Surfactant Effect on the Physicochemical Characteristics of Solid Lipid Nanoparticles Based on Pillar[5]arenes

Novel monosubstituted pillar[5]arenes containing both amide and carboxyl functional groups were synthesized. Solid lipid nanoparticles based on the synthesized macrocycles were obtained. Formation of spherical particles with an average hydrodynamic diameter of 250 nm was shown for pillar[5]arenes containing N-(amidoalkyl)amide fragments regardless of their concentration. It was established that pillar[5]arene containing N-alkylamide fragments can form spherical particles with two different sizes (88 and 223 nm) depending on its concentration. Mixed solid lipid nanoparticles based on monosubstituted pillar[5]arenes and surfactant (dodecyltrimethylammonium chloride) were obtained for the first time. The surfactant made it possible to level the effect of the macrocycle concentration. It was found that various types of aggregates are formed depending on the macrocycle/surfactant ratio. Changing the macrocycle/surfactant ratio allows to control the charge of the particles surface. This controlled property will lead to the creation of molecular-scale porous materials that selectively interact with various types of substrates, including biopolymers.

Study on Binary Mixture System of Lauroyl Sodium Glutamate Surfactant

In the present study, binary mixtures of sodium N-lauroylglutamate (SLG) and dodecyltrimethylammonium chloride (DTAC) or dodecylbetaine (BS-12) were examined for their synergistic effect. The surface chemical properties of the compound systems with different molar ratios were determined by the regular solution theory. Results indicated that both compound systems show synergistic effects of overall synergy, in which the SLG/DTAC system exhibited a better activity than the SLG/BS-12 system. The aggregation number of SLG compound systems was smaller than that of single surfactants, and the difference of the proportion of the two surfactants had little effect on the aggregation number of compound systems.