scholarly journals Studies on Aplysia neurons suggest treatments for chronic human disorders

2012 ◽  
Vol 22 (17) ◽  
pp. R705-R711 ◽  
Author(s):  
Thomas W. Abrams
Keyword(s):  
Aplysia Neurons ◽  
Human Disorders

Insights Studies for Certain Natural FDA Approved Polyphenolics and Repurposing for COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1390-1395
Author(s):  
Arafa Musa ◽  
Ehab M. Mostafa ◽  
Mohammad M. Al-Sanea ◽  
Shaimaa R. Ahmed ◽  
Gomaa Mostafa-Hedeab ◽  
...  
Keyword(s):  
Docking Studies ◽  
Human Populations ◽  
Energy Score ◽  
Protease Enzyme ◽  
Human Disorders ◽  
Variable Chemical ◽  
Pancreatic Disorders ◽  
New Treatment ◽  
New Applications ◽  
Death Cases

Natural polyphenolic drugs were approved for treatment of various diseases. Diosmin, rutin, quercetin, aesculin, genistein, hesperidin and silybin are known for their safety and have been applied for several human disorders including cancer, cardiovascular disorders, atherosclerosis, oxidative stress, capillary fragility, liver and pancreatic disorders and others. As the structures of the selected polyphenolic compounds possess variable chemical moieties with diverse chemical and electronic characters, these properties have been employed for further insights studies to predict new applications concerning the newly occurred pandemic. COVID-19 is a terrible disease that attacked millions of human populations at the end of year 2019. As the number of death cases has increased to exceed one million of humans, the early discovery of new treatment from previously approved and safe drugs is the main target of this study. Employing the putative docking studies for the selected polyphenolic drugs were done and the results were promising, all tested drugs exhibited high affinity with the selected five proteins of protease enzyme, the docking score ranged from -8.4461 to -26.1691 kcal/mol with 3-7 variable interaction bonds. Among the tested drugs, diosmin appeared as the most promising drug as it exhibited the highest energy score and interaction bonds with the most of proteins.

Momordica balsamina L.: An Appraisal on Morphology, Ecological Diversity, Phytochemistry, Pharmacological and Biotechnological Applications

2020 ◽  
Vol 06 ◽  
Author(s):  
Saheed Sabiu ◽  
Christiana Eleojo Aruwa ◽  
Viresh Mohanlall ◽  
Himansu Baijnath
Keyword(s):  
Relevant Information ◽  
Perennial Herb ◽  
Biotechnological Applications ◽  
Tropical Regions ◽  
Toxicological Data ◽  
Human Disorders ◽  
Potential Applications ◽  
Baseline Information ◽  
The Caribbean ◽  
Bioactive Agents

Background: Momordica balsamina L. is a monoecious climbing vine and perennial herb native to the tropical regions of Asia, Arabia and the Caribbean, and with prominent presence in Nigeria, Botswana, Namibia, Swaziland and Southern African provinces. While evidence of its anecdotal usage as medicine exist, scientific reports complementing the claims are still emerging or at their infancy. Objective: This review appraised the morphology, therapeutic and biotechnological significance of M. balsamina. Method: Online resources such as Google Scholar, PubMed, ScienceDirect and MeSH were utilized for literature search and included relevant information from inception till May 2020 to streamline sought outcomes for in-depth discussion. Results: The data gathered and considered worthy of inclusion in this study revealed that M. balsamina is rich in phytonutrients of medicinal significance with cucurbitane-type triterpenoids, balsamin and momordins well characterized and fully elucidated. These compounds and other novel bioactive agents in M. balsamina have found remarkable pharmacological relevance and could further be harnessed for use against several debilitating human disorders. Conclusion: The potential applications of M. balsamina as nutraceutical and pharmaceutical agent should not be undermined. Also, with the inadequate toxicological data on this wild species, its consumption should be with caution and translational studies that could advance scientific knowledge and aid better understanding of both its pharmacokinetics and pharmacodynamics without sidelining its potent biotechnological applications are highly encouraged. It is hoped that this paper will provide baseline information that could serve as a guide and inspiration for further studies on the prospects of M. balsamina.

scholarly journals Identified Aplysia neurons form specific chemical synapses in culture

1983 ◽  
Vol 3 (12) ◽  
pp. 2614-2620 ◽  
Author(s):  
J Camardo ◽  
E Proshansky ◽  
S Schacher
Keyword(s):  
Specific Chemical ◽  
Aplysia Neurons ◽  
Chemical Synapses

Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use

2020 ◽  
Vol 318 (5) ◽  
pp. H1325-H1336
Author(s):  
Jaime Eugenín ◽  
Carolina Larraín ◽  
Patricio Zapata
Keyword(s):  
Carotid Body ◽  
Therapeutic Use ◽  
Therapeutic Effectiveness ◽  
Sympathetic Outflow ◽  
Sympathetic Hyperactivity ◽  
Functional Changes ◽  
Human Disorders ◽  
Carotid Body Denervation

