scholarly journals Surfactant Effect on the Physicochemical Characteristics of Solid Lipid Nanoparticles Based on Pillar[5]arenes

2022 ◽  
Vol 23 (2) ◽  
pp. 779
Author(s):  
Anastasia Nazarova ◽  
Luidmila Yakimova ◽  
Darya Filimonova ◽  
Ivan Stoikov
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physicochemical Characteristics ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Hydrodynamic Diameter ◽  
Solid Lipid ◽  
Molecular Scale ◽  
Dodecyltrimethylammonium Chloride ◽  
First Time ◽  
Average Hydrodynamic Diameter

Novel monosubstituted pillar[5]arenes containing both amide and carboxyl functional groups were synthesized. Solid lipid nanoparticles based on the synthesized macrocycles were obtained. Formation of spherical particles with an average hydrodynamic diameter of 250 nm was shown for pillar[5]arenes containing N-(amidoalkyl)amide fragments regardless of their concentration. It was established that pillar[5]arene containing N-alkylamide fragments can form spherical particles with two different sizes (88 and 223 nm) depending on its concentration. Mixed solid lipid nanoparticles based on monosubstituted pillar[5]arenes and surfactant (dodecyltrimethylammonium chloride) were obtained for the first time. The surfactant made it possible to level the effect of the macrocycle concentration. It was found that various types of aggregates are formed depending on the macrocycle/surfactant ratio. Changing the macrocycle/surfactant ratio allows to control the charge of the particles surface. This controlled property will lead to the creation of molecular-scale porous materials that selectively interact with various types of substrates, including biopolymers.

Surfactant effect on the physicochemical characteristics of cationic solid lipid nanoparticles

2017 ◽  
Vol 516 (1-2) ◽  
pp. 334-341 ◽  
Author(s):  
Chiara Botto ◽  
Nicolò Mauro ◽  
Erika Amore ◽  
Elisabetta Martorana ◽  
Gaetano Giammona ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physicochemical Characteristics ◽  
Lipid Nanoparticles ◽  
Surfactant Effect ◽  
Solid Lipid

Production of Ibuprofen-Loaded Solid Lipid Nanoparticles Using Rapid Expansion of Supercritical Solution

2015 ◽  
Vol 31 ◽  
pp. 15-29 ◽  
Author(s):  
Zahra Akbari ◽  
Massoud Amanlou ◽  
Javad Karimi-Sabet ◽  
Abolfazl Golestani ◽  
Mojtaba Shariaty Niassar
Keyword(s):  
Stearic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Rapid Expansion ◽  
Spherical Particles ◽  
Oral Drug ◽  
Dissolution Profile ◽  
Lipid Matrix ◽  
Solid Lipid ◽  
Supercritical Solution

The purpose of this study was to prepare ibuprofen loaded solid lipid nanoparticles (IBU-SLNs) that is, effective in oral drug delivery. IBU-SLNs were synthesized by co-precipitation of rapid expansion of supercritical solution (CO-RESS). The produced SLNs consisted of stearic acid as lipid matrix. The unprocessed stearic acid, ibuprofen and IBU-SLNs were characterized by means of scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), fourier transform infrared spectrophotometry (FTIR) and high performance liquid chromatography (HPLC). XRD patterns along with DSC showed that ibuprofen was present in both amorphous and crystalline form within lipid matrix. FTIR showed that molecular interactions that could alter the chemical structure of the IBU did not occur. The RESS process could produce ultrafine spherical particles of SLNs with high drug loading capacity. The IBU dissolution profile showed that the formulated SLNs have effectively increased the IBU solubility

scholarly journals Formulation, Characterization and in-vitro Evaluation of Famciclovir Loaded Solid Lipid Nanoparticles for Improved Oral Absorption

2020 ◽  
pp. 1-17
Author(s):  
Pavan Kumar Rawat ◽  
Chandra Kishore Tyagi ◽  
Sunil Kumar Shah ◽  
Arun Kumar Pandey
Keyword(s):  
Particle Size ◽  
Electron Microscope ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Average Particle ◽  
Preparation Technique ◽  
Solid Lipid ◽  
Freeze Dried

Famciclovir loaded Solid Lipid Nanoparticles (SLNs) using triglycerides as solid lipids were successfully prepared using the double emulsion-solvent evaporation technique. Formulation parameters like amount and type of lipid and level of surfactants affected the nanoparticle characters. It was observed that nanoparticle characters like average particle size and distribution, drug content, entrapment efficiency and release pattern were dependent on these formulation variables. The optimized formulations depicted the desired characters of low particle size, in the range of 140-170 nm in case of Glyceryl monostearate (GMS) and glyceryl distearate (GDS) SLNs and 250-340 nm in case of glyceryl behenate (GB) SLNs and entrapment efficiencies in the range of 35-48%. In vitro drug release was extended upto 8 h and the release profile was explained by the Baker-Lonsdale model for spherical particles. Morphological examination by Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) displayed homogenous solid, spherical and non- porous particles. The formulations depicted good redispersibility after lyophilization and presence of residual solvents in the formulations within the prescribed limits suggested suitability of the preparation technique. Freeze- dried formulations were found to be stable in terms of particle size and drug loading even after 6 months of storage at refrigerated conditions.

