Preparation of redispersible dry emulsion using Eudragit E100 as both solid carrier and unique emulsifier

Aim: The present study focused on the development of a dry emulsion tablet of raloxifene hydrochloride (RXF) using a solid carrier adsorption technique to enhance oral bioavailability. Methods: An oil-in-water emulsion was formulated and converted into dry powder using HPMC K4M plus Aerosil 200, then compressed into tablets. Results: The prepared emulsion was evaluated for globule size, drug content and zeta potential. In vitro release study revealed significantly higher release from emulsion. The prepared tablets possessed acceptable hardness, friability, weight variation, disintegration time, thickness, etc. In vivo pharmacokinetic studies indicated a more than sevenfold increase in oral bioavailability. Stability studies indicated good physical and chemical stability of the developed formulation. Conclusion: The authors successfully formulated dry emulsion tablets with enhanced oral bioavailability.

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Preparation of fenofibrate dry emulsion and dry suspension using octenyl succinic anhydride starch as emulsifying agent and solid carrier

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2015.12.041 ◽

2016 ◽

Vol 498 (1-2) ◽

pp. 347-354 ◽

Cited By ~ 10

Author(s):

Kasama Pongsamart ◽

Peter Kleinebudde ◽

Satit Puttipipatkhachorn

Keyword(s):

Succinic Anhydride ◽

Solid Carrier ◽

Emulsifying Agent ◽

Octenyl Succinic Anhydride ◽

Dry Emulsion

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ChemInform Abstract: The Synthesis of (3′-5′)-Oligoribonucleotides on Solid Carrier

ChemInform ◽

10.1002/chin.199114359 ◽

2010 ◽

Vol 22 (14) ◽

pp. no-no

Author(s):

L. ARNOLD

Keyword(s):

Solid Carrier

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Indomethacin-5-fluorouracil-methyl ester dry emulsion: a potential oral delivery system for 5-fluorouracil

Drug Development and Industrial Pharmacy ◽

10.3109/03639040903410318 ◽

2010 ◽

Vol 36 (6) ◽

pp. 647-656 ◽

Cited By ~ 8

Author(s):

Jing Wang ◽

Yanchen Hu ◽

Ling Li ◽

Tongying Jiang ◽

Siling Wang ◽

...

Keyword(s):

Methyl Ester ◽

Delivery System ◽

Oral Delivery ◽

Oral Delivery System ◽

Dry Emulsion

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Physicochemical analysis in the evaluation of reconstituted dry emulsion tablets

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2016.11.031 ◽

2017 ◽

Vol 134 ◽

pp. 86-93 ◽

Cited By ~ 2

Author(s):

Noémi Anna Niczinger ◽

Barnabás Kállai-Szabó ◽

Miléna Lengyel ◽

Péter Gordon ◽

Imre Klebovich ◽

...

Keyword(s):

Physicochemical Analysis ◽

Dry Emulsion

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Identification of a Suitable Solid Carrier as a Matrix for the Permeable Reactive Barrier of Laboratory Scale Model Aquifer for Atrazine Degradation

Tribhuvan University Journal ◽

10.3126/tuj.v25i1.3754 ◽

1970 ◽

Vol 25 (1) ◽

pp. 119-128 ◽

Cited By ~ 1

Author(s):

Binita K Shrestha ◽

Pawan Raj Shakya ◽

MIM Soares

Keyword(s):

Laboratory Scale ◽

Permeable Reactive Barrier ◽

Scale Model ◽

Pseudomonas Sp ◽

Reactive Barrier ◽

Solid Carrier ◽

Different Types ◽

Simultaneous Loss ◽

Static Conditions ◽

Atrazine Degradation

Three different types of physical substrata such as sand, granualar activated carbon (GAC) and plastic macaroni beads were selected to identify a suitable solid carrier as a course matrix for the permeable reactive barrier (PRB) in a sand filled two-dimensional laboratory-scale model aquifer. An adhesion experiment was performed and tested with Pseudomonas sp ADP (PASP) under agitated as well as static conditions. In static conditions, adhesion to GAC was the highest (80%) followed by that to beads (60%). No adhesion to sand was observed under static or agitated conditions. Since atrazine is adsorbed by GAC, its bioavailability for degradation by PADP may be affected. To test this, simultaneous loss of atrazine and release of chloride (dechlorination, the first step in the pathway of atrazine degradation by PADP) were determined in the presence and absence of GAC. Although cells remained viable, no significant chloride release was detected. Thus, plastic macaroni beads were identified and selected as the most suitable support for PADP in the biological permeable reactive barrier (BPRB) of the model aquifer.Key words: Suitable Solid; Laboratory Scale; PADPTribhuvan University JournalVol. XXV, No. 1, 2005Page:119-128Uploaded date: 26, September, 2010

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Physicochemical Stability Study on Cyclosporine A Loaded Dry-Emulsion Formulation with Enhanced Solubility

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c14-00696 ◽

2015 ◽

Vol 63 (1) ◽

pp. 54-58 ◽

Cited By ~ 3

Author(s):

Hideyuki Sato ◽

Kumiko Ogawa ◽

Yoshiki Kojo ◽

Hiroki Suzuki ◽

Takahiro Mizumoto ◽

...

Keyword(s):

Cyclosporine A ◽

Stability Study ◽

Physicochemical Stability ◽

Enhanced Solubility ◽

Emulsion Formulation ◽

Dry Emulsion

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USE OF HYDROGEN PEROXIDE AND PERCARBONATE TO TREAT CHLORINATED AROMATIC HYDROCARBON-CONTAMINATED SOIL

Journal of Environmental Engineering and Landscape Management ◽

10.3846/16486897.2013.804827 ◽

2014 ◽

Vol 22 (1) ◽

pp. 30-39 ◽

Cited By ~ 20

Author(s):

Marika Viisimaa ◽

Anna Goi

Keyword(s):

Hydrogen Peroxide ◽

Soil Ph ◽

Liquid Hydrogen ◽

Natural Soil ◽

Contaminant Removal ◽

Contaminant Degradation ◽

Solid Carrier ◽

Liquid Carrier ◽

Initial Ph ◽

Ph Conditions

This study compared treatment methods that utilised a liquid carrier of hydrogen peroxide and a solid carrier, percarbonate, for p-dichlorobenzene, p-chloro-m-cresol and p-chlorothymol degradation in the soil. The targeted chlorinated aromatic contaminants in the soil degraded to a certain level when treated with the liquid hydrogen peroxide, but the removal efficacy was not dependent on the dosage. In contrast, an increase in the percarbonate dosage enhanced the contaminant removal. Supplementary ferrous iron was more effective for the treatment that employed the liquid carrier of hydrogen peroxide than the treatment employing the solid carrier. Although acidic pH conditions (initial pH of 2.5) favoured contaminant degradation using liquid hydrogen peroxide, the treatment involving percarbonate resulted in more effective contaminant removal without any soil pH preadjustment. Therefore, the solid carrier of hydrogen peroxide, percarbonate, was concluded to be an effective alternative to the liquid carrier, resulting in greater contaminant removal at natural soil pH values.

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