Glycaemic control for painful diabetic peripheral neuropathy is more than fasting plasma glucose and glycated haemoglobin

Abstract Background : Use of antidepressants is seen to be a risk factor for type 2 diabetes, even though the underlying mechanisms remain unclear. We examined whether antidepressant use was associated with change in fasting plasma glucose, glycated haemoglobin (HbA1c), β-cell function (HOMA2-%B) and insulin sensitivity (HOMA2-%S) over time. Methods : Participants in the French D.E.S.I.R. cohort study included over 4700 men (48.1%) and women, free of diabetes, aged 30–65 years at baseline in 1994–96 (D.E.S.I.R. 0), who were followed for 9 years at 3-yearly intervals (D.E.S.I.R. 3, 1997–99; 6, 2000–02; 9, 2003–05). Antidepressant use, fasting plasma glucose, HbA1c, HOMA2-%B and HOMA2-%S were assessed concurrently at four medical examinations. Linear mixed models were used to examine the cross-sectional and longitudinal associations of time-dependent antidepressant use with changes in these four biological parameters. Results : Mean fasting plasma glucose and HbA1c increased whereas HOMA2-%B and HOMA2-%S decreased over the follow-up. In a fully adjusted model, there were no differences in: mean fasting plasma glucose ( β = 0.01 mmol/l, P = 0.702); HbA1c ( β = 0.01 %, P = 0.738); HOMA2-%B ( β = 0.00, P = 0.812); or HOMA2-%S ( β =−0.01, P = 0.791) at baseline (1994–96) between antidepressant users and non-users. The interaction term with time also suggested no differences in the annual change in: fasting plasma glucose ( β = 0.00 mmol/l, P = 0.322); HbA1c ( β = 0.00 %, P = 0.496); HOMA2-%B ( β = 0.00, P = 0.609); or HOMA2-%S ( β = 0.00, P = 0.332) between antidepressant users and non-users. Similar associations were observed in analyses of type and cumulative use of antidepressants over follow-up. Conclusion : Our longitudinal data show that use of antidepressants is not associated with altered glucose metabolism, suggesting that the association between antidepressant use and diabetes reported by previous studies may not be causal. Detection bias or clinical ascertainment bias may account for much of this apparent association.

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Comparison of glycated haemoglobin and fasting blood glucose in the diagnosis of diabetes mellitus and pre-diabetes in a cohort of obese patients

Journal of The Royal Naval Medical Service ◽

10.1136/jrnms-103-39 ◽

2017 ◽

Vol 103 (1) ◽

pp. 39-43

Author(s):

D M L Chan ◽

M Murphy

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Diagnostic Criteria ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycated Haemoglobin ◽

World Health ◽

Expert Committee ◽

Obese Patients ◽

Fasting Plasma

AbstractBackgroundDiabetes mellitus (DM) has historically been diagnosed by measurement of blood glucose concentrations. More recently, the use of glycated haemoglobin (HbA1c) has been advocated in the diagnosis of diabetes, complementing its existing role in the monitoring of glycaemic control.A recent study has shown that obesity is an important problem in the UK Armed Forces. Obese patients are at increased risk of diabetes and intermediate hyperglycaemia (pre-diabetes). It is unclear whether the application of diagnostic criteria based on HbA1c would produce different categorisation of obese patients compared with standard glucose-based criteria. In the current study, we compared HbA1c with fasting plasma glucose in the diagnosis of type 2 diabetes and intermediate hyperglycaemia in a cohort of obese patients.MethodsPatients were recruited from the NHS Tayside Specialist Weight Management Service. They were classified into three categories (normoglycaemia, pre-diabetes, and diabetes) according to their fasting plasma glucose (FPG) and HbA1c. The diagnostic criteria of three organisations were applied: the World Health Organisation (WHO); the American Diabetes Association (ADA); and the International Expert Committee (IEC). Glucose, insulin, cholesterol, triglycerides, uric acid, liver function tests and sex hormone-binding globulin (SHBG) were measured.ResultsBy WHO (fasting glucose) criteria, 102 subjects were classified as normal, 13 as having impaired fasting glycaemia (IFG) and 5 as having diabetes mellitus (DM). By IEC (HbA1c) criteria, 89 subjects were classified as normal, 21 as pre-diabetes and 7 as DM. By ADA (HbA1c) criteria, 69 subjects were classified as normal, 41 as pre-diabetes and 7 as DM. Alkaline phosphatase was significantly higher in hyperglycaemic states compared with normal subjects, with ANOVA F statistics of 9.45 for WHO (p < 0.001), 9.24 for IEC (p < 0.001), and 6.87 for ADA (p < 0.01).ConclusionAlthough the numbers were small, more obese patients were categorised as hyperglycaemic (pre-diabetes and diabetes) when HbA1c-based criteria were applied, compared with WHO (glucose-based) criteria. Further studies are required to confirm this preliminary observation.

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Impact of diabetes duration on achieved reductions in glycated haemoglobin, fasting plasma glucose and body weight with liraglutide treatment for up to 28 weeks: a meta‐analysis of seven phase III trials

Diabetes Obesity and Metabolism ◽

10.1111/dom.12623 ◽

2016 ◽

Vol 18 (7) ◽

pp. 721-724 ◽

Cited By ~ 4

Author(s):

J. Seufert ◽

T. Bailey ◽

S. Barkholt Christensen ◽

M. A. Nauck

Keyword(s):

Body Weight ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Meta Analysis ◽

Glycated Haemoglobin ◽

Diabetes Duration ◽

Phase Iii ◽

Fasting Plasma ◽

Phase Iii Trials

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Dietary Fibre Intake in Type 2 and New-Onset Prediabetes/Diabetes after Acute Pancreatitis: A Nested Cross-Sectional Study

Nutrients ◽

10.3390/nu13041112 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1112

Author(s):

Xinye Li ◽

Wandia Kimita ◽

Jaelim Cho ◽

Juyeon Ko ◽

Sakina H. Bharmal ◽

...