Unilateral carotid body denervation has been proposed as treatment for sympathetic hyperactivity-related human disorders. Its therapeutic effectiveness for maintaining a persistent decrease in the sympathetic outflow activity will depend on the absence of compensatory chemoreflex plasticity in the remnant carotid and aortic afferents. Here, we suggest that the integrity of central afferents after carotid body denervation is essential to prevent the emergence of plastic functional changes on the contralateral “intact” carotid nerve.

scholarly journals Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Enrico Gugliandolo ◽  
Marika Cordaro ◽  
Roberta Fusco ◽  
Alessio Filippo Peritore ◽  
Rosalba Siracusa ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Inflammatory Response ◽  
Protective Effect ◽  
Underlying Mechanism ◽  
New Drugs ◽  
Ethanol Administration ◽  
Common Disease ◽  
Intragastric Administration ◽  
Human Disorders ◽  
Interest In Research

AbstractGastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gastric ulcer. The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix Aspersa Muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of ethanol intragastric administration which has been widely used to test the drugs efficacies and to explore the underlying mechanism for gastric ulcer development. The intragastric ethanol administration causes several mucosal damages and an induction of a severe inflammatory response. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on mucus content, oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer.

Symptoms and Their Relationship to Diagnosis: A Commentary on “Symptom Descriptions in Psychopathology: How Well Are They Working for Us?” (Wilshire et al., 2021)

2021 ◽  
pp. 216770262199035
Author(s):  
John B. Saunders
Keyword(s):  
Natural History ◽  
Gaming Disorder ◽  
Human Disorders ◽  
History Of ◽  
The Way

Symptoms are vital representations of human disorders, are key to understanding disorders, and may be the focus of specific therapeutic efforts. Symptoms are imperfect, and there are many influences on how they are described and understood. Are they hand servants of diagnosis or important in their own right? The answer seems to be both, but diagnosis is typically the way in which communication about psychopathology occurs internationally in many clinical disciplines. Diagnosis is also the basis of knowledge of the natural history of psychopathology and its treatment and therapy. Investigations into the nature and meaning of symptoms can helpfully focus on emerging disorders, of which gaming disorder is provided as an example.

Proteomics and metabolomics studies exploring the pathophysiology of renal dysfunction in autosomal dominant polycystic kidney disease and other ciliopathies

2019 ◽  
Vol 35 (11) ◽  
pp. 1853-1861 ◽  
Author(s):  
Miriam Zacchia ◽  
Emanuela Marchese ◽  
Elena Martina Trani ◽  
Marianna Caterino ◽  
Giovanna Capolongo ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Clinical Signs ◽  
Research Area ◽  
Clinical Proteomics ◽  
Clinical Feature ◽  
Physiological Importance ◽  
Non Invasive ◽  
Human Disorders ◽  
Autosomal Dominant Polycystic Kidney

Abstract The primary cilium (PC) was considered as a vestigial organelle with no significant physiological importance, until the discovery that PC perturbation disturbs several signalling pathways and results in the dysfunction of a variety of organs. Genetic studies have demonstrated that mutations affecting PC proteins or its anchoring structure, the basal body, underlie a class of human disorders (known as ciliopathies) characterized by a constellation of clinical signs. Further investigations have demonstrated that the PC is involved in a broad range of biological processes, in both developing and mature tissues. Kidney disease is a common clinical feature of cilia disorders, supporting the hypothesis of a crucial role of the PC in kidney homoeostasis. Clinical proteomics and metabolomics are an expanding research area. Interestingly, the application of these methodologies to the analysis of urine, a biological sample that can be collected in a non-invasive fashion and possibly in large amounts, makes these studies feasible also in patients. The present article describes the most recent proteomic and metabolomic studies exploring kidney dysfunction in the setting of ciliopathies, showing the potential of these methodologies in the elucidation of disease pathophysiology and in the discovery of biomarkers.

scholarly journals The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 146
Author(s):  
Vittoria Cammisotto ◽  
Cristina Nocella ◽  
Simona Bartimoccia ◽  
Valerio Sanguigni ◽  
Davide Francomano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Antioxidant Supplementation ◽  
Oxidative Stress Biomarkers ◽  
Increased Risk ◽  
Human Disorders ◽  
Stress Burden

Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

scholarly journals Interaction between non-coding RNAs and JNK in human disorders

2021 ◽  
Vol 138 ◽  
pp. 111497
Author(s):  
Soudeh Ghafouri-Fard ◽  
Atefe Abak ◽  
Mahdi Mohaqiq ◽  
Hamed Shoorei ◽  
Mohammad Taheri
Keyword(s):  
Human Disorders ◽  
Non Coding Rnas
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