Managing postmenopausal bleeding revisited: what is the best first line investigation and who should be seen within 2 weeks? A cross-sectional study of 326 women

Author(s):  
Ayman A.A. Ewies ◽  
Patrick Musonda
2011 ◽  
Vol 8 (1) ◽  
pp. 33 ◽  
Author(s):  
Eric Pefura Yone ◽  
Awa Betyoumin ◽  
André Kengne ◽  
François Kaze Folefack ◽  
Jeanne Ngogang

2016 ◽  
Vol 174 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Gabriel Etienne ◽  
Francoise Huguet ◽  
Agnès Guerci-Bresler ◽  
Franck E. Nicolini ◽  
Frédéric Maloisel ◽  
...  

2020 ◽  
Vol 3 (1) ◽  

Introduction: Highly active antiretroviral therapy (HAART) played a critical role in the medical management of HIV infected individuals by restoring the immune function and minimizes HIV related outcomes. But treatment failure minimized these advantages and leads to an increment of morbidity and mortality with poor quality of life in all HIV patients. The aim at this study was to assess the prevalence of HIV-1 treatment failure and its determinants factors among children on first line HAART at Felegehiwot Referral Hospital. Methods: Cross sectional study was conducted on 238 children who had on first line HAART regimen using the inclusion criteria. Data were collected from patients’ chart starting from ART commencement (baseline data and other information) and interviewed using structured questionnaire. CD4 T-cells from whole blood and viral load from separated plasma were analyzed according to protocols. The collected data were analyzed using SPSS packages version 20. Descriptive statistics, odds ratio, bi-variate and multiple logistic regression analysis were used to show determinant factors association. Independent associations were considered with p<0.05. Result: Among the 238 participants enrolled, 137(57.6%) were females. The mean ages were 8.09 years and the median months on HAART from initiation were 51.93 months. A total of 25 (10.5%) participants were found to have virologic/treatment failure. The mean CD4 T-cells at base line were 342.33 cells/ml and 672.13 cells/ml respectively. Long duration on treatment, sub-optimal drug adherence, conducting faith healing, high medication dosage and ambulatory functional status at baseline were found to be significant predictors of treatment failure and showed positive odds ratio. Conclusion: This study demonstrates high virologic failure and the determinant factors of virologic failures among HAART first line children are still changing. Therefore, evidence-based intervention and early detection of treatment failure must be made to further identify the potential causes and set standardized protective mechanisms of virologic failures.


2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Bushra Haq ◽  
Humaira Akram ◽  
Tabinda Rana

Objectives: To find out causative factors of adolescent menorrhagia and success of various treatments. Design: Descriptive cross sectional study Place & duration of study: Lady Willingdon Hospital, Lahore from May 2004 to April 2005. Subject and methods: Fifty unmarried patients at 12-19 years with menorrhagia selected by non-probability convenience sampling. Blood loss was determined by duration of bleeding extending beyond seven days, passage of clots and presence of anaemia. Results: The most common cause of menorrhagia was DUB (92%) followed by bleeding and endocrinal disorder. Non-steroidal anti-inflammatory drug and antifibrinolytic agent produced 75% subjective improvement in complaints. However, combined oral contraceptive produced 66% improvement. Conclusion: NSAIDS and antifibrinolytic drugs were found to be effective in reducing menstrual loss and should be used as first line of treatment.


2020 ◽  
Vol 40 (4) ◽  
pp. 625-635 ◽  
Author(s):  
Yu-xin Zhan ◽  
Shi-yu Zhao ◽  
Jiao Yuan ◽  
Huan Liu ◽  
Yun-fang Liu ◽  
...  

2016 ◽  
Vol 46 (1) ◽  
pp. 32
Author(s):  
Andy Setiawan ◽  
Idham Amir ◽  
Alan R. Tumbelaka

Background Sepsis and meningitis are major causes of mortalityand morbidity in neonates. The prevalence of sepsis is around 1-4out of every 1000 live births, and one-fourth is accompanied bymeningitis. These numbers are higher in prematures.Objective To find out the prevalence and etiological patterns ofbacterial meningitis in neonatal sepsis, and the pattern of antibi-otic susceptibility for organisms causing bacterial meningitis.Methods This was a cross sectional study, conducted in the neo-natal ward and emergency room at Cipto Mangunkusumo Hospi-tal from October 2003 to October 2004.Results Seventy two neonates fulfilled the inclusion criteria andwere examined for blood and cerebrospinal fluid (CSF) cultures.Sixty out of 72 neonates were proven for sepsis. Bacterial menin-gitis was found in 18 neonates, and all cases were accompaniedby sepsis. Positive CSF cultures were found in 12 neonates. Theother six were diagnosed based on CSF cell count >32/μl.Acinetobacter calcoaceticus was the major causative organismsin this study. The organisms were highly resistant to first line anti-biotics, except for chloramphenicol. They were also sensitive toceftazidime (second line), meropenem, and imipenem.Conclusions The prevalence of bacterial meningitis in neonatalsepsis at Cipto Mangunkusumo Hospital was 18/60 in 2003-2004.The major causative organism was Acinetobacter calcoaceticus.Antibiotic resistance was very high and only chloramphenicol,ceftazidime, meropenem, and imipenem remain effective


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