Caffeic acid phenethyl ester-mediated Nrf2 activation and IκB kinase inhibition are involved in NFκB inhibitory effect: Structural analysis for NFκB inhibition

2010 ◽  
Vol 643 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Youna Lee ◽  
Dong-ha Shin ◽  
Ji-Hye Kim ◽  
Sungchae Hong ◽  
Daekyu Choi ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Kinase Inhibition ◽  
Iκb Kinase ◽  
Nrf2 Activation

Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells

2008 ◽  
Vol 128 (12) ◽  
pp. 1303-1307 ◽  
Author(s):  
Jae-Jun Song ◽  
Jae Gu Cho ◽  
Soon-Jae Hwang ◽  
Chang Gun Cho ◽  
Seok-Won Park ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Caffeic Acid ◽  
Middle Ear ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Human Middle Ear

scholarly journals Caffeic Acid Phenethyl Ester Inhibits UV-Induced MMP-1 Expression by Targeting Histone Acetyltransferases in Human Skin

2019 ◽  
Vol 20 (12) ◽  
pp. 3055 ◽  
Author(s):  
Eun Ju Shin ◽  
Seongin Jo ◽  
Hyo-kyoung Choi ◽  
Sungbin Choi ◽  
Sanguine Byun ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Human Skin ◽  
Ex Vivo ◽  
Bioactive Compound ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Dermal Fibroblasts ◽  
Regulatory Pathways ◽  
Skin Photoaging ◽  
Hdf Cells

Caffeic acid phenethyl ester (CAPE), a naturally occurring bioactive compound, displays anti-inflammatory, anti-carcinogenic, and anti-microbial effects. However, the effect of CAPE on skin photoaging is unknown. Herein, we investigated the inhibitory effect of CAPE against ultraviolet (UV) irradiation-mediated matrix metalloproteinase (MMP)-1 expression and its underlying molecular mechanism. CAPE treatment suppressed UV-induced MMP-1 levels in both human dermal fibroblasts (HDF) and human skin tissues. While CAPE did not display any significant effects against the upstream regulatory pathways of MMP-1, CAPE was capable of reversing UV-mediated epigenetic modifications. CAPE suppressed UV-induced acetyl-histone H3 (Lys9) as well as total lysine acetylation in HDF cells. Similarly, CAPE also attenuated UV-induced lysine acetylations in human skin tissues, suggesting that the CAPE-mediated epigenetic alterations can be recapitulated in ex vivo conditions. CAPE was found to attenuate UV-induced histone acetyltransferase (HAT) activity in HDF. Notably, CAPE was able to directly inhibit the activity of several HATs including p300, CREP-binding protein (CBP), and p300/CBP-associated factor (PCAF), further confirming that CAPE can function as an epigenetic modulator. Thus, our study suggests that CAPE maybe a promising agent for the prevention of skin photoaging via targeting HATs.

The inhibitory effect of propolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages

Phytomedicine ◽  
2002 ◽  
Vol 9 (6) ◽  
pp. 530-535 ◽  
Author(s):  
A. Rossi ◽  
A. Ligresti ◽  
R. Longo ◽  
A. Russo ◽  
F. Borrelli ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Cyclooxygenase Activity

Inhibitory Effect of Caffeic Acid Phenethyl Ester on Angiogenesis, Tumor Invasion, and Metastasis

2003 ◽  
Vol 51 (27) ◽  
pp. 7907-7912 ◽  
Author(s):  
Hui-Fen Liao ◽  
Yu-Ywan Chen ◽  
Jun-Jen Liu ◽  
Ming-Ling Hsu ◽  
Hui-Ju Shieh ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Tumor Invasion ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Invasion And Metastasis

Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats

2004 ◽  
Vol 339 (1-2) ◽  
pp. 65-75 ◽  
Author(s):  
Hüseyin Özyurt ◽  
Sadık Söğüt ◽  
Zeki Yıldırım ◽  
Levent Kart ◽  
Mustafa Iraz ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Lung Fibrosis ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect
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