scholarly journals Urinary cadmium in relation to bone damage: Cadmium exposure threshold dose and health-based guidance value estimation

2021 ◽  
Vol 226 ◽  
pp. 112824
Author(s):  
Ying Qing ◽  
Jiaqi Yang ◽  
Yanfeng Chen ◽  
Chengjie Shi ◽  
Qianrong Zhang ◽  
...  
Keyword(s):  
Cadmium Exposure ◽  
Threshold Dose ◽  
Urinary Cadmium ◽  
Bone Damage ◽  
Value Estimation

Changes of Renal Cadmium Accumulation Levels and Urinary Cadmium Excretion Levels Induced by Long-term Cadmium Exposure in Rats

1997 ◽  
Vol 9 (1) ◽  
pp. 109
Author(s):  
In Soon Song ◽  
Yong Chae Cho ◽  
Soo Young Kim ◽  
Am Park ◽  
Kyung Sun Son ◽  
...  
Keyword(s):  
Cadmium Accumulation ◽  
Cadmium Exposure ◽  
Urinary Cadmium

Variance and covariance heterogeneity analysis for detection of metabolites associated with cadmium exposure

2014 ◽  
Vol 13 (2) ◽  
Author(s):  
Beatriz Valcarcel Salamanca ◽  
Timothy M.D. Ebbels ◽  
Maria De Iorio
Keyword(s):  
Hierarchical Models ◽  
Urinary Metabolites ◽  
Potential Effect ◽  
Environmental Pollutant ◽  
Cadmium Exposure ◽  
Urinary Cadmium ◽  
Bayesian Hierarchical ◽  
Metabolic Traits ◽  
Statistical Framework ◽  
Heterogeneity Analysis

AbstractIn this study, we propose a novel statistical framework for detecting progressive changes in molecular traits as response to a pathogenic stimulus. In particular, we propose to employ Bayesian hierarchical models to analyse changes in mean level, variance and correlation of metabolic traits in relation to covariates. To illustrate our approach we investigate changes in urinary metabolic traits in response to cadmium exposure, a toxic environmental pollutant. With the application of the proposed approach, previously unreported variations in the metabolism of urinary metabolites in relation to urinary cadmium were identified. Our analysis highlights the potential effect of urinary cadmium on the variance and correlation of a number of metabolites involved in the metabolism of choline as well as changes in urinary alanine. The results illustrate the potential of the proposed approach to investigate the gradual effect of pathogenic stimulus in molecular traits.

Low-level cadmium exposure in Toyama City and its surroundings in Toyama prefecture, Japan, with references to possible contribution of shellfish intake to increase urinary cadmium levels

2006 ◽  
Vol 362 (1-3) ◽  
pp. 56-67 ◽  
Author(s):  
T. Yamagami ◽  
T. Ezaki ◽  
J. Moriguchi ◽  
Y. Fukui ◽  
S. Okamoto ◽  
...  
Keyword(s):  
Cadmium Exposure ◽  
Urinary Cadmium ◽  
Low Level

A longitudinal study on urinary cadmium and renal tubular protein excretion of nickel–cadmium battery workers after cessation of cadmium exposure

2016 ◽  
Vol 89 (7) ◽  
pp. 1137-1145 ◽  
Author(s):  
Yanhua Gao ◽  
Yanfang Zhang ◽  
Juan Yi ◽  
Jinpeng Zhou ◽  
Xianqing Huang ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Cadmium Exposure ◽  
Urinary Cadmium ◽  
Protein Excretion ◽  
Renal Tubular ◽  
Battery Workers ◽  
Nickel Cadmium

scholarly journals The association between urinary kidney injury molecule 1 and urinary cadmium in elderly during long-term, low-dose cadmium exposure: a pilot study

2011 ◽  
Vol 10 (1) ◽  
Author(s):  
Valérie Pennemans ◽  
Liesbeth M De Winter ◽  
Elke Munters ◽  
Tim S Nawrot ◽  
Emmy Van Kerkhove ◽  
...  
Keyword(s):  
Pilot Study ◽  
Low Dose ◽  
Kidney Injury ◽  
Cadmium Exposure ◽  
Urinary Cadmium ◽  
Kidney Injury Molecule 1

scholarly journals Associations of Prenatal Exposure to Cadmium With Child Growth, Obesity, and Cardiometabolic Traits

2018 ◽  
Vol 188 (1) ◽  
pp. 141-150 ◽  
Author(s):  
Leda Chatzi ◽  
Despo Ierodiakonou ◽  
Katerina Margetaki ◽  
Marina Vafeiadi ◽  
Georgia Chalkiadaki ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Maternal Smoking ◽  
Cadmium Concentration ◽  
Standard Deviation Score ◽  
Child Growth ◽  
Cadmium Exposure ◽  
Study Cohort ◽  
Urinary Cadmium ◽  
The Impact ◽  
Cardiometabolic Traits

