Advantages of neurofuzzy logic against conventional experimental design and statistical analysis in studying and developing direct compression formulations

2009 ◽  
Vol 38 (4) ◽  
pp. 325-331 ◽  
Author(s):  
Mariana Landín ◽  
R.C. Rowe ◽  
P. York
2019 ◽  
Author(s):  
Yasin Orooji ◽  
Fatemeh Noorisafa ◽  
Nahid Imami ◽  
Amir R. Chaharmahali

<p>Using experimental design and statistical analysis (½ Fractional Factorial Design), this study investigates the effect of different parameters in the membrane fabrication on the performance of nanocomposite PES/TiO<sub>2</sub> membrane. </p>


2007 ◽  
Vol 64 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Eniel David Cruz ◽  
José Edmar Urano de Carvalho ◽  
Rafaela Josemara Barbosa Queiroz

Seed coat impermeability to water occurs in many species, including Schizolobium