Background:
The pyrazole structure is an important heterocyclic structure and plays critical
roles in agriculture, industrial and medicine. Furthermore, compounds containing pyrazole are
known to exhibit various biological properties such as antibacterial, antifungal, anticancer, antiinflammatory,
antidepressant, antipyretic, antiviral, anti-tubercular and anti-HIV activities. Because
of these properties, pyrazole molecules have become a very popular topic for organic chemists.
Methods:
A series newly substituted pyrazole molecules were synthesized and characterized. Their
antimicrobial activities were investigated by disk diffusion method against some gram positive bacteria
and gram negative bacteria.
Results:
The present results indicated that the some test compounds were active in a broad spectrum
against important human pathogenic microorganisms. The substituted pyrazoles including carbazone
(7a, b) and thiazolidine (8a, b) showed a wide variety of biological activities. The results showed
that synthesized pyrazole, compounds 7b and 8b are highly active and more potent in both biological
and molecular docking simulation studies.
Conclusion:
The synthesized pyrazole molecules showed moderate antibacterial activities against
the tested microorganism compared to antibiotic drug. Some test compounds (7b and 8b) might be
used as new antibacterial agents.
