Bisphenol A as degradation product of monomers used in resin-based dental materials

2021 ◽  
Author(s):  
Siemon De Nys ◽  
Radu Corneliu Duca ◽  
Philippe Vervliet ◽  
Adrian Covaci ◽  
Imke Boonen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Degradation Product ◽  
Dental Materials

scholarly journals Endocrine disruptors and dental materials: health implications associated with their use in Brazil

2002 ◽  
Vol 18 (2) ◽  
pp. 505-509 ◽  
Author(s):  
Antonio Jorge Molinário Coelho
Keyword(s):  
Occupational Exposure ◽  
Bisphenol A ◽  
Dental Materials ◽  
Chemical Properties ◽  
Work Force ◽  
Dental Practice ◽  
Resin Cements ◽  
Historical Trends ◽  
Contemporary Work ◽  
Force Characteristics

This study analyzes international historical trends in the use of different types of materials in dental practice. The author describes the chemical properties of their ingredients and the potential and observed adverse effects in patients and dental technicians resulting from clinical or occupational exposure to various metals like beryllium, used to produce metal alloys. The growing use of various products (resin cements, ionomer cements, aesthetic restorative materials, resins, endodontal cements, and others) based on the compound bisphenol-A, whose chemical structure is similar to that of estrogen. Considering the demographic and contemporary work force characteristics of those involved in dental practice in the Brazil, the study highlights the possible effect of the use of these materials in both male and female patients and all age strata, as well as in health professionals with occupational exposure to products containing bisphenol-A.

scholarly journals Detection of Bisphenol-A in Dental Materials by Gas Chromatography-Mass Spectrometry.

2000 ◽  
Vol 19 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Atsufumi MANABE ◽  
Shoko KANEKO ◽  
Satoshi NUMAZAWA ◽  
Kazuo ITOH ◽  
Mitsuko INOUE ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Bisphenol A ◽  
Dental Materials ◽  
Gas Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry

scholarly journals Simultaneous analysis of bisphenol A based compounds and other monomers leaching from resin-based dental materials by UHPLC-MS/MS

2017 ◽  
Vol 40 (5) ◽  
pp. 1063-1075 ◽  
Author(s):  
Eveline Putzeys ◽  
Stevan M. Cokic ◽  
Hui Chong ◽  
Mario Smet ◽  
Jeroen Vanoirbeek ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Dental Materials ◽  
Simultaneous Analysis

scholarly journals Bisphenol A in dental materials – existence, leakage and biological effects

Heliyon ◽  
2019 ◽  
Vol 5 (5) ◽  
pp. e01711 ◽  
Author(s):  
M. Löfroth ◽  
M. Ghasemimehr ◽  
A. Falk ◽  
P. Vult von Steyern
Keyword(s):  
Bisphenol A ◽  
Biological Effects ◽  
Dental Materials

scholarly journals Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

2020 ◽  
Vol 21 (16) ◽  
pp. 5761 ◽  
Author(s):  
Ilaria Cimmino ◽  
Francesca Fiory ◽  
Giuseppe Perruolo ◽  
Claudia Miele ◽  
Francesco Beguinot ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Health ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Dental Materials ◽  
Reproductive Function ◽  
Epigenetic Changes ◽  
Synthetic Compound ◽  
Male Reproductive Function ◽  
Thermal Paper

Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. BPA can contaminate food, beverage, air, and soil. It accumulates in several human tissues and organs and is potentially harmful to human health through different molecular mechanisms. Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. Finally, epigenetic changes, such as DNA methylation, histones modification, and changes in microRNAs expression contribute to BPA pathological effects. This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.

scholarly journals Perinatal Exposure to Bisphenol-A Alters Peripubertal Mammary Gland Development in Mice

Endocrinology ◽  
2005 ◽  
Vol 146 (9) ◽  
pp. 4138-4147 ◽  
Author(s):  
Monica Muñoz-de-Toro ◽  
Caroline M. Markey ◽  
Perinaaz R. Wadia ◽  
Enrique H. Luque ◽  
Beverly S. Rubin ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Dental Materials ◽  
Perinatal Exposure ◽  
Terminal End Buds ◽  
Branching Points ◽  
Food And Beverage ◽  
Estrogenic Chemicals ◽  
Gland Morphogenesis ◽  
Apoptotic Activity

