Bio-inspired novel design principles for artificial molecular motors

2010 ◽  
Vol 21 (5) ◽  
pp. 683-689 ◽  
Author(s):  
Thorsten Hugel ◽  
Christina Lumme
Keyword(s):  
Molecular Motors ◽  
Design Principles ◽  
Novel Design

Artificial Molecular Motors Powered by Light

2006 ◽  
Vol 59 (3) ◽  
pp. 157 ◽  
Author(s):  
Alberto Credi
Keyword(s):  
Molecular Motors ◽  
Energy Supply ◽  
Molecular Size ◽  
Design Principles ◽  
Light Energy ◽  
Bottom Up ◽  
Waste Products ◽  
Photochemical Processes ◽  
Autonomous Operation

The bottom-up construction and operation of machines and motors of molecular size is a topic of great interest in nanoscience, and a fascinating challenge of nanotechnology. The problem of the energy supply to make molecular motors work is of the greatest importance. Research in the last ten years has demonstrated that light energy can indeed be used to power artificial nanomotors by exploiting photochemical processes in appropriately designed systems. More recently, it has become clear that under many aspects light is the best choice to power molecular motors; for example, systems that show autonomous operation and do not generate waste products can be obtained. This review is intended to discuss the design principles at the basis of light-driven artificial nanomotors, and provide an up-to-date overview on the prototype systems that have been developed.

scholarly journals FUNCTIONAL ELECTRICAL STIMULATION FOR NEURO REHABILITATION. A NEW DESIGN PARADIGM

2012 ◽  
Vol 02 (03) ◽  
pp. 14-15
Author(s):  
Subramanya K. ◽  
Ajithanjaya Kumar Mijar Kanakabettu
Keyword(s):  
Electrical Stimulation ◽  
Electrical Activity ◽  
Functional Electrical Stimulation ◽  
Neurological Disorders ◽  
Closed Loop ◽  
Design Principles ◽  
Ideal Candidate ◽  
Design Paradigm ◽  
Stimulation Current ◽  
Novel Design

AbstractOne of the most exciting recent advances in the neuroprosthetics field has been the application of biosignals in the design of functional electrical stimulation (FES) devices. An Electromyogram (EMG) measures the electrical activity in muscles and is often considered as ideal candidate biosignal for designing closed-loop controlled FES system. In this brief communication, we propose a novel design paradigm of a synergistic benefit of incorporating two different design principles in development of an EMG controlled FES system that hold promise for the future of rehabilitation of stroke and other neurological disorders. The proposed system will detect the residual EMG signals from the muscle and suitably adjust the stimulation current amplitude and stimulate the paralyzed muscles with a 'natural' EMG pattern envelope. We offer this design as a fruitful area for fuing recent advances in the neuroprosthetics field has been the application of biosignals in the design of functional electrical stimulation (FES) devices. An Electromyogram (EMG) measures the electrical activity in muscles and is often considered as ideal candidate biosignal for designing closed-loop controlled FES system. In this brief communication, we propose a novel design paradigm of a synergistic benefit of incorporating two different design principles in development of an EMG controlled FES system that hold promise for the future of rehabilitation of stroke and other neurological disorders. The proposed system will detect the residual EMG signals from the muscle and suitably adjust the stimulation current amplitude and stimulate the paralyzed muscles with a 'natural' EMG pattern envelope. We offer this design as a fruitful area for future research and clinical application.

scholarly journals Evolutionary design principles in metabolism

2019 ◽  
Vol 286 (1898) ◽  
pp. 20190098 ◽  
Author(s):  
Gayathri Sambamoorthy ◽  
Himanshu Sinha ◽  
Karthik Raman
Keyword(s):  
Protein Interactions ◽  
Metabolic Networks ◽  
Design Principles ◽  
Dynamic Environments ◽  
Evolutionary Design ◽  
Protein Protein Interactions ◽  
Flux Coupling ◽  
A Cell ◽  
And Function ◽  
Novel Design

Microorganisms are ubiquitous and adapt to various dynamic environments to sustain growth. These adaptations accumulate, generating new traits forming the basis of evolution. Organisms adapt at various levels, such as gene regulation, signalling, protein–protein interactions and metabolism. Of these, metabolism forms the integral core of an organism for maintaining the growth and function of a cell. Therefore, studying adaptations in metabolic networks is crucial to understand the emergence of novel metabolic capabilities. Metabolic networks, composed of enzyme-catalysed reactions, exhibit certain repeating paradigms or design principles that arise out of different selection pressures. In this review, we discuss the design principles that are known to exist in metabolic networks, such as functional redundancy, modularity, flux coupling and exaptations. We elaborate on the studies that have helped gain insights highlighting the interplay of these design principles and adaptation. Further, we discuss how evolution plays a role in exploiting such paradigms to enhance the robustness of organisms. Looking forward, we predict that with the availability of ever-increasing numbers of bacterial, archaeal and eukaryotic genomic sequences, novel design principles will be identified, expanding our understanding of these paradigms shaped by varied evolutionary processes.

scholarly journals Controlling Singlet Fission with Coordination Chemistry-Induced Assembly of Dipyridyl Pyrrole Bipentacenes

