scholarly journals Medical Decision-Making Incapacity among Newly Diagnosed Older Patients with Hematological Malignancy Receiving First Line Chemotherapy: A Cross-Sectional Study of Patients and Physicians

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0136163 ◽  
Author(s):  
Koji Sugano ◽  
Toru Okuyama ◽  
Shinsuke Iida ◽  
Hirokazu Komatsu ◽  
Takashi Ishida ◽  
...  
Keyword(s):  
Older Patients ◽  
Medical Decision Making ◽  
Hematological Malignancy ◽  
Cross Sectional Study ◽  
Medical Decision ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
First Line ◽  
Cross Sectional ◽  
Line Chemotherapy

scholarly journals EVALUATION OF IMPROVEMENT IN RENAL FUNCTION AFTER FIRST-LINE CHEMOTHERAPY IN MULTIPLE MYELOMA PATIENTS PRESENTING WITH RENAL IMPAIRMENT

2021 ◽  
Vol 71 (4) ◽  
pp. 1431-35
Author(s):  
Syed Abdul Mannan Hamdani ◽  
Abdul Wahab ◽  
Musa Azhar ◽  
Faiza Iftikhar ◽  
Bushra Ahsan ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Renal Function ◽  
Renal Impairment ◽  
Serum Creatinine ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
First Line ◽  
Cross Sectional ◽  
Kaplan Meier ◽  
Line Chemotherapy

Objective: To evaluate the effect of response to first-line chemotherapy on renal functions in multiple myeloma (MM) patients. Study Design: Cross-sectional study. Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital, Lahore, from Jan 2013 to Dec 2017. Methodology: Multiple myeloma patients with renal impairment (RI) at baseline were included. Data was collected from the hospital registry.The variables assessed pre and post first-line chemotherapywere age, gender, initial estimated glomerular filteration rate and serum creatinine levels. Progression-free survivaland overall survival (OS) was calculated for both groups of patients i.e those who had improvement in renal funtions and those who did not show improvement. Kaplan-Meier curves were drawn, and SPSS-20 was used for data analysis. Results: Mean age was 48 ± 7 years. Out of 139 myeloma patients, 35 (25.1%) had RI at baseline. Males were 23 (65.7%), while females were 12 (34.3%). Cyclophosphamide, thalidomide and deamethsone (CTD)were used in the majority 30 (85.7%) followed by boretzomib, thalidomide and dexamethasone (VTD) in 2 (5.7%) patients. Boretezomib and dexamethasone (BorDex), lenalidomide and dexamethasone (Len Dex), lenalidomde, cyclophosphamide and dexamethasone (LCD) were given to 1 (2.8%) patient each. Serum creatinine levels normalized in 19 (54.3%). Dialysis was required in 11 (31.4%) patients out of which 3 (8.6%) got dialysis-independent while 8 (22.9%) patients remained dialysis-dependent. The medianoverall survival in whomcreatinine levels normalized was 35 months while it was 15 months in those in whom it did not normalize. Conclusion: Prompt administration of chemotherapy regimens can lead to an improvement in renal function....................

scholarly journals Prevalence and determinants of potentially inappropriate medication use in Hong Kong older patients: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e051527
Author(s):  
Huanyu Zhang ◽  
Eliza LY Wong ◽  
Samuel YS Wong ◽  
Patsy YK Chau ◽  
Benjamin HK Yip ◽  
...  
Keyword(s):  
Older Adults ◽  
Regression Analysis ◽  
Hong Kong ◽  
Older Patients ◽  
Inappropriate Medication ◽  
Cross Sectional Study ◽  
Potentially Inappropriate Medication ◽  
Multivariable Logistic Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional

ObjectivesTo assess the prevalence of potentially inappropriate medication (PIM) use in Hong Kong older patients visiting general outpatient clinics (GOPCs) between 2006 and 2014 and to identify factors associated with PIM use among older adults visiting GOPCs in 2014.DesignCross-sectional study.SettingGOPC.ParticipantsTwo study samples were constructed including a total of 844 910 patients aged 65 and above from 2006 to 2014 and a cohort of 489 301 older patients in 2014.MeasurementsTwo subsets of the 2015 American Geriatrics Society Beers criteria—PIMs independent of diagnosis and PIMs due to drug–disease interactions—were used to estimate the prevalence of PIM use over 12 months. PIMs that were not included in the Hospital Authority drug formulary or with any specific restriction or exception in terms of indication, dose or therapy duration were excluded. Characteristics of PIM users and non-PIM users visiting GOPCs in 2014 were compared. Independent associations between patient variables and PIM use were assessed by stepwise multivariable logistic regression analysis.ResultsThe 12-month period prevalence of PIM use decreased from 55.56% (95% CI 55.39% to 55.72%) in 2006 to 47.51% (95% CI 47.37% to 47.65%) in 2014. In the multivariable regression analysis, the strongest factor associated with PIM use was the number of different drugs prescribed (adjusted OR, AOR 23.01, 95% CI 22.36 to 23.67). Being female (AOR 0.89, 95% CI 0.85 to 0.87 for males vs females) and having a greater number of GOPC visits (AOR 1.83, 95% CI 1.78 to 1.88) as well as more than six diagnoses (AOR 1.43, 95% CI 1.36 to 1.52) were associated with PIM use.ConclusionsThe overall prevalence of PIM use in older adults visiting GOPCs decreased from 2006 to 2014 in Hong Kong although the prevalence of PIM use was still high in 2014. Patients with female gender, a larger number of medications prescribed, more frequent visits to GOPCs, and more than six diagnoses were at higher risk for PIM use.

Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study

Pituitary ◽  
2021 ◽  
Author(s):  
Aysa Hacioglu ◽  
◽  
Aycan Gundogdu ◽  
Ufuk Nalbantoglu ◽  
Zuleyha Karaca ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiantong Zou ◽  
Xianghai Zhou ◽  
Linong Ji ◽  
Wenying Yang ◽  
Juming Lu ◽  
...  
Keyword(s):  
Early Onset ◽  
Population Based ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional ◽  
Onset Diabetes
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