scholarly journals Human leukocyte antigen (HLA)-binding epitopes dataset for the newly identified T-cell antigens of Mycobacterium immunogenum

Data in Brief ◽  
2016 ◽  
Vol 8 ◽  
pp. 1069-1071 ◽  
Author(s):  
Harish Chandra ◽  
Jagjit S. Yadav
Keyword(s):  
T Cell ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
T Cell Antigens ◽  
Hla Binding

scholarly journals A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors

2017 ◽  
Vol 292 (51) ◽  
pp. 21149-21158 ◽  
Author(s):  
Lucy C. Sullivan ◽  
Nicholas G. Walpole ◽  
Carine Farenc ◽  
Gabriella Pietra ◽  
Matthew J. W. Sum ◽  
...  
Keyword(s):  
T Cell ◽  
Human Leukocyte Antigen ◽  
T Cell Receptors ◽  
Human Leukocyte ◽  
Cell Receptors ◽  
Leukocyte Antigen

scholarly journals Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease

Immunity ◽  
2012 ◽  
Vol 37 (4) ◽  
pp. 611-621 ◽  
Author(s):  
Sophie E. Broughton ◽  
Jan Petersen ◽  
Alex Theodossis ◽  
Stephen W. Scally ◽  
Khai Lee Loh ◽  
...  
Keyword(s):  
Celiac Disease ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
T Cell Receptor ◽  
Human Leukocyte ◽  
Cell Receptor ◽  
Leukocyte Antigen ◽  
Receptor Usage ◽  
Gliadin Peptides

scholarly journals Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia: I. Analysis of risk factors and results of secondary transplants

Blood ◽  
1989 ◽  
Vol 74 (6) ◽  
pp. 2227-2236 ◽  
Author(s):  
NA Kernan ◽  
C Bordignon ◽  
G Heller ◽  
I Cunningham ◽  
H Castro-Malaspina ◽  
...  
Keyword(s):  
Risk Factors ◽  
T Cells ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
Graft Failure ◽  
Human Leukocyte ◽  
Marrow Transplant ◽  
High Dose ◽  
Leukocyte Antigen ◽  
Major Factors

Abstract Risk factors for graft failure were analyzed in 122 recipients of an allogeneic T-cell-depleted human leukocyte antigen (HLA)-identical sibling marrow transplant as treatment for leukemia. In each case pretransplant immunosuppression included 1,375 to 1,500 cGy hyperfractionated total body irradiation and cyclophosphamide (60 mg/kg/d x 2). No patient received immunosuppression prosttransplant for graft-versus-host disease (GVHD) prophylaxis. Nineteen patients in this group experienced graft failure. The major factors associated with graft failure were transplants from male donors and the age of the patient (or donor). Among male recipients of male donor-derived grafts a low dose per kilogram of nucleated cells, progenitor cells (colony forming unit-GM) and T cells was also associated with graft failure. Additional irradiation to 1,500 cGy, high dose corticosteroids posttransplant, and additional peripheral blood donor T cells did not decrease the incidence of graft failure. In addition, type of leukemia, time from diagnosis to transplant, an intact spleen, or the presence of antidonor leukocyte antibodies did not correlate with graft failure. To ensure engraftment of secondary transplants, further immunosuppression was necessary but was poorly tolerated. However, engraftment and survival could be achieved with an immunosuppressive regimen in which antithymocyte globulin and high dose methylprednisolone were administered both before and after infusions of secondary partially T- cell-depleted marrow grafts.

scholarly journals Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behçet’s Disease with Arthritis

2019 ◽  
Vol 20 (20) ◽  
pp. 5044 ◽  
Author(s):  
S. M. Shamsul Islam ◽  
Hyoun-Ah Kim ◽  
Bunsoon Choi ◽  
Ju-Yang Jung ◽  
Sung-Min Lee ◽  
...  
Keyword(s):  
T Cell ◽  
Human Leukocyte Antigen ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Human Leukocyte ◽  
Class Ii ◽  
T Cell Subsets ◽  
Healthy Controls ◽  
Leukocyte Antigen ◽  
Active Patients

It has been reported Human Leukocyte Antigen (HLA) gene polymorphism is a risk factor for the development of Behçet’s disease (BD). In this study, the association of HLA class II subtypes HLA-DP, DQ, DR, and T cell subsets in BD patients with arthritis was evaluated. Frequencies of HLA-DP, DQ, DR positive cells, and T cell subsets in peripheral blood leukocytes (PBL) were measured by flow cytometric analysis in BD, and compared to rheumatoid arthritis as disease controls and healthy controls. Frequencies of HLA-DQ were significantly decreased in whole PBL and granulocytes of BD active patients as compared to healthy controls. In monocytes populations, proportions of HLA-DR positive cells were significantly increased in BD active patients as compared to healthy controls. Proportions of CD4+CCR7+ and CD8+CCR7+ cells were significantly higher in BD active patients than in BD inactive in whole PBL. Frequencies of CD4+CD62L- and CD8+CD62L- cells in lymphocytes were significantly decreased in active BD than those in inactive BD. There were also correlations between disease activity markers and T cell subsets. Our results revealed HLA-DP, DQ, and DR expressing cell frequencies and several T cell subsets were significantly correlated with BD arthritis symptoms.