2020 ◽  
Author(s):  
Ryan Ribson ◽  
Gyeongshin Choi ◽  
Ryan Hadt ◽  
Theodor Agapie
Keyword(s):  
Coordination Chemistry ◽  
Structural Changes ◽  
Information Science ◽  
Rate Increase ◽  
Design Principles ◽  
Singlet Fission ◽  
Photophysical Parameters ◽  
Novel Design ◽  
Triplet Lifetime

Singlet fission has the potential to surpass current efficiency limits in next-generation photovoltaics and to find use in quantum information science. Despite the demonstration of singlet fission in various materials, there is still a great need for fundamental design principles that allow for tuning of photophysical parameters, including the rate of fission and triplet lifetimes. Here we describe the synthesis and photophysical characterization of a novel bipentacene dipyridyl pyrrole (HDPP-Pent) and its Li- and K-coordinated derivatives. HDPP-Pent undergoes singlet fission at roughly 50% efficiency (τ<sub>SF</sub> = 730 ps), whereas coordination in the Li complex induces significant structural changes to generate a dimer, resulting in a 5-fold rate increase (τ<sub>SF</sub> = 140 ps) and near fully efficient singlet fission with virtually no sacrifice in triplet lifetime. We thus illustrate novel design principles to produce favorable singlet fission properties, wherein through-space control can be achieved via coordination chemistry-induced multi-pentacene assembly.

scholarly journals Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors

2010 ◽  
Vol 12 (3) ◽  
Author(s):  
Liat Goldshaid ◽  
Efrat Rubinstein ◽  
Alexander Brandis ◽  
Dadi Segal ◽  
Noa Leshem ◽  
...  
Keyword(s):  
Breast Tumors ◽  
Design Principles ◽  
Therapeutic Agents ◽  
Specific Targeting ◽  
Novel Design

scholarly journals Measuring, Assessing and Improving Software Quality based on Object-Oriented Design Principles

2016 ◽  
Vol 6 (1) ◽  
pp. 187-207 ◽  
Author(s):  
Reinhold Plösch ◽  
Johannes Bräuer ◽  
Christian Körner ◽  
Matthias Saft
Keyword(s):  
Object Oriented ◽  
Design Principles ◽  
Research Area ◽  
Quality Model ◽  
Design Quality ◽  
Design Assessment ◽  
Object Oriented Design ◽  
Software Product ◽  
Novel Design

AbstractGood object-oriented design is crucial for a successful software product. Metric-based approaches and the identification of design smells are established concepts for identifying design flaws and deriving design improvements thereof. Nevertheless, metrics are difficult to use for improvements as they provide only weak guidance and are difficult to interpret. Thus, this paper proposes a novel design quality model (DQM) based on fundamental object-oriented design principles and best practices. In course of discussing DQM, the paper provides a contribution in three directions: (1) it shows how to measure design principles automatically, (2) then the measuring result is used to assess the degree of fulfilling object-oriented design principles, (3) and finally design improvements of identified design flaws in object-oriented software are derived. Additionally, the paper provides an overview of the research area by explaining terms used to describe designrelated aspects and by depicting the result of a survey on the importance of object-oriented design principles. The underlying concepts of the DQM are explained before it is applied on two open-source projects in the format of a case study. The qualitative discussion of its application shows the advantages of the automated design assessment that can be used for guiding design improvements.

scholarly journals Transitions in Interface Objects: Searching Databases

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Tim Gamble ◽  
Jon May
Keyword(s):  
Contextual Information ◽  
Theoretical Models ◽  
Design Principles ◽  
Database Interface ◽  
Map Searching ◽  
Novel Design

Two experiments demonstrate that a list-like database interface which benefits from the persistence of contextual information does not show the same degree of benefit of collocating objects over display changes that has been previously observed in a map-searching study. This provides some support for the claim that the nature of the task must be taken into account in choosing how to design dynamic displays. We discuss the benefit of basing design principles on theoretical models derived from film cutting methods used in cinematography, so that they can be extended to novel design situations.

scholarly journals Controlling Singlet Fission with Coordination Chemistry-Induced Assembly of Dipyridyl Pyrrole Bipentacenes

2020 ◽  
Author(s):  
Ryan Ribson ◽  
Gyeongshin Choi ◽  
Ryan Hadt ◽  
Theodor Agapie
Keyword(s):  
Coordination Chemistry ◽  
Structural Changes ◽  
Information Science ◽  
Rate Increase ◽  
Design Principles ◽  
Singlet Fission ◽  
Photophysical Parameters ◽  
Novel Design ◽  
Triplet Lifetime

Singlet fission has the potential to surpass current efficiency limits in next-generation photovoltaics and to find use in quantum information science. Despite the demonstration of singlet fission in various materials, there is still a great need for fundamental design principles that allow for tuning of photophysical parameters, including the rate of fission and triplet lifetimes. Here we describe the synthesis and photophysical characterization of a novel bipentacene dipyridyl pyrrole (HDPP-Pent) and its Li- and K-coordinated derivatives. HDPP-Pent undergoes singlet fission at roughly 50% efficiency (τ<sub>SF</sub> = 730 ps), whereas coordination in the Li complex induces significant structural changes to generate a dimer, resulting in a 5-fold rate increase (τ<sub>SF</sub> = 140 ps) and near fully efficient singlet fission with virtually no sacrifice in triplet lifetime. We thus illustrate novel design principles to produce favorable singlet fission properties, wherein through-space control can be achieved via coordination chemistry-induced multi-pentacene assembly.

Sign in / Sign up

Export Citation Format

Share Document