Keyword(s):

Acute Pancreatitis ◽

Glucose Metabolism ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Dietary Fibre ◽

Glycated Haemoglobin ◽

Cross Sectional Study ◽

Cross Sectional ◽

Fasting Plasma ◽

Habitual Intake

The association between intake of dietary fibre and glucose metabolism has been extensively investigated in numerous metabolic disorders. However, little is known about this association in individuals after an attack of acute pancreatitis (AP). The aim was to investigate the associations between intake of dietary fibre and markers of glucose metabolism in individuals with new-onset prediabetes or diabetes after acute pancreatitis (NODAP), pre-exiting type 2 prediabetes or diabetes, and normoglycaemia after acute pancreatitis. This cross-sectional study was nested within the parent prospective longitudinal cohort study. The studied markers of glucose metabolism were fasting plasma glucose and glycated haemoglobin. Habitual intake of dietary fibre was determined using the EPIC-Norfolk food frequency questionnaire. Multivariable linear regression analyses were conducted. The study included a total of 108 individuals after AP. In the NODAP group, increased intakes of total fibre (β = −0.154, p = 0.006), insoluble fibre (β = −0.133, p = 0.01), and soluble fibre (β = −0.13, p = 0.02) were significantly associated with a reduction in fasting plasma glucose. Increased intakes of vegetables (β = −0.069, p = 0.004) and nuts (β = −0.039, p = 0.038) were significantly associated with a reduction in fasting plasma glucose. Increased intake of nuts (β = −0.054, p = 0.001) was also significantly associated with a reduction in glycated haemoglobin. None of the above associations were significant in the other study groups. Habitual intake of dietary fibre was inversely associated with fasting plasma glucose in individuals with NODAP. Individuals after an attack of AP may benefit from increasing their intake of dietary fibre (specifically, vegetables and nuts) with a view to preventing NODAP.

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Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance

Acta Diabetologica ◽

10.1007/s00592-003-0109-8 ◽

2003 ◽

Vol 40 (4) ◽

pp. 181-186 ◽

Cited By ~ 37

Author(s):

E. Mannucci ◽

A. Ognibene ◽

I. Sposato ◽

M. Brogi ◽

G. Gallori ◽

...

Keyword(s):

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycated Haemoglobin ◽

Fasting Plasma

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Relationship between Fasting Plasma Glucose and Glycated Haemoglobin In Adult Diabetic Nigerians

African Journal of Biomedical Research ◽

10.4314/ajbr.v10i2.50614 ◽

2010 ◽

Vol 10 (2) ◽

Author(s):

O.A Akinloye ◽

O.A Adaramoye ◽

K.S Akinlade ◽

A.A Odetola ◽

A.A Raji

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycated Haemoglobin ◽

Fasting Plasma

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Relationship between glycated haemoglobin and fasting plasma glucose among diabetic out-patients at the University Teaching Hospital, Lusaka, Zambia

Tanzania Journal of Health Research ◽

10.4314/thrb.v18i3.4 ◽

2016 ◽

Vol 18 (3) ◽

Author(s):

Emmanuel M. Musenge ◽

Alexey Manankov ◽

Charles Michelo ◽

Boyd Mudenda

Keyword(s):

Teaching Hospital ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycated Haemoglobin ◽

Time Of Day ◽

T Test ◽

University Teaching ◽

Fasting Plasma ◽

The Mean ◽

The University

Background: Glycated haemoglobin (HbA1c) measurement provides an accurate result of glycaemic levels from blood drawn at any time of day without reference to prandial state. We established the relationship between HbA1c and fasting plasma glucose (FPG) in diabetic out-patients among diabetic outpatients in Lusaka, Zambia.Methods: This cross-sectional study was carried out at the University Teaching Hospital diabetic clinic, Lusaka, Zambia. A total sample of 198 consenting participants was selected randomly from diabetic out-patients between September and December 2013. A structured interview schedule was used to capture data on socio-demographics and laboratory examination results. The Pearson’s correlation coefficient, Student’s t-test and Paired Samples t-test were used for data analysis.Results: A total of 198 patients (mean age+SD= 53.19±13.32 years) were involved in the study. Majority (60.10%) of the patients were females while 39.90 per cent were males. The mean±SD of FPG of the patients slightly increased from the previous 10.75±7.78 mmo/L to the current 11.09±6.23 mmo/L (p = 0.592). The mean±SD of HbA1c of the patients was 54.77±17.12 mmol/mol. There was a statistically significant weak and moderate positive correlation between HbA1c and the previous and current FPG (r = 0.282, P = 0.001 and (r = 0.385, p = 0.001), respectively. However, there was a statistically significant but weak negative correlation between HbA1c and age (r = -0.163, p = 0.023).Conclusion: We found evidence of an association between HbA1c and FPG proposing that as the FPG levels increase, the HbA1c levels also increase in a predictable way. There is need to sensitise more especially the major stakeholders in the management of diabetes mellitus to consider FPG as an alternative in glycaemic control monitoring in the absence of HbA1c.

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