The relationship of long non-coding RNA maternally expressed gene 3 with microRNA-21 and their correlation with acute ischemic stroke risk, disease severity and recurrence risk

2021 ◽  
pp. 106940
Author(s):  
Chunping Liu ◽  
Hua Huang ◽  
Yuan Li ◽  
Haiyan Zhao
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Stroke Risk ◽  
Recurrence Risk ◽  
Non Coding Rna ◽  
Ischemic Stroke Risk ◽  
Relationship Of ◽  
The Relationship ◽  
Long Non Coding Rna ◽  
Maternally Expressed Gene 3

scholarly journals Parathyroid Hormone Levels in the Prediction of Ischemic Stroke Risk

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Güner Çelik ◽  
Ali Doğan ◽  
Şefik Dener ◽  
Şerefnur Öztürk ◽  
Sevsen Kulaksızoğlu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Stroke Risk ◽  
Blood Chemistry ◽  
Dihydroxyvitamin D ◽  
Stroke Risk Factors ◽  
Ischemic Stroke Risk ◽  
Age Range ◽  
The Relationship ◽  
Estimation Models

Objective. It was examined whether PTH and 25-dihydroxyvitamin D (25(OH)D) levels, together or separately, are indicators of the risk of stroke. Materials and Methods. This prospective study was performed at two centers. In the study, 100 patients diagnosed with acute ischemic stroke and 100 control individuals in the same age range were examined. In addition to neurological examination, cranial imaging, extensive routine blood chemistry, PTH, and 25(OH)D levels were evaluated in all cases. Stroke risk factors were determined. Logistic regression was used for statistical analysis. Results. A total of 60 patients and 79 control individuals were included in the study. Different estimation models were designed in order to examine the relationship between PTH and 25(OH)D levels with stroke. According to modeling results, it was determined that the most effective predictor for risk of stroke was 25(OH)D levels, followed by hypertension and PTH levels, respectively. Conclusion. PTH and 25(OH)D levels together can make important contributions to determination of stroke risk, and further investigations are needed to understand this relationship more fully.

Association of collateral status and ischemic core growth in patients with acute ischemic stroke

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011258
Author(s):  
Longting Lin ◽  
Jianhong Yang ◽  
Chushuang Chen ◽  
Huiqiao Tian ◽  
Andrew Bivard ◽  
...  
Keyword(s):  
Growth Rate ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Ct Perfusion ◽  
Study Cohort ◽  
Vessel Occlusion ◽  
Ischemic Core ◽  
Relationship Of ◽  
The Relationship ◽  
Linear Regressions

ObjectiveTo test the hypothesis that acute ischemic patients with poorer collaterals would have faster ischemic core growth, we included 2 cohorts in the study, cohort 1 of 342 patients for derivation and cohort 2 of 414 patients for validation purpose.MethodsAcute ischemic stroke patients with large vessel occlusion were included. Core growth rate was calculated by the following equation: Core growth rate = Acute core volume on CTP/Time from stroke onset to CTP. Collateral status was assessed by the ratio of severe hypoperfusion volume within the hypoperfusion region of CTP. The CTP collateral index was categorized in tertiles; for each tertile, core growth rate was summarized as median and inter-quartile range. Simple linear regressions were then performed to measure the predictive power of CTP collateral index in core growth rate.ResultsFor patients allocated to good collateral on CT perfusion (tertile 1 of collateral index), moderate collateral (tertile 2), and poor collateral (tertile 3), the median core growth rate was 2.93 mL/h (1.10–7.94), 8.65 mL/h (4.53–18.13), and 25.41 mL/h (12.83–45.07) respectively. Increments in the collateral index by 1% resulted in an increase of core growth by 0.57 mL/h (coefficient = 0.57, 95% confidence interval = [0.46, 0.68], p < 0.001). The relationship of core growth and CTP collateral index was validated in cohort 2. An increment in collateral index by 1% resulted in an increase of core growth by 0.59 mL/h (coefficient = 0.59 [0.48–0.71], p < 0.001) in cohort 2.ConclusionCollateral status is a major determinant of ischemic core growth.

scholarly journals The Relationship between Serum Insulin-Like Growth Factor I Levels and Ischemic Stroke Risk

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94845 ◽  
Author(s):  
Xiang Dong ◽  
Geng Chang ◽  
Xiao-Fei Ji ◽  
Ding-Bo Tao ◽  
Ying-Xin Wang
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Stroke Risk ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Ischemic Stroke Risk ◽  
Growth Factor I ◽  
The Relationship

scholarly journals Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nurbanu Gurbuzer ◽  
Eren Gozke ◽  
Zeliha Ayhan Basturk
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Cerebrovascular Risk ◽  
The Mean ◽  
And Gender ◽  
Glutamyl Transferase ◽  
Relationship Of ◽  
The Relationship

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P<0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P<0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.

scholarly journals The implication of circulating long non-coding RNA MALAT1 in diagnosis, disease surveillance and prognosis of acute ischemic stroke

2019 ◽  
Author(s):  
Hongbo Ren ◽  
Feng Wu ◽  
Bin Liu ◽  
Zhi-Yuan Song ◽  
Da-Cheng Qu
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Predictive Value ◽  
Quantitative Polymerase Chain Reaction ◽  
High Expression ◽  
Inflammatory Factor ◽  
Nihss Score ◽  
Non Coding Rna ◽  
Tnf Α ◽  
Long Non Coding Rna

Abstract Background We aimed to investigate predictive value of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lnc-MALAT1) for acute ischemic stroke (AIS) risk, and the association of lnc-MALAT1 expression with disease severity, inflammation as well as recurrence free survival (RFS) in AIS patients.Methods 120 AIS patients and 120 controls were recruited. Venous blood samples from AIS patients (within 24 hours after symptoms onset) and controls (at entry to study) were collected to detect plasma lnc-MALAT1 expression by real-time quantitative polymerase chain reaction. For AIS patients, AIS severity was assessed by NIHSS score; plasma concentrations of inflammation factors (including C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8, IL-10, IL-17 and IL-22) were measure; and RFS was calculated.Results Lnc-MALAT1 expression was decreased in AIS patients compared to controls, and it had a good predictive value for AIS risk (AUC=0.791, 95% CI: 0.735-0.846). For disease condition, lnc-MALAT1 expression negatively correlated with NIHSS score and pro-inflammatory factors expressions (including CRP, TNF-α, IL-6, IL-8 and IL-22), while it positively correlated with anti-inflammatory factor IL-10 expression. Besides, lnc-MALAT1 expression was elevated in AIS complicated with diabetes but numerically reduced in AIS complicated with hepertension. For prognosis, lnc-MALAT1 high expression numerically correlated with longer RFS, but without statistical significance.Conclusion lnc-MALAT1 is downregulated and has a good predictive value of AIS risk, and its high expression correlates with decreased NIHSS score, reduced inflammation, as well as numerically better RFS in AIS patients.

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