A review on the role of Tau and Stathmin in gastric cancer metastasis

2021 ◽  
pp. 174312
Author(s):  
Bahareh Zarin ◽  
Azadeh Eshraghi ◽  
Farzaneh Zarifi ◽  
Shaghayegh Haghjooy Javanmard ◽  
Ismail Laher ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Metastasis

scholarly journals Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer

2019 ◽  
Vol 21 (1) ◽  
pp. 254 ◽  
Author(s):  
Yukiko Nishiguchi ◽  
Naohide Oue ◽  
Rina Fujiwara-Tani ◽  
Takamitsu Sasaki ◽  
Hitoshi Ohmori ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Metastasis ◽  
Ethyl Pyruvate ◽  
Signal Transduction Pathway ◽  
Fold Increase ◽  
Tanshinone Iia ◽  
Human Gastric Cancer ◽  
Cisplatin Chemoresistance

The role of metastasis-related genes in cisplatin (CDDP) chemoresistance in gastric cancer is poorly understood. Here, we examined the expression of four metastasis-related genes (namely, c-met, HMGB1, RegIV, PCDHB9) in 39 cases of gastric cancer treated with neoadjuvant therapy with CDDP or CDDP+5-fluorouracil and evaluated its association with CDDP responsiveness. Comparison of CDDP-sensitive cases with CDDP-resistant cases, the expression of c-met, HMGB1, and PCDHB9 was correlated with CDDP resistance. Among them, the expression of HMGB1 showed the most significant correlation with CDDP resistance in multivariate analysis. Treatment of TMK-1 and MKN74 human gastric cancer cell lines with ethyl pyruvate (EP) or tanshinone IIA (TAN), which are reported to inhibit HMGB1 signaling, showed a 4–5-fold increase in inhibition by CDDP. Treatment with EP or TAN also suppressed the expression of TLR4 and MyD88 in the HMGB1 signal transduction pathway and suppressed the activity of NFκB in both cell lines. These results suggest that the expression of these cancer metastasis-related genes is also related to anticancer drug resistance and that suppression of HMGB1 may be particularly useful for CDDP sensitization.

scholarly journals Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Jing Gao ◽  
Song Li ◽  
Qian Xu ◽  
Xue Zhang ◽  
Miao Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Metastasis ◽  
High Rate ◽  
Biological Information ◽  
Gastric Cancer Cells ◽  
Supportive Environment ◽  
Cell Components ◽  
Niche Formation ◽  
Mesenchymal Transformation

Gastric cancer has a high rate of metastasis, during which pre-metastatic niches (PMN) provide a supportive environment for the upcoming tumor cells. Exosomes are bilayer vesicles secreted by cells containing biological information that mediates communication between cells. Using exosomes, gastric cancer cells establish PMN remotely in multifarious perspectives, including immunosuppression, stroma remodeling, angiogenesis, mesothelial mesenchymal transformation, and organotropism. In turn, the cell components in PMN secrete exosomes that interact with each other and provide onco-promoting signals. In this review, we highlight the role of exosomes in PMN formation in gastric cancer and discuss their potential values in gastric cancer metastasis diagnosis, prevention, and treatment.

Role of RANTES and its receptor in gastric cancer metastasis

2011 ◽  
Vol 31 (3) ◽  
pp. 342-347 ◽  
Author(s):  
Zhixin Cao ◽  
Xiangshang Xu ◽  
Xuelai Luo ◽  
Li Li ◽  
Bin Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Metastasis

scholarly journals Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
An Ping ◽  
Su Zhendong ◽  
Qu Rongmei ◽  
Dai Jingxing ◽  
Chen Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Metastasis ◽  
Cancer Metastasis ◽  
Lymphatic System ◽  
Vascular System ◽  
Circulatory System ◽  
The World ◽  
Specific Tissue ◽  
Death Investigation

Gastric cancer is the fourth commonest cancer in the world and the second leading cause of cancer-related death. Investigation of gastric cancer metastasis is one of the hottest and major focuses in cancer research. Growing evidence manifested that primo vascular system (PVS) is a new kind of circulatory system beyond vascular and lymphatic system. Previous researches revealed that PVS is a specific tissue between endothelium and mesenchyme and is involved in cancer, especially in tumor metastasis and regeneration. In current study, we investigated the role of primo vessels in gastric cancer metastasis and its possible relationship to vascular vessels formation. Our results indicated that primo vessels were involved in gastric cancer metastasis. We observed blood vessel-mediated metastasis, primo vessel-mediated metastasis, and an intermediate state between them. We deduced that primo vessels may be precursors of blood vessels. These results possibly provided a thoroughly new theoretic development in cancer metastasis.

The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells

2009 ◽  
pp. 1-8
Author(s):  
Jing-Lei Qu ◽  
Xiu-Juan Qu ◽  
Ming-Fang Zhao ◽  
Yue-E Teng ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Ubiquitin Ligases ◽  
Jurkat T Cells ◽  
Induced Apoptosis

Role of vitamin C in gastric cancer

2018 ◽  
Vol 01 (1) ◽  
Author(s):  
Takalkar U Vidyadhar
Keyword(s):  
Gastric Cancer ◽  
Vitamin C ◽  
Gastric Juice ◽  
Oxidative Dna Damage ◽  
Preventive Measure ◽  
Dietary Factors ◽  
Preventive Strategy ◽  
H Pylori

Gastric cancer is a multifactorial disease with complex interplay of environmental and genetic factors. Helicobacter pylori (H. pylori) infestation has been identified as the most important etiological agent in the pathogenesis of gastric cancer. Also, the role of dietary factors that is low consumption of fruits and vegetables have been found to be associated with gastric cancer. Among the dietary factors, antioxidants especially vitamin C has been found to confer the strongest protection against gastric cancer. Its anti-proliferative and pro-apoptotic action has been suggested in vitro. Because of its antioxidant activity, it protects cells against oxidative DNA damage caused by toxic effects of reactive oxygen species. It also inhibits production of carcinogenic N-nitroso compound in the stomach. The person with H. pylori infection has low levels of vitamin C in their gastric juice and levels of vitamin C normalizes on eradication of H. pylori. Vitamin C levels are high in gastric mucosa and gastric juice, sometimes more than that of in plasma. But gastric pathological conditions cause lowered secretion of vitamin C into gastric juice. Effect of H. pylori on vitamin C in gastric juice is reversible and on eradication of H. pylori, it returns to normal level. Hence, eradication of H. pylori and chemoprevention with antioxidant supplementation will be an effective preventive strategy to reduce the incidence of gastric cancer and related mortality. Vitamin C and gastric cancer is an area of potential interest for researchers as a preventive measure. Keywords: Vitamin C, H. pylori, gastric cancer.

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