scholarly journals PepTherDia: database and structural composition analysis of approved peptide therapeutics and diagnostics

Author(s):  
Vera D’Aloisio ◽  
Paolo Dognini ◽  
Gillian A. Hutcheon ◽  
Christopher R. Coxon
Author(s):  
Flyndon Mark S. Dagalea ◽  
Karina Milagros R. Cui – Lim

Abstract: Kappa-carrageenan, a natural polymer that is a product derived from seaweeds has been gaining vast attention on researches because of its biodegradability and low cost production. On the side, Nanotechnology, the emerging Science of nanoparticles has been indulging the world with its new approaches on improving the characteristics of the medium used. This study differentiated the physicochemical properties of the films without and with the incorporation of zinc oxide nanoparticles (ZnOnps) to kappa-carrageenan (kc). Materials and Methods: Incorporation of ZnOnps to kc was prepared, the physicochemical properties: moisture content, degradation time, structural composition, and surface morphology were differentiated between bio composite films with and without the ZnO nps. Results and Conclusion: After several tests, zinc oxide nano particles incorporated to kappa-carrageenan exhibited some changes to its physicochemical properties, that is the lowering of moisture content and longer degradation time was observed; using SEM magnifications ZnOnps was seen in the surface of the biocomposite film. However, structural composition analysis showed that no new formation of the functional group was seen. The biocomposite films could be a substitute with the existing drug capsule because of its longer decomposition, low water content and secured safety of the drug's quality.


2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Dongxue Zhang ◽  
Wenyan Liu ◽  
Li Peng ◽  
Haiyan Wang ◽  
Mei Lin ◽  
...  

Abstract Background To investigate the difference in the structural composition of salivary flora between chronic periodontitis patients with and without diabetic nephropathy (DN). Methods Thirty salivary samples of 15 chronic periodontitis patients with DN (DN group) and 15 chronic periodontitis patients with diabetes but without DN (DM group) were subjected to pyrosequencing of polymerase chain reaction-amplified 16 s ribosomal RNA genes. After diversity testing, the differential flora were analyzed. The sequencing results were compared with GenBank database to determine the type of differential flora using species composition analysis, hierarchical cluster analysis, principal co-ordinate analysis, and species difference analysis. Results There were significant between-group differences with respect to Gemella, Selenomonas spp, Lactobacillales_unclassified, Bacteria-unclassified and Abiotrophia (p < 0.05). Compared with DM group, the relative abundance of Selenomonas spp. in DN group was significantly higher; the area under the receiver operating characteristic curve of Selenomonas spp. was 0.713 (P < 0.05). Multi-level biological identification and feature maps indicated that Selenomonas spp. might be used as a potential biomarker for DN patients. On binary logistic regression analysis, increase of Selenomonas spp. was related with DN. Conclusions We found significant between-group differences in the structural composition of oral flora. The increase in the relative abundance of Selenomonas spp. may be associated with DN in patients with chronic periodontitis.


2019 ◽  
Vol 2 (1) ◽  
pp. 8-12
Author(s):  
Angela Hartati ◽  
Diah Indriani Widiputri ◽  
Arbi Dimyati

This research was conducted for the purpose to overcome Indonesia waste problem. The samples are classified into garden waste, paper waste, wood, food waste, and MSW with objective to identify which type of waste give out more syngas since there is waste separation in Indonesia. All samples were treated by plasma gasification without pre-treatment (drying). Arc plasma torch used in this experiment was made by National Nuclear Energy Agency (BATAN) and used Argon as the gas source. Then the torch was connected to self-designed gasification chamber and gas washing system before injected into a gas bas for composition analysis. Another objective is to identify factors that may affect the gasification efficiency and the experiment shows that moisture content is not really affecting the efficiency but the duration of the process. The mass reduction of each samples were recorded, then the gas produced from the gasification process were analyzed. The result shows that food has the highest mass percentage reduced and producing the highest amount of hydrogen amongst other samples. However, treating MSW also produce considerably high amount of hydrogen. In conclusion, MSW direct treatment (without separation) using plasma gasification is feasible since it still produces desirable quality of syngas.


Author(s):  
R. Jodl ◽  
F. KrülI

AbstractThe present paper shows and discusses microphotographs of the structural composition of reconstituted tobacco sheet. So far as the biological activity of the sheets' smoke condensate had been investigated (5), the authors try to find a relation between the said activity and the microscopic structure.


2015 ◽  
Author(s):  
Ryan D. Murphy ◽  
David J. Saiz ◽  
Alvaro Augusto Cruz-Cabrera ◽  
Phil R. Aragon ◽  
Mark A. Rodriguez ◽  
...  

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