A supramolecular nanoparticle system based on β-cyclodextrin-conjugated poly-l-lysine and hyaluronic acid for co-delivery of gene and chemotherapy agent targeting hepatocellular carcinoma

2017 ◽  
Vol 155 ◽  
pp. 93-103 ◽  
Author(s):  
Qingqing Xiong ◽  
Mangmang Cui ◽  
Yang Bai ◽  
Yuanyuan Liu ◽  
Di Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hyaluronic Acid ◽  
Chemotherapy Agent ◽  
Nanoparticle System

Hyaluronic acid-shelled, peptide drug conjugate-cored nanomedicine for the treatment of hepatocellular carcinoma

2020 ◽  
Vol 117 ◽  
pp. 111261
Author(s):  
Jingjing Wang ◽  
Ying Qian ◽  
Liu Xu ◽  
Yurou Shao ◽  
Hu Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hyaluronic Acid ◽  
Peptide Drug ◽  
Drug Conjugate

scholarly journals siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy

2018 ◽  
Vol Volume 13 ◽  
pp. 1539-1552 ◽  
Author(s):  
Yu Xia ◽  
Min Guo ◽  
Tiantian Xu ◽  
Yinghua Li ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hyaluronic Acid ◽  
Selenium Nanoparticle

scholarly journals The Role of Non-Coding RNAs in the Sorafenib Resistance of Hepatocellular Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Xinyao Hu ◽  
Hua Zhu ◽  
Yang Shen ◽  
Xiaoyu Zhang ◽  
Xiaoqin He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Mechanisms ◽  
Vital Role ◽  
Circular Rnas ◽  
First Line ◽  
Advanced Hcc ◽  
Chemotherapy Agent ◽  
Development Of Resistance ◽  
Non Coding Rnas

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Sorafenib is approved by the U.S. Food and Drug Administration to be a first-line chemotherapy agent for patients with advanced HCC. A portion of advanced HCC patients can benefit from the treatment with sorafenib, but many patients ultimately develop sorafenib resistance, leading to a poor prognosis. The molecular mechanisms of sorafenib resistance are sophisticated and indefinite. Notably, non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), are critically participated in the occurrence and progression of tumors. Moreover, growing evidence has suggested that ncRNAs are crucial regulators in the development of resistance to sorafenib. Herein, we integrally and systematically summarized the molecular mechanisms and vital role of ncRNAs impact sorafenib resistance of HCC, and ultimately explored the potential clinical administrations of ncRNAs as new prognostic biomarkers and therapeutic targets for HCC.

Prognostic significance of preoperative hyaluronic acid level in patients with hepatocellular carcinoma

HPB ◽  
2021 ◽  
Author(s):  
Takatsugu Matsumoto ◽  
Taku Aoki ◽  
Takayuki Shimizu ◽  
Kyung Hwa Park ◽  
Takayuki Shiraki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hyaluronic Acid ◽  
Acid Level ◽  
Prognostic Significance

A multifunctional nanoparticle system combines sonodynamic therapy and chemotherapy to treat hepatocellular carcinoma

Nano Research ◽  
2017 ◽  
Vol 10 (3) ◽  
pp. 834-855 ◽  
Author(s):  
Yang Liu ◽  
Guoyun Wan ◽  
Hua Guo ◽  
Yuanyuan Liu ◽  
Ping Zhou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sonodynamic Therapy ◽  
Multifunctional Nanoparticle ◽  
Nanoparticle System
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