scholarly journals Human Leukocyte Antigen Concordance and the Transmission Risk via Breast‐Feeding of Human T Cell Lymphotropic Virus Type I

2006 ◽  
Vol 193 (2) ◽  
pp. 277-282 ◽  
Author(s):  
Robert J. Biggar ◽  
Jennifer Ng ◽  
Norma Kim ◽  
Michie Hisada ◽  
Hong‐Chuan Li ◽  
...  
Keyword(s):  
T Cell ◽  
Human Leukocyte Antigen ◽  
Breast Feeding ◽  
Virus Type ◽  
Human Leukocyte ◽  
Transmission Risk ◽  
Type I ◽  
Leukocyte Antigen ◽  
Human T Cell

scholarly journals CD8+ T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types

EBioMedicine ◽  
2015 ◽  
Vol 2 (1) ◽  
pp. 46-58 ◽  
Author(s):  
Stephen A. Migueles ◽  
Daniel Mendoza ◽  
Matthew G. Zimmerman ◽  
Kelly M. Martins ◽  
Sushila A. Toulmin ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Cd8 T Cell ◽  
Leukocyte Antigen ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma

Blood ◽  
2011 ◽  
Vol 117 (3) ◽  
pp. 788-797 ◽  
Author(s):  
Aaron P. Rapoport ◽  
Nicole A. Aqui ◽  
Edward A. Stadtmauer ◽  
Dan T. Vogl ◽  
Hong-Bin Fang ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
Conjugate Vaccine ◽  
Tumor Antigen ◽  
Pneumococcal Conjugate Vaccine ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Cell Counts ◽  
Antigen Vaccine

AbstractIn a phase 1/2 two-arm trial, 54 patients with myeloma received autografts followed by ex vivo anti-CD3/anti-CD28 costimulated autologous T cells at day 2 after transplantation. Study patients positive for human leukocyte antigen A2 (arm A, n = 28) also received pneumococcal conjugate vaccine immunizations before and after transplantation and a multipeptide tumor antigen vaccine derived from the human telomerase reverse transcriptase and the antiapoptotic protein survivin. Patients negative for human leukocyte antigen A2 (arm B, n = 26) received the pneumococcal conjugate vaccine only. Patients exhibited robust T-cell recoveries by day 14 with supraphysiologic T-cell counts accompanied by a sustained reduction in regulatory T cells. The median event-free survival (EFS) for all patients is 20 months (95% confidence interval, 14.6-24.7 months); the projected 3-year overall survival is 83%. A subset of patients in arm A (36%) developed immune responses to the tumor antigen vaccine by tetramer assays, but this cohort did not exhibit better EFS. Higher posttransplantation CD4+ T-cell counts and a lower percentage of FOXP3+ T cells were associated with improved EFS. Patients exhibited accelerated polyclonal immunoglobulin recovery compared with patients without T-cell transfers. Adoptive transfer of tumor antigen vaccine-primed and costimulated T cells leads to augmented and accelerated cellular and humoral immune reconstitution, including antitumor immunity, after autologous stem cell transplantation for myeloma. This study was registered at www.clinicaltrials.gov as NCT00499577.

scholarly journals A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression.

1978 ◽  
Vol 147 (1) ◽  
pp. 137-146 ◽  
Author(s):  
E G Engleman ◽  
A J McMichael ◽  
M E Batey ◽  
H O McDevitt
Keyword(s):  
T Cells ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
Gamma Irradiation ◽  
Mixed Lymphocyte Reaction ◽  
Suppressor Cells ◽  
Human Leukocyte ◽  
Multiparous Woman ◽  
Leukocyte Antigen ◽  
Suppressor T Cell

It has previously been shown that J.H., a human leukocyte antigen (HLA)-Dw2 homozygous multiparous woman, fails to respond in a mixed lymphocyte reaction (MLR) to her Dw1 homozygous husband W.H., and that her T cells suppress the responses of HLA matched responders to W.H. The present studies take advantage of the observation that J.H. suppressor cells resist a dose of gamma-irradiation which functionally eliminates her MLR responder cells. J.H. cells, depleted of alloreactive cells, suppress the responses of Dw2 heterozygous or homozygous cells to W.H., regardless of their associated HLA-A or B antigens. Only when W.H. or a few other cells are present as the irradiated stimulator is J.H. suppression of Dw2 responses detected. Thus, the J.H. suppressor T cell recognizes determinants in the irradiated stimulator cells as well as D locus products in the responder.

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