vol 7 (S1) ◽  
Author(s):  
Nikolaos Dimopoulos ◽  
Vassiliki Psarra ◽  
Charalambos Mitsonis ◽  
Christina Piperi ◽  
Anastasios Kalofoutis
Keyword(s):  
Cognitive Impairment ◽  
Plasma Levels ◽  
Greek Population

scholarly journals Erythrocyte Vitamin B12 Activity in Health, Polycythemia, and in Deficiency of Vitamin B12 and Folate

Blood ◽  
1970 ◽  
Vol 35 (1) ◽  
pp. 73-82 ◽  
Author(s):  
A. OMER ◽  
N. D. C. FINLAYSON ◽  
D. J. C. SHEARMAN ◽  
R. R. SAMSON ◽  
R. H. GIRDWOOD
Keyword(s):  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Plasma Levels ◽  
Normal Subjects ◽  
Folate Deficiency ◽  
Mean Value ◽  
Normal Range ◽  
The Mean ◽  
Secondary Polycythemia

Abstract A method for the estimation of vitamin B12 in erythrocytes using E. gracilis is described. In 29 normal subjects the mean value was 158 pg./ml. (S.D. 31 pg.) packed cells. Five of 14 patients with untreated primary polycythemia had very low erythrocyte vitamin B12 levels, and in the group as a whole the value was significantly less than normal. In eight patients with secondary polycythemia the erythrocyte vitamin B12 did not differ from normal, though two patients had values below the normal range. In 19 cases of pernicious anemia the mean erythrocyte vitamin B12 level was 53 pg./ml. (S.D. 32 pg.) packed cells which was significantly reduced. There was no constant relation between the erythrocyte and plasma levels. In eight cases of folate deficiency the erythrocyte vitamin B12 level was significantly reduced, with a mean value of 95 pg./ml. (S.D. 57 pg.) packed cells.

Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease

2004 ◽  
Vol 42 (9) ◽  
Author(s):  
Mariano Malaguarnera ◽  
Raffaele Ferri ◽  
Rita Bella ◽  
Giovanna Alagona ◽  
Anna Carnemolla ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Nutritional Status ◽  
Vitamin B12 ◽  
Vascular Dementia ◽  
Plasma Levels ◽  
Vitamin B ◽  
Elevated Plasma

AbstractThe association between elevated plasma levels of homocysteine (Hcy) and nutritional status has been shown in Alzheimer disease (AD) patients and also in vascular dementia (VaD). Moreover, a previous study provided evidence that the relation between a high Hcy level and low vitamin BIncreased levels of Hcy associated with low vitamin B

scholarly journals Successful Treatment of Isotretinoin Induced Musculoskeletal Pain by Vitamin B12 and Folic Acid

2019 ◽  
Vol 7 (21) ◽  
pp. 3726-3727
Author(s):  
Amir Feily
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Musculoskeletal Pain ◽  
Successful Treatment ◽  
Plasma Levels ◽  
Enzymatic Reactions ◽  
Lower Plasma ◽  
Case Presentation

BACKGROUND: Daily supplementation with vitamin B12 and folate, which are the cofactors of the enzymatic reactions involved in Hcy metabolism, can lower plasma levels of Hcy and prevent osteoporosis induced by retinoid CASE PRESENTATION: We reported six patients with nodulocystic acne who reported musculoskeletal pain after taking isotretinoin which successfully treated with daily supplementation of folic acid and B12. CONCLUSION: We suggest our colleagues consider these supplements when a patient suffers from musculoskeletal pain following starting isotretinoin and continue the treatment as well. In the end, the authors concluded that robust trials with more patients are needed to establish the efficacy of Vit B12 and folic acid in the treatment of isotretinoin induced musculoskeletal pain.

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