The prognostic role of body mass index on mortality amongst the middle-aged and elderly: A competing risk analysis

2014 ◽  
Vol 103 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Haleh Ghaem Maralani ◽  
Bee Choo Tai ◽  
Tien Y. Wong ◽  
E. Shyong Tai ◽  
Jialiang Li ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Risk Analysis ◽  
Body Mass ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
Prognostic Role ◽  
Middle Aged

scholarly journals A Scoring System For Predicting Hepatocellular Carcinoma Risk In Alcoholic Cirrhosis: A Competing Risk Analysis

2021 ◽  
Author(s):  
Kyunghan Lee ◽  
Gwang Hyeon Choi ◽  
Eun Sun Jang ◽  
Sook-Hyang Jeong ◽  
Jin–Wook Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Analysis ◽  
Viral Hepatitis ◽  
Validation Cohort ◽  
Alcoholic Cirrhosis ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
Hazards Model ◽  
B Virus

Abstract Background & Aims: The role of hepatocellular carcinoma (HCC) surveillance is being questioned in alcoholic cirrhosis because of the relative low HCC risk. Comorbid viral hepatitis may synergistically increase the HCC risk in alcoholic cirrhosis. This study aimed to assess the risk and predictors of HCC in patients with alcoholic cirrhosis by using competing risk analysis in an area with intermediate prevalence for hepatitis B virus.Methods: A total of 965 patients with alcoholic cirrhosis were recruited at a university-affiliated hospital in Korea and randomly assigned to either the derivation (n=643) and validation (n=322) cohort. Subdistribution hazards model of Fine and Gray was used with deaths and liver transplantation treated as competing risks. Death records were confirmed from Korean government databases. A nomogram was developed to calculate the Alcohol-associated Liver Cancer Estimation (ALICE) score.Results: Markers for viral hepatitis were positive in 21.0 % and 25.8 % of patients in derivation and validation cohort, respectively. The cumulative incidence of HCC was 13.5 and 14.9 % at 10 years for derivation and validation cohort, respectively. Age, positivity for viral hepatitis markers, alpha-fetoprotein level, and platelet count were identified as independent predictors of HCC and incorporated in the ALICE score, which discriminated low, intermediate, and high risk for HCC in alcoholic cirrhosis at the cut-off of 120 and 180. Conclusions: HCC risk can be stratified by using clinical parameters including viral markers in alcoholic cirrhosis in an area where the prevalence of viral hepatitis is substantial.

scholarly journals Assessment of the prognostic role of body mass index on breast cancer survivors: A Moroccan center experience

2022 ◽  
Vol 14 (1) ◽  
pp. 140
Author(s):  
R. Benmalek ◽  
S. Ejjebli ◽  
H. Bendahou ◽  
A. Maaroufi ◽  
A. Abouriche ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Cancer Survivors ◽  
Body Mass ◽  
Breast Cancer Survivors ◽  
Prognostic Role

Prognostic Role of Body Mass Index After Acute Myocardial Infarction

2006 ◽  
Vol 98 (11) ◽  
pp. 1556-1557
Author(s):  
Mitja Lainscak ◽  
Linn M.A. Kennedy ◽  
Ronnie Willenheimer ◽  
Stefan D. Anker
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Body Mass Index ◽  
Body Mass ◽  
Prognostic Role

scholarly journals A Novel Competing Risk Analysis Model to Determine the Role of Cervical Lordosis in Bony and Ligamentous Injuries

2018 ◽  
Vol 119 ◽  
pp. e962-e967
Author(s):  
Narayan Yoganandan ◽  
Anjishnu Banerjee ◽  
Nicholas DeVogel ◽  
Frank A. Pintar ◽  
Jamie L. Baisden
Keyword(s):  
Risk Analysis ◽  
Competing Risk ◽  
Cervical Lordosis ◽  
Competing Risk Analysis ◽  
Analysis Model

Prognostic role of body-mass index at diagnosis in gastric cancer: a systematic review and meta-analysis.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e15559-e15559
Author(s):  
Sashidhar Manthravadi ◽  
Anuj Shrestha ◽  
Sheshadri Madhusudhana
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Body Mass Index ◽  
Body Mass ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals The role of chemotherapy in patients with T1bN0M0 triple-negative breast cancer: a real-world competing risk analysis

2021 ◽  
Vol 12 (1) ◽  
pp. 10-17
Author(s):  
Tian Lan ◽  
Yunyan Lu ◽  
Hua Luo ◽  
Ouou Yang ◽  
Junling He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Analysis ◽  
Triple Negative Breast Cancer ◽  
Real World ◽  
Triple Negative ◽  
Competing Risk ◽  
Competing Risk Analysis

scholarly journals The Role of Adjuvant Chemotherapy in Metaplastic Breast Carcinoma: A Competing Risk Analysis of the SEER Database

