Self-described impact of noncompliance among users of a combined hormonal contraceptive method

Abstract Purpose of Review In this review, we discuss the efficacy, safety, and benefits of four new contraceptive products available in the USA, specifically Annovera, Phexxi, Slynd, and Twirla. Recent Findings Annovera is a vaginal ring releasing ethinyl estradiol and segesterone acetate that can be used for up to one year (13 cycles), offering patients an effective, user-controlled option that may improve contraceptive access for those in low-resource settings or those with barriers to retrieving monthly prescriptions; however, given limited efficacy and safety data in people with body mass index (BMI) > 29 kg/m2, clinicians may consider whether Annovera is an appropriate contraceptive method for obese patients if there are other acceptable alternatives. Phexxi prescription-only vaginal gel is a user-controlled, non-hormonal, on-demand contraceptive method that represents a novel addition to the market with its additional uses as a personal lubricant and as a potential microbicide for urogenital infection prevention. Slynd, a drospirenone-only pill, provides more flexibility for delayed or missed pills while maintaining efficacy and a more favorable bleeding profile compared with previously available progestin-only pills. Lastly, Twirla is a transdermal patch releasing ethinyl estradiol and levonorgestrel that offers users an additional option for a user-controlled, combined hormonal contraceptive method without daily dosing; however, prescription is limited to patients with BMI < 30 kg/m2 due to decreased efficacy and VTE events in people with obesity. Summary The addition of these products expands the available options for pregnancy prevention to address unmet contraceptive needs.

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Impact of counselling on selecting a hormonal contraceptive method

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183339 ◽

2018 ◽

Vol 7 (8) ◽

pp. 3325

Author(s):

Darshna M. Patel ◽

Vandita K. Salat ◽

Mahesh M. Patel

Keyword(s):

Family Planning ◽

Health Care Professionals ◽

Contraceptive Method ◽

Unmet Need ◽

Hormonal Contraceptive ◽

Maximum Difference ◽

Contraceptive Methods ◽

Important Indicator ◽

Contraceptive Pills ◽

Combined Hormonal Contraceptive

Background: Unmet need for family planning is an important indicator for assessing the demand for family planning services. As per NFHS-4, the contraceptive prevalence rate in women age 15-49 years was 53.5 % and the unmet need for family planning among married women was 12.9%. Counselling provides the Health care professionals (HCPs) an opportunity to understand the individual need of a contraceptive seeker.Methods: This was a cross-sectional, observational study conducted at GMERS hospital, Valsad during June 2017 to October 2017. Sexually active women of 18 to 40 years who consulted HCPs for contraception and who interested in starting hormonal contraceptive method or expressed interest in switching (changing) to hormonal methods were included in the study. Total 213 women were enrolled in the study. Questionnaires with information on the women’s pre- and post-counseling contraceptive choice, her perceptions, and the reasons behind her post-counseling decision were filled both by the HCP and the participating women. The completed questionnaires were collected and analyzed.Results: During pre-counseling, most common hormonal contraceptive method selected by women was combined hormonal contraceptive pills followed by DMPA, LNG-IUS and POPs. In present study, structured contraception counseling helped most women (97.2 %) to choose a contraceptive method. There were statistically significant differences in choice of contraceptive methods during pre and post-counseling except COCs. Among hormonal contraceptive methods, maximum difference was observed for choice of the COCs after counseling as compared to pre-counseling. Counseling helped more than 90% of the women who were indecisive to choose any contraceptive method. More than three fourth of them opted for hormonal methods with a maximum selection of COCs. The most common reasons for selecting COCs was ease of use for COC, breast feeding for POP and the most common reasons for not choosing other available contraceptive methods was discussion with partner.Conclusions: The combined hormonal contraceptive pills were reported to be the most commonly used contraceptive method. There were statistically significant differences in choice of contraceptive methods during pre and post-counseling with maximum difference in COCs. Counseling helped most of the women who were indecisive to choose any contraceptive method.

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Factors affecting women's selection of a combined hormonal contraceptive method: the TEAM-06 Spanish cross-sectional study

Contraception ◽

10.1016/j.contraception.2007.04.014 ◽

2007 ◽

Vol 76 (2) ◽

pp. 77-83 ◽

Cited By ~ 45

Author(s):

Iñaki Lete ◽

Jose Luis Doval ◽

Ezequiel Pérez-Campos ◽

Rafael Sánchez-Borrego ◽

Marta Correa ◽

...

