Peroxisome proliferator-activated receptor (PPAR) expression in cultured bovine endometrial cells and response to omega-3 fatty acid, growth hormone and agonist stimulation in relation to series 2 prostaglandin production

2006 ◽  
Vol 30 (3) ◽  
pp. 155-169 ◽  
Author(s):  
Leslie A. MacLaren ◽  
Aydin Guzeloglu ◽  
Frank Michel ◽  
William W. Thatcher
Keyword(s):  
Growth Hormone ◽  
Fatty Acid ◽  
Peroxisome Proliferator ◽  
Omega 3 ◽  
Acid Growth ◽  
Peroxisome Proliferator Activated Receptor ◽  
Endometrial Cells ◽  
Omega 3 Fatty Acid ◽  
Prostaglandin Production ◽  
Agonist Stimulation

scholarly journals Synthesis of DHA (omega-3 fatty acid): FADS2 gene polymorphisms and regulation by PPARα

OCL ◽  
2021 ◽  
Vol 28 ◽  
pp. 43
Author(s):  
Didier Majou
Keyword(s):  
Fatty Acid ◽  
Mapk Pathway ◽  
Promoter Polymorphism ◽  
Peroxisome Proliferator ◽  
Dependent Manner ◽  
Omega 3 ◽  
Peroxisome Proliferator Activated Receptor ◽  
Omega 3 Fatty Acid ◽  
Peroxisome Proliferator Response Element ◽  
Δ6 Desaturase

In humans, in several biological systems, in particular the nervous system, the FADS2 gene transcribes Δ6-desaturase, which is the rate-limiting enzyme for converting α-linolenic acid into docosahexaenoic acid (an n-3 fatty acid). The peroxisome proliferator-activated receptor α (PPARα) modulates the transcription of FADS2 gene by interacting with a second transcription factor: the retinoid X receptor α (RXRα). These transcription factors take the form of a PPARα-RXRα heterodimer and are modulated by the ligands that modify their respective structures and enable them to bind to the peroxisome proliferator response element (PPRE) located in the promoter region of the FADS2 gene. Free estradiol induces the activation of PPARα via two pathways (i) transcription through genomic action mediated by an estrogen receptor; (ii) a non-genomic effect that allows for phosphorylation and activates PPARα via the ERK1/2-MAPK pathway. Phosphorylation is an on/off switch for PPARα transcription activity. Since Δ6-desaturase expression is retro-inhibited by free intracellular DHA in a dose-dependent manner, this position paper proposes an original hypothesis: if DHA simultaneously binds to both phosphorylated PPARα and RXRα, the resulting DHA-PPARαP-RXRα-DHA heterodimer represses FADS2 gene via PPRE. The retinoic acids-RARα-RXRα-DHA heterodimer would not dissociate from corepressors and would prevent coactivators from binding to FADS2. We speculate that SNPs, which are mostly located on PPRE, modulate the binding affinities of DHA-PPARαP-RXRα-DHA heterodimer to PPRE. The DHA-PPARαP-RXRα-DHA heterodimer’s greater affinity for PPRE results in a decreased production of D6D and DHA. FADS2 promoter polymorphism would increase the competition between DHA and other ligands, in accordance with their concentrations and affinities.

Effects of the Omega-6/Omega-3 Fatty Acid Ratios and of Enterolactone on Dairy Cow Endometrial Cells.

2012 ◽  
Vol 87 (Suppl_1) ◽  
pp. 338-338
Author(s):  
Marie-France Palin ◽  
Catherine Hallé ◽  
Alan K. Goff ◽  
Hélène V. Petit ◽  
Richard Blouin
Keyword(s):  
Fatty Acid ◽  
Dairy Cow ◽  
Omega 3 ◽  
Endometrial Cells ◽  
Omega 3 Fatty Acid ◽  
Omega 6

A Consumer’s Guide to Eggs

EDIS ◽  
2013 ◽  
Vol 2013 (11) ◽  
Author(s):  
Jeanine Beatty ◽  
Karla Shelnutt ◽  
Gail P. A. Kauwell
Keyword(s):  
United States ◽  
Fatty Acid ◽  
New World ◽  
The United States ◽  
Omega 3 ◽  
Bottom Line ◽  
Christopher Columbus ◽  
Food Stores ◽  
Omega 3 Fatty Acid ◽  
Chicken Eggs

People have been eating eggs for centuries. Records as far back as 1400 BC show that the Chinese and Egyptians raised birds for their eggs. The first domesticated birds to reach the Americas arrived in 1493 on Christopher Columbus' second voyage to the New World. Most food stores in the United States offer many varieties of chicken eggs to choose from — white, brown, organic, cage free, vegetarian, omega-3 fatty acid enriched, and more. The bottom line is that buying eggs is not as simple as it used to be because more choices exist today. This 4-page fact sheet will help you understand the choices you have as a consumer, so you can determine which variety of egg suits you and your family best. Written by Jeanine Beatty, Karla Shelnutt, and Gail Kauwell, and published by the UF Department of Family Youth and Community Sciences, November 2013. http://edis.ifas.ufl.edu/fy1357

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