Surfactant effect on the physicochemical characteristics of γ-oryanol-containing solid lipid nanoparticles

Novel monosubstituted pillar[5]arenes containing both amide and carboxyl functional groups were synthesized. Solid lipid nanoparticles based on the synthesized macrocycles were obtained. Formation of spherical particles with an average hydrodynamic diameter of 250 nm was shown for pillar[5]arenes containing N-(amidoalkyl)amide fragments regardless of their concentration. It was established that pillar[5]arene containing N-alkylamide fragments can form spherical particles with two different sizes (88 and 223 nm) depending on its concentration. Mixed solid lipid nanoparticles based on monosubstituted pillar[5]arenes and surfactant (dodecyltrimethylammonium chloride) were obtained for the first time. The surfactant made it possible to level the effect of the macrocycle concentration. It was found that various types of aggregates are formed depending on the macrocycle/surfactant ratio. Changing the macrocycle/surfactant ratio allows to control the charge of the particles surface. This controlled property will lead to the creation of molecular-scale porous materials that selectively interact with various types of substrates, including biopolymers.

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Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

Therapeutic Delivery ◽

10.4155/tde-2020-0075 ◽

2020 ◽

Vol 11 (11) ◽

pp. 685-700

Author(s):

Omar Sarheed ◽

Douha Shouqair ◽

KVRNS Ramesh ◽

Muhammad Amin ◽

Joshua Boateng ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Skin Permeation ◽

Tween 80 ◽

Physicochemical Characteristics ◽

Lipid Nanoparticles ◽

Water Addition ◽

Oil Emulsion ◽

Solid Lipid ◽

Ultrasound Assisted

Aim: To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process. Results/methodology: Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine. Conclusion: Stable SLNs were successfully prepared by ultrasound-assisted PIT.

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Effect of Lipids on Physicochemical Properties of Letrozole Loaded Solid Lipid Nanoparticles

International Journal of Pharmaceutical Sciences and Drug Research ◽

10.25004/ijpsdr.2016.080501 ◽

2016 ◽

Vol 8 (05) ◽

Author(s):

Archana Nerella ◽

Basava Dontamsetti ◽

Aruna Mantena

Keyword(s):

Particle Size ◽

Physicochemical Properties ◽

Solid Lipid Nanoparticles ◽

In Vitro Release ◽

Physicochemical Characteristics ◽

Lipid Nanoparticles ◽

Solid Lipid ◽

Stabilizer Concentration ◽

Vitro Release

The objective of the current investigation was to prepare solid lipid nanoparticles (SLNs) from different lipids and to study the effect of lipids on physicochemical characteristics of letrozole loaded SLN. In order to prepare small, stable, uniform and high Letrozole loaded SLNs, many factors such as lipid and stabilizer concentration and preparation parameters can be considered. Out of these, we have selected solid lipid as lipid matrix to investigate an effect on SLNs. SLNs were prepared using different lipids by modified hot sonication method. The effect of different lipids and stabilizers on physicochemical characteristics of Letrozole loaded SLNs were investigated. Letrozole loaded SLNs showed different physicochemical properties and release profiles according to used solid lipid. In case of particle size, SLN1 showed biggest particle size (532.5 ± 26.4nm) and highest encapsulation efficiency (81.37 ± 6.72%) and, SLN4 showed highest cumulative drug percentage (89.4 ± 1.8%, 24 h) release. These results suggest that lipids type affect physicochemical properties and release profile of SLN. The choice of lipid and stabilizer played important role on the physicochemical characteristics and in vitro release of Letrozole loaded SLNs.

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