Keyword(s):

Contraceptive Method ◽

Hormonal Contraceptive ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Factors Affecting ◽

Selection Of ◽

Combined Hormonal Contraceptive

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Medical contraindications to combined hormonal contraceptive use among women using methods prescribed by a pharmacist

Contraception ◽

10.1016/j.contraception.2021.06.004 ◽

2021 ◽

Author(s):

Maria I. Rodriguez ◽

Menolly Kaufman ◽

Brynna Manibusan ◽

Lorinda Anderson ◽

K. John McConnell

Keyword(s):

Contraceptive Use ◽

Hormonal Contraceptive ◽

Combined Hormonal Contraceptive

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Hormonal contraceptive method choice among young, low-income women: How important is the provider?

Patient Education and Counseling ◽

10.1016/j.pec.2010.08.010 ◽

2010 ◽

Vol 81 (3) ◽

pp. 349-354 ◽

Cited By ~ 46

Author(s):

Cynthia C. Harper ◽

Beth A. Brown ◽

Anne Foster-Rosales ◽

Tina R. Raine

Keyword(s):

Low Income ◽

Contraceptive Method ◽

Hormonal Contraceptive ◽

Method Choice ◽

Low Income Women

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Hormonal contraception and HIV acquisition among women: an updated systematic review

BMJ Sexual & Reproductive Health ◽

10.1136/bmjsrh-2019-200509 ◽

2020 ◽

Vol 46 (1) ◽

pp. 8-16 ◽

Cited By ~ 6

Author(s):

Kathryn M Curtis ◽

Philip C Hannaford ◽

Maria Isabel Rodriguez ◽

Tsungai Chipato ◽

Petrus S Steyn ◽

...

Keyword(s):

Systematic Review ◽

Observational Study ◽

Oral Contraceptives ◽

Hiv Risk ◽

Contraceptive Method ◽

Hormonal Contraception ◽

Hormonal Contraceptive ◽

Contraception Use ◽

Hiv Acquisition ◽

Risk Of Hiv Acquisition

ObjectiveTo update a 2016 systematic review on hormonal contraception use and HIV acquisition.MethodsWe searched Pubmed and Embase between 15 January 2016 and 26 June 2019 for longitudinal studies comparing incident HIV infection among women using a hormonal contraceptive method and either non-users or users of another specific hormonal contraceptive method. We extracted information from newly identified studies, assessed study quality, and updated forest plots and meta-analyses.ResultsIn addition to 31 previously included studies, five more were identified; three provided higher quality evidence. A randomised clinical trial (RCT) found no statistically significant differences in HIV risk among users of intramuscular depot medroxyprogesterone acetate (DMPA-IM), levonorgestrel implant (LNG implant) or the copper intrauterine device (Cu-IUD). An observational study found no statistically significant differences in HIV risk among women using DMPA, norethisterone enanthate (NET-EN), implants (type not specified) or Cu-IUD. Updated results from a previously included observational study continued to find a statistically significant increased HIV risk with oral contraceptives and DMPA compared with no contraceptive use, and found no association between LNG implant and HIV risk.ConclusionsHigh-quality RCT data comparing use of DMPA, LNG implant and Cu-IUD does not support previous concerns from observational studies that DMPA-IM use increases the risk of HIV acquisition. Use of other hormonal contraceptive methods (oral contraceptives, NET-EN and implants) is not associated with an increased risk of HIV acquisition.

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Temporal relations in hormone-withdrawal migraines and impact on prevention- a diary-based pilot study in combined hormonal contraceptive users

The Journal of Headache and Pain ◽

10.1186/s10194-017-0801-7 ◽

2017 ◽

Vol 18 (1) ◽

Cited By ~ 3

Author(s):

Gabriele S. Merki-Feld ◽

Gina Epple ◽

Nina Caveng ◽

Bruno Imthurn ◽

Burkhardt Seifert ◽

...

Keyword(s):

Pilot Study ◽

Hormonal Contraceptive ◽

Temporal Relations ◽

Combined Hormonal Contraceptive

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Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus)

International Journal of Endocrinology ◽

10.1155/2019/2047803 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Rosângela C. Rodrigues ◽

Flávia Schechtman Belham ◽

Ana Garcia ◽

Corina Satler ◽

Carlos Tomaz ◽

...

Keyword(s):

Contraceptive Use ◽

Treatment Phase ◽

Coagulation Factors ◽

Hormonal Contraceptive ◽

Hormonal Contraceptives ◽

Primate Research ◽

Blood Coagulation Factors ◽

Physiological Impact ◽

Continuous Use ◽

Combined Hormonal Contraceptive

This study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female S. libidinosus from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. The physiological parameters were accessed by means of 13 blood samples from each female, whereas three were gathered during the baseline and 10 samples were collected during the treatment phase. The results showed that the contraceptive use provoked changes in hematological coagulation factors such as an increase in the amount of platelets (p=0.039) and a reduction in both prothrombin (p<0.001) and thromboplastin coagulation time (p<0.001). These results are similar to what has been observed in human patients; thus, it is concluded that S. libidinosus can be successfully used in studies about the physiological impact of hormonal contraceptives.

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