Abstract Prenatal cadmium exposure has been associated with impaired fetal growth; much less is known about the impact during later childhood on growth and cardiometabolic traits. To elucidate the associations of prenatal cadmium exposure with child growth, adiposity, and cardiometabolic traits in 515 mother-child pairs in the Rhea Mother-Child Study cohort (Heraklion, Greece, 2007–2012), we measured urinary cadmium concentrations during early pregnancy and assessed their associations with repeated weight and height measurements (taken from birth through childhood), waist circumference, skinfold thickness, blood pressure, and serum lipid, leptin, and C-reactive protein levels at age 4 years. Adjusted linear, Poisson, and mixed-effects regression models were used, with interaction terms for child sex and maternal smoking added. Elevated prenatal cadmium levels (third tertile of urinary cadmium concentration (0.571–2.658 μg/L) vs. first (0.058–0.314 μg/L) and second (0.315–0.570 μg/L) tertiles combined) were significantly associated with a slower weight trajectory (per standard deviation score) in all children (β = −0.17, 95% confidence interval (CI): −0.32, −0.02) and a slower height trajectory in girls (β = −0.30, 95% CI: −0.52,−0.09; P for interaction = 0.025) and in children born to mothers who smoked during pregnancy (β = −0.48, 95% CI: −0.83, −1.13; P for interaction = 0.027). We concluded that prenatal cadmium exposure was associated with delayed growth in early childhood. Further research is needed to understand cadmium-related sex differences and the role of coexposure to maternal smoking during early pregnancy.

scholarly journals Urinary cadmium concentration and the risk of ischemic stroke

Neurology ◽  
2018 ◽  
Vol 91 (4) ◽  
pp. e382-e391 ◽  
Author(s):  
Cheng Chen ◽  
Pengcheng Xun ◽  
Cari Tsinovoi ◽  
Leslie A. McClure ◽  
John Brockman ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Racial Differences ◽  
Cadmium Concentration ◽  
Serum Zinc ◽  
Cox Proportional Hazards ◽  
Cadmium Exposure ◽  
Urinary Cadmium ◽  
Never Smokers ◽  
Incident Cases ◽  
Urinary Cadmium Concentration

ObjectivesTo examine the association between urinary cadmium levels and the incidence of ischemic stroke and to explore possible effect modifications.MethodsA case-cohort study was designed nested in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, including 680 adjudicated incident cases of ischemic stroke and 2,540 participants in a randomly selected subcohort. Urinary creatinine–corrected cadmium concentration was measured at baseline. Multivariable-adjusted hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated with the Barlow weighting method for the Cox proportional hazards regression model.ResultsThe median urinary cadmium concentration was 0.42 (interquartile range 0.27–0.68) μg/g creatinine. After adjustment for potential confounders, urinary cadmium was associated with increased incidence of ischemic stroke (quintile 5 vs quintile 1: HR 1.50, 95% CI 1.01–2.22, p for trend = 0.02). The observed association was more pronounced among participants in the lowest serum zinc tertile (tertile 3 vs tertile 1: HR 1.82, 95% CI 1.06–3.11, p for trend = 0.004, p for interaction = 0.05) but was attenuated and became nonsignificant among never smokers (tertile 3 vs tertile 1: never smokers: HR 1.27, 95% CI 0.80–2.03, p for trend = 0.29; ever smokers: HR 1.60, 95% CI 1.06–2.43, p for trend = 0.07, p for interaction = 0.51).ConclusionsFindings from this study suggest that cadmium exposure may be an independent risk factor for ischemic stroke in the US general population. Never smoking and maintaining a high serum zinc level may ameliorate the potential adverse effects of cadmium exposure.

Abstract P249: Urinary Cadmium and Cardiovascular Health: Findings from the Survey of the Health of Wisconsin

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Kristen M Malecki ◽  
F. Javier Nieto
Keyword(s):  
Linear Regression ◽  
Cardiovascular Health ◽  
Family Income ◽  
Vegetable Consumption ◽  
Geometric Mean ◽  
Population Based ◽  
Dietary Factors ◽  
Cadmium Exposure ◽  
Population Exposure ◽  
Urinary Cadmium

Mounting evidence in both human and animal studies suggest cadmium exposure increases the risk for cardiovascular disease morbidity and mortality. Recent evidence have found associations between cadmium exposures and mortality in the general US population, however, studies of incident CVD events have been mixed. Consequently, there is a need to better understand determinants of variations in cadmium exposure and the association of current population exposure levels with cardiovascular risk factors in diverse population-based studies. Data from a sub-sample of 300 participants from the 2008-11 waves of the Survey of the Health of Wisconsin (SHOW) were used to study the association between urinary cadmium levels and cardiovascular health. SHOW is based on a probabilistic statewide sample of adult (21-74 years old) residents of the state of Wisconsin. Good cardiovascular health (CVH) was defined as recommended by the American Heart Association, using a combination of “ideal or intermediate” levels of seven factors and health behaviors (body mass index, cholesterol, glucose, diet, physical activity, blood pressure and smoking). Associations of log-linear estimates of creatinine-adjusted cadmium levels (ug/g creatinine) and CVH were examined using logistic and linear regression models. Covariates included individual-level demographics (race/ethnicity and gender), SES (median family income and education), smoking status (current or former vs. non), and diet (fruits and vegetable consumption). Urinary cadmium levels (ug/g creatine) were statistically higher than comparable national estimates among women (geometric mean = .36;95% CI =.30-.44) and populations living 200% above federal poverty estimates (geometric mean =.32; 95% CI .28-.38). Higher cadmium levels were associated with good CVH (OR 1.4; 1.06-1.90). Using linear regression log-cadmium levels were inversely associated with BMI (ß=-1.04; p-value=.002) after adjustment for sociodemographic, smoking and dietary factors. Stratified analyses found associations held among non-smokers but not current or former. Cadmium was not associated with any other individual CVH factors. Paradoxically, findings suggest that urinary cadmium levels, a marker of chronic cadmium exposure, are associated with high SES, lower levels of BMI and good cardiovascular health in this population based sample, further exploration and long-term follow-up are warranted.

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