Griseofulvin Solid Lipid Nanoparticles Based on Microemulsion Technique

2011 ◽  
Vol 197-198 ◽  
pp. 47-50 ◽  
Author(s):  
Lorwongngam Anurak ◽  
Gaysorn Chansiri ◽  
Dangprasert Peankit ◽  
Kongmuang Somlak
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Water Solubility ◽  
Chemical Properties ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Solid Lipid ◽  
Dialysis Method ◽  
The Mean ◽  
Physical And Chemical ◽  
And Chemical Properties

The need for a topical drug delivery system of griseofulvin (GF) is dued to its poor oral bioavailability because of its low water solubility and excessively side effects. The preparation of griseofulvin-loaded into solid lipid nanoparticles (GF-SLNs) to nanometer range is expected to improve the dissolution rate by increasing the specific surface area. The aim of investigation was to produce griseofulvin-loaded into solid lipid nanoparticles by using a simple microemulsion technique, using glyceryl monostearate as solid lipid, polysorbate 20 as emulsifier, butanol and Transcutol HP®as co-emulsifiers. The GF-SLNs were evaluated for physical and chemical properties including GF release from GF-SLNs. The spherical particles were observed by TEM. The mean particle size of GF-SLNs was 165 nm and the zeta potential of GF-SLNs was -36 mV. There were interactions between GF and excipients in formula. The GF releasing profiles were obtained by a dialysis method with pH 5.5 phosphate buffer as medium, the release profile of GF was to be a prolong release of 63.53% within 12 hours.

scholarly journals Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

2020 ◽  
Vol 11 (11) ◽  
pp. 685-700
Author(s):  
Omar Sarheed ◽  
Douha Shouqair ◽  
KVRNS Ramesh ◽  
Muhammad Amin ◽  
Joshua Boateng ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Skin Permeation ◽  
Tween 80 ◽  
Physicochemical Characteristics ◽  
Lipid Nanoparticles ◽  
Water Addition ◽  
Oil Emulsion ◽  
Solid Lipid ◽  
Ultrasound Assisted

Aim: To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process. Results/methodology: Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine. Conclusion: Stable SLNs were successfully prepared by ultrasound-assisted PIT.

Surfactant effect on the physicochemical characteristics of γ-oryanol-containing solid lipid nanoparticles

2016 ◽  
Vol 488 ◽  
pp. 118-128 ◽  
Author(s):  
Kullavadee Karn-orachai ◽  
Siwaporn Meejoo Smith ◽  
Somsak Saesoo ◽  
Alongkot Treethong ◽  
Satit Puttipipatkhachorn ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physicochemical Characteristics ◽  
Lipid Nanoparticles ◽  
Surfactant Effect ◽  
Solid Lipid

Optimization of Solid Lipid Nanoparticles and Nanostructured Lipidic Carriers as Promising delivery for Gefitinib: Characterization and Invitro Evaluation.

2021 ◽  
Vol 16 ◽  
Author(s):  
Akshat Shah ◽  
Asha Patel ◽  
Abhay Dharamsi
Keyword(s):  
Particle Size ◽  
Response Surface Methodology ◽  
Zeta Potential ◽  
Response Surface ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Spherical Particles ◽  
Independent Variables ◽  
Solid Lipid ◽  
Optimized Conditions

Background: Response surface methodology is a unique tool for the optimization of Solid lipid Nanoparticles and Nanostructured lipid carriers by developing the relationship between dependent and independent variables and exploring their interactions. Methods: Central Composite Design and Box Benkhen Design was used to develop optimized formulations of Gefitinib [GEF] Solid Lipid Nanoparticles [SLN] and Nanostructured Lipidic Carriers [NLC]. In the design matrix, the independent variables chosen were the amount of Solid Lipid, Liquid Lipid, and Surfactant and dependent variables were Particle Size and Poly Dispersity Index. Result: The GEF-SLN under optimized conditions gave rise to Particle size (187.9 nm ± 1.15), PDI (0.318 ± 0.006), %EE (95.38%±0.14), Zeta Potential (-8.75 mv ±0.18) and GEF-NLC under optimized conditions gave rise to Particle size (188.6 nm± 1.12), PDI (0.395± 0.004), %EE (97.46%± 0.33), Zeta Potential (-5.72 mv± 0.04) respectively. SEM of the Freeze-dried optimized lipidic carriers showed spherical particles. The in vitro experiments proved that Gefitinib in the lipidic carriers is released gradually throughout 24 h. Conclusion: This study showed that the response surface methodology could be efficiently applied for the modeling of GEF-SLN & GEF-NLC.

scholarly journals Effect of Lipids on Physicochemical Properties of Letrozole Loaded Solid Lipid Nanoparticles

2016 ◽  
Vol 8 (05) ◽  
Author(s):  
Archana Nerella ◽  
Basava Dontamsetti ◽  
Aruna Mantena
Keyword(s):  
Particle Size ◽  
Physicochemical Properties ◽  
Solid Lipid Nanoparticles ◽  
In Vitro Release ◽  
Physicochemical Characteristics ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Stabilizer Concentration ◽  
Vitro Release

The objective of the current investigation was to prepare solid lipid nanoparticles (SLNs) from different lipids and to study the effect of lipids on physicochemical characteristics of letrozole loaded SLN. In order to prepare small, stable, uniform and high Letrozole loaded SLNs, many factors such as lipid and stabilizer concentration and preparation parameters can be considered. Out of these, we have selected solid lipid as lipid matrix to investigate an effect on SLNs. SLNs were prepared using different lipids by modified hot sonication method. The effect of different lipids and stabilizers on physicochemical characteristics of Letrozole loaded SLNs were investigated. Letrozole loaded SLNs showed different physicochemical properties and release profiles according to used solid lipid. In case of particle size, SLN1 showed biggest particle size (532.5 ± 26.4nm) and highest encapsulation efficiency (81.37 ± 6.72%) and, SLN4 showed highest cumulative drug percentage (89.4 ± 1.8%, 24 h) release. These results suggest that lipids type affect physicochemical properties and release profile of SLN. The choice of lipid and stabilizer played important role on the physicochemical characteristics and in vitro release of Letrozole loaded SLNs.

Sign in / Sign up

Export Citation Format

Share Document