Abstract Developmental exposure to estrogenic chemicals induces morphological, functional, and behavioral anomalies associated with reproduction. Humans are exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials and plastic food and beverage containers. The aim of the present study was to determine the effects of perinatal exposure to low, environmentally relevant doses of BPA [25 and 250 ng BPA/kg body weight (bw)·d] on the peripubertal development of the mammary gland. BPA exposure enhanced the mammary glands’ sensitivity to estradiol in ovariectomized CD-1 mice. In their intact 30-d-old littermates, the area and numbers of terminal end buds relative to the gland ductal area increased whereas their apoptotic activity decreased. There was a positive correlation between ductal length and the age at first proestrus; that was reduced as the BPA dose increased, suggesting that BPA exposure slows down ductal invasion of the stroma. There was also a significant increase of progesterone receptor-positive ductal epithelial cells that were localized in clusters, suggesting future branching points. Indeed, lateral branching was significantly enhanced at 4 months of age in mice exposed to 25 ng BPA /kg bw·d. In conclusion, perinatal exposure to environmentally relevant BPA doses results in persistent alterations in mammary gland morphogenesis. Of special concern is the increased terminal end bud density at puberty as well as the increased number of terminal ends reported previously in adult animals, as these two structures are the sites at which cancer arises in humans and rodents.

scholarly journals Bisphenol A and Related Compounds in Dental Materials

PEDIATRICS ◽  
2010 ◽  
Vol 126 (4) ◽  
pp. 760-768 ◽  
Author(s):  
A. F. Fleisch ◽  
P. E. Sheffield ◽  
C. Chinn ◽  
B. L. Edelstein ◽  
P. J. Landrigan
Keyword(s):  
Bisphenol A ◽  
Dental Materials ◽  
Related Compounds

scholarly journals A Systematic Review of Exposure to Bisphenol A from Dental Treatment

2019 ◽  
Vol 4 (2) ◽  
pp. 106-115 ◽  
Author(s):  
T. Marzouk ◽  
S. Sathyanarayana ◽  
A.S. Kim ◽  
A.L. Seminario ◽  
C.M. McKinney
Keyword(s):  
Systematic Review ◽  
Bisphenol A ◽  
Dental Treatment ◽  
Dental Materials ◽  
Library Science ◽  
Dental Composite ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting ◽  
Before And After ◽  
Open Question

Introduction: Dental composite restorations and dental sealants containing bisphenol A glycidyl methacrylate (BisGMA) are commonly used materials in dentistry. Bisphenol A (BPA) is used to manufacture BisGMA and can be a by-product in BisGMA-based dental materials. BPA is an endocrine-disrupting chemical that may affect reproductive, psychological, cognitive, and endocrine-related health. We conducted a systematic review of clinical studies that measured urinary BPA (uBPA) concentrations before and after dental treatment to evaluate the extent to which individuals are exposed to BPA from dental treatment. Methods: Eligibility included studies that measured uBPA concentrations before and after dental treatment with any type of resin-based dental material. We searched PubMed, Cochrane, Web of Science, Virtual Health Library, Science Direct, ProQuest, and Clinical Trials with no date or language restrictions to identify published studies. We summarized eligible studies across participant characteristics, amount of treatment, and time of follow-up measures. Because methods of measuring uBPA varied, our primary outcome was the direction and percentage change between baseline and 24 h posttreatment and at later time points as available. Results: We identified 1,190 abstracts and 7 eligible studies: 4 in children and 3 in adults. In all studies, BPA concentrations increased 24 h after treatment. The 2 studies with the largest sample sizes found statistically significant increases >40% in uBPA concentrations at 24 h posttreatment (both P values <0.01). The 1 study to examine uBPA concentrations beyond 1 mo posttreatment found that concentrations returned to baseline by 14 d after treatment and remained at baseline 6 mo after treatment. Conclusions: Our findings suggest that uBPA concentrations increase 24 h after dental treatment. One study showed that uBPA concentrations return to baseline by 14 d. Additional research is needed to determine the magnitude of change from pre– to post–dental treatment and the trajectory of uBPA concentrations posttreatment. Knowledge Transfer Statement: BPA is an endocrine-disrupting chemical that may have negative human health effects. Our findings suggest that urinary BPA concentrations increase in the short term after dental treatment. The extent to which such an increase may affect the health of patients remains an open question, particularly since there are no established thresholds for safety or harm related to BPA exposure.

scholarly journals Estrogenic Activity of Dental Materials and Bisphenol-A Related Chemicals in vitro.

2000 ◽  
Vol 19 (3) ◽  
pp. 245-262 ◽  
Author(s):  
Yoshiya HASHIMOTO ◽  
Masaaki NAKAMURA
Keyword(s):  
Bisphenol A ◽  
Estrogenic Activity ◽  
Dental Materials
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