Short-term impact of a vegetarian and the nordic diet on metabolic risk factors: a human intervention study in adults with a risk phenotype for cardio metabolic diseases

Context.—The common risk factors for hepatocellular carcinoma (HCC) include persistent viral infection with either hepatitis B or C virus, alcohol abuse, hemochromatosis, and metabolic syndrome. Steatohepatitic (SH) HCC has been recently recognized as a special morphologic variant of HCC associated with metabolic risk factors. Objective.—To assess the SH pattern in HCC cases of various etiologies in Indian patients and to further correlate this morphology with the presence of metabolic risk factors. Design.—A total of 101 cases of HCC with various etiologies in explanted livers from adults were included in the study. Morphologic examination was performed to identify SH lesions within the tumor and in the nontumorous liver parenchyma. Correlation of nontumor and tumor SH morphology with clinically identifiable metabolic risk factors and with non-SH type of HCC was performed. Results.—The SH variant of HCC was identified in 19 livers (18.8%). Most SH-HCC cases were associated with metabolic risk factors such as obesity, diabetes, hypertension, and hyperlipidemias. Comparison of SH-HCC with non–SH-HCC was statistically significant in terms of presence of metabolic risk factors. Conclusions.—Steatohepatitic morphology in HCC is frequent in nonalcoholic fatty liver disease–associated cirrhosis (P = .009) and is significantly associated with metabolic risk factors (P = .03). By recognizing SH pattern, one may predict associated metabolic diseases and determine the prognosis both in pretransplant and posttransplant patients.

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251-OR: Impact of Vegetarian and the Nordic Diet on Glucose Metabolism: A Human Intervention Study

Diabetes ◽

10.2337/db21-251-or ◽

2021 ◽

Vol 70 (Supplement 1) ◽

pp. 251-OR

Author(s):

HANNA HUBER ◽

BIRGIT STOFFEL-WAGNER ◽

MARTIN COENEN ◽

LEONIE WEINHOLD ◽

MATTHIAS SCHMID ◽

...

Keyword(s):

Glucose Metabolism ◽

Intervention Study ◽

Human Intervention ◽

Nordic Diet ◽

Human Intervention Study

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The effects of changes in body mass and subcutaneous fat on the improvement in metabolic risk factors in obese children after short-term weight loss

Metabolism ◽

10.1053/meta.2001.27230 ◽

2001 ◽

Vol 50 (11) ◽

pp. 1323-1329 ◽

Cited By ~ 7

Author(s):

Karl Michael Sudi ◽

Siegfried Gallistl ◽

Martina Tr[ouml ]binger ◽

Doris Payerl ◽

Reingard Aigner ◽

...

Keyword(s):

Risk Factors ◽

Weight Loss ◽

Body Mass ◽

Subcutaneous Fat ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Obese Children ◽

Short Term

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Cardio-metabolic risk factors among patients with tuberculosis attending tuberculosis treatment centers in Nepal

10.21203/rs.3.rs-20468/v1 ◽

2020 ◽

Author(s):

Indra Prasad Poudyal ◽

Pratik Khanal ◽

Shiva Raj Mishra ◽

Milan Malla ◽

Prakash Poudel ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Pulmonary Tuberculosis ◽

Metabolic Diseases ◽

Treatment Guideline ◽

Metabolic Risk Factors ◽

Tuberculosis Treatment ◽

Metabolic Risk Factor ◽

Metabolic Risk ◽

Co Morbidity

Abstract Background The co-morbidity of cardio-metabolic diseases in patients with Tuberculosis adds a significant burden in current health systems in developing countries including Nepal. The main objective of this study was to explore cardio-metabolic risk factors among patients with Tuberculosis. Methods This was a cross-sectional study conducted in 12 tuberculosis centers from eight districts of Nepal between May and July 2017. A total of 238 patients with tuberculosis who visited Tuberculosis centers for Directly Observed Treatment Short-course therapy participated in this study. Interviews with participants were conducted using a structured questionnaire and were supplemented by anthropometric measurements and on site blood glucose tests. Data were analyzed using descriptive and inferential statistics. Results Among 221 study participants, 138 (62.4%) had new smear positive pulmonary tuberculosis, 24 (10.9%) had new smear negative pulmonary tuberculosis and 34 (15.4%) had new extra pulmonary tuberculosis. Overall, 43.1% of the patients with tuberculosis had at least one cardio-metabolic risk factor. The prevalence of at least one cardio-metabolic risk factor was more in male than female (47.8% versus 33.8%). Prevalence of tobacco (18.9% versus 4.8%), and alcohol (12.6% versus 6.5%) use was proportionately higher in male compared to female. The prevalence of hypertension (17% vs. 21%) and obesity (11.9% vs. 12.9%) was lower in male compared to females. Female (AOR=0.47; CI: 0.23-0.94), those from Gandaki Province (AOR=0.32; CI: 0.13-0.79) and literate (AOR=0.49; CI: 0.25-0.96) had reduced risk of cardio-metabolic disease risk factors. Conclusions This study highlights the role of gender and socio-demographic characteristics associated with the risk of cardio-metabolic diseases in patients with Tuberculosis. The findings from this study can guide medical practitioners and policy makers to consider clinical suspicion, diagnosis and treatment. National treatment guideline can benefit by integrating the management of non-communicable diseases in Tuberculosis treatment centers.

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The effect of a short-term hypocaloric diet on liver gene expression and metabolic risk factors in obese women

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2008.06.009 ◽

2009 ◽

Vol 19 (3) ◽

pp. 177-183 ◽

Cited By ~ 13

Author(s):

M. Hietaniemi ◽

M. Jokela ◽

M. Rantala ◽

O. Ukkola ◽

J.T. Vuoristo ◽

...

Keyword(s):

Gene Expression ◽

Risk Factors ◽

Metabolic Risk Factors ◽

Hypocaloric Diet ◽

Metabolic Risk ◽

Obese Women ◽

Short Term ◽

Liver Gene

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Associations of hair cortisol concentrations with cardio-metabolic risk factors in childhood

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab379 ◽

2021 ◽

Author(s):

Florianne O L Vehmeijer ◽

Susana Santos ◽

Yolanda B de Rijke ◽

Erica L T van den Akker ◽

Janine F Felix ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Metabolic Diseases ◽

Standard Deviation Score ◽

Population Based ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Hair Cortisol ◽

Reactive Protein ◽

Biological Stress

Abstract Context Biological stress is related to cardiovascular disease in adults. The associations of stress with cardiovascular and metabolic diseases may originate in childhood. Objective To examine the associations of hair cortisol concentrations at 6 years with cardio-metabolic risk factors at 6 and 10 years. Design, Setting and participants Cortisol concentrations were measured in hair of 6-year-old children (n = 2,598) participating in the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. Main Outcome Measures Blood pressure, heart rate, concentrations of insulin, glucose, lipids and C-reactive protein in blood at 6 and 10 years. Results Higher hair cortisol concentrations at 6 years were associated with higher systolic blood pressure at 10 years (difference 0.17 standard deviation score (SDS) (95% Confidence Interval (CI) 0.03, 0.31)). The association attenuated into non-significance after adjustment for childhood BMI at 6 years. Higher hair cortisol concentrations at 6 years were associated with an increase in total and LDL cholesterol between 6 and 10 years but not with those measurements at 6 or 10 years. Hair cortisol concentrations were not associated with other cardio-metabolic risk factors at 6 or 10 years. Conclusions Hair cortisol concentrations were not independent of BMI associated with cardio-metabolic risk factors at 6 or 10 years. The associations of biological stress with cardio-metabolic risk factors may develop at later ages.

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