2021 ◽  
Vol 11 ◽  
Author(s):  
Tian Lan ◽  
Yunyan Lu ◽  
Ruzhen Zheng ◽  
Xiying Shao ◽  
Hua Luo ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Risk Analysis ◽  
Selection Process ◽  
Treatment Strategies ◽  
Competing Risk ◽  
Lymph Node Status ◽  
Seer Database ◽  
Competing Risk Analysis ◽  
Metaplastic Breast Carcinoma

Purpose: Chemotherapy is the clinically recommended treatment for patients with operable metaplastic breast carcinoma (MBC); however, its impact remains controversial. This study investigated the possible role of chemotherapy in the treatment of MBC.Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify the operable MBC patients. The competing risk analysis along with the propensity score matching (PSM) method was performed to evaluate the effect of chemotherapy. Moreover, a competing risk nomogram was built to identify prognosis in patients with MBC.Results: Of the 1137 patients with MBC, 775 received chemotherapy and 362 did not receive chemotherapy. The 5-year cumulative incidence of breast cancer-specific death (BCSD) showed similar outcomes in both the Chemo and No-Chemo groups (21.1 vs. 24.3%, p = 0.57). Chemotherapy showed no apparent association with BCSD (HR, 1.07; 95% CI, 0.72–1.60; p = 0.72), even after subgroup analysis or PSM. Race, tumor size, lymph node status, and radiation were identified as the significant factors for MBC after a penalized variable selection process. In addition, a competing risk nomogram showed relatively good accuracy of prediction with a C-index of 0.766 (95% CI, 0.700–0.824).Conclusion: Our findings demonstrated that chemotherapy did not improve BCSD for operable MBC patients. Thus, it may indicate the need to reduce exposure to the current chemotherapy strategies for patients with resectable MBC. Additionally, some novel treatment strategies are required urgently to identify and target the potential biomarkers.

scholarly journals Body mass index and leptin are related to cognitive performance over 10 years in women with and without HIV infection

2021 ◽  
Author(s):  
Francesca Macaluso ◽  
Kathleen M Weber ◽  
Leah H Rubin ◽  
Elaine Dellinger ◽  
Susan Holman ◽  
...  
Keyword(s):  
Body Mass Index ◽  
New York ◽  
Body Mass ◽  
Processing Speed ◽  
Memory Performance ◽  
Middle Aged ◽  
Hiv Serostatus ◽  
Plasma Leptin ◽  
Baseline Bmi

Abstract Objective To determine whether body mass index (BMI) and leptin were longitudinally associated over 10 years with neuropsychological performance (NP) among middle-aged women with HIV (WWH) versus without HIV. Methods Women’s Interagency HIV Study (WIHS) participants (301 WWH, 113 women without HIV from Brooklyn, New York City and Chicago had baseline and 10-year BMI (kg/m2) and fasting plasma leptin levels using commercial ELISA (ng/mL); and demographically-adjusted NP T-scores (attention/working memory, executive function (EF), processing speed, memory, learning, verbal fluency, motor function, global) at 10-year follow-up. Multivariable linear regression analyses, stratified by HIV-serostatus, examined associations between BMI, leptin, and NP. Results Over 10 years, women (baseline age 39.8+/-9.2 years, 73% Black, 73% WWH) transitioned from average overweight (29.1+/-7.9 kg/m 2) to obese (30.5+/-7.9 kg/m 2) BMI. Leptin increased 11.4+/-26.4 ng/mL (p<0.0001). Higher baseline BMI and leptin predicted poorer 10-year EF among all women (BMI B=-6.97, 95%CI(-11.5, -2.45) p=0.003; leptin B=-1.90, 95%CI(-3.03, -0.76), p=0.001); higher baseline BMI predicted better memory performance (B=6.35, 95%CI(1.96, 10.7), p=0.005). Greater 10-year leptin increase predicted poorer EF (p=0.004), speed (p=0.029), verbal (p=0.021) and global (p=0.005) performance among all women, and WWH. Greater 10-year BMI increase predicted slower processing speed (p=0.043) among all women; and among WWH, poorer EF (p=0.012) and global (p=0.035) performance. Conclusions In middle-aged WIHS participants, 10-year increases in BMI and leptin were associated with poorer performance across multiple NP domains among all and WWH. Trajectories of adiposity measures over time may provide insight into the role of adipose tissue in brain health with aging.

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