Temperature and neuronal circuit function: compensation, tuning and tolerance

2012 ◽  
Vol 22 (4) ◽  
pp. 724-734 ◽  
Author(s):  
R Meldrum Robertson ◽  
Tomas GA Money
Keyword(s):  
Neuronal Circuit ◽  
Circuit Function

Internalization of Carbon Nano-onions by Hippocampal Cells Preserves Neuronal Circuit Function and Recognition Memory

2018 ◽  
Vol 10 (20) ◽  
pp. 16952-16963 ◽  
Author(s):  
Massimo Trusel ◽  
Michele Baldrighi ◽  
Roberto Marotta ◽  
Francesca Gatto ◽  
Mattia Pesce ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Neuronal Circuit ◽  
Circuit Function

scholarly journals Prototypical pacemaker neurons interact with the resident microbiota

2020 ◽  
Vol 117 (30) ◽  
pp. 17854-17863 ◽  
Author(s):  
Alexander Klimovich ◽  
Stefania Giacomello ◽  
Åsa Björklund ◽  
Louis Faure ◽  
Marketa Kaucka ◽  
...  
Keyword(s):  
Strong Support ◽  
Neuronal Circuit ◽  
Pacemaker Cells ◽  
Pacemaker Neurons ◽  
Basal Metazoan ◽  
Rhythmic Contractions ◽  
Microbial Environment ◽  
Immune Related Genes ◽  
Evolutionary Emergence ◽  
Circuit Function

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of these neurons and their interaction with microbes. In this study, we identified and functionally characterized prototypical ANO/SCN/TRPM ion channel-expressing pacemaker cells in the basal metazoanHydraby using a combination of single-cell transcriptomics, immunochemistry, and functional experiments. Unexpectedly, these prototypical pacemaker neurons express a rich set of immune-related genes mediating their interaction with the microbial environment. Furthermore, functional experiments gave a strong support to a model of the evolutionary emergence of pacemaker cells as neurons using components of innate immunity to interact with the microbial environment and ion channels to generate rhythmic contractions.

scholarly journals Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

2017 ◽  
Vol 42 (6) ◽  
pp. 1810-1822 ◽  
Author(s):  
Celia Kjaerby ◽  
Rune Rasmussen ◽  
Mie Andersen ◽  
Maiken Nedergaard
Keyword(s):  
Calcium Signaling ◽  
State Transitions ◽  
Brain State ◽  
Neuronal Circuit ◽  
Circuit Function

scholarly journals Prototypical pacemaker neurons are immunocompetent cells

2019 ◽  
Author(s):  
Alexander Klimovich ◽  
Stefania Giacomello ◽  
Åsa Björklund ◽  
Louis Faure ◽  
Marketa Kaucka ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Neuronal Circuit ◽  
Pacemaker Cells ◽  
Pacemaker Neurons ◽  
Basal Metazoan ◽  
Rhythmic Contractions ◽  
Microbial Environment ◽  
Immune Related Genes ◽  
Evolutionary Emergence ◽  
Circuit Function

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of these neurons and their interaction with microbes. In this study, we identified and functionally characterized prototypical ANO/SCN/TRPM ion channel expressing pacemaker cells in the basal metazoan Hydra by using a combination of single-cell transcriptomics, immunochemistry, and functional experiments. Unexpectedly, these prototypical pacemaker neurons express a rich set of immune-related genes mediating their interaction with the microbial environment. Functional experiments validated a model of the evolutionary emergence of pacemaker cells as neurons using components of innate immunity to interact with the microbial environment and ion channels to generate rhythmic contractions.

Microfabrication research at the National Submicron Facility

1983 ◽  
Vol 41 ◽  
pp. 86-89
Author(s):  
E.D. Wolf
Keyword(s):  
Integrated Circuits ◽  
Particle Physics ◽  
High Speed ◽  
New Technology ◽  
High Energy ◽  
High Energy Particle ◽  
New Science ◽  
Wide Range ◽  
Intermediate Domain ◽  
Circuit Function

Most microelectronics devices and circuits operate faster, consume less power, execute more functions and cost less per circuit function when the feature-sizes internal to the devices and circuits are made smaller. This is part of the stimulus for the Very High-Speed Integrated Circuits (VHSIC) program. There is also a need for smaller, more sensitive sensors in a wide range of disciplines that includes electrochemistry, neurophysiology and ultra-high pressure solid state research. There is often fundamental new science (and sometimes new technology) to be revealed (and used) when a basic parameter such as size is extended to new dimensions, as is evident at the two extremes of smallness and largeness, high energy particle physics and cosmology, respectively. However, there is also a very important intermediate domain of size that spans from the diameter of a small cluster of atoms up to near one micrometer which may also have just as profound effects on society as “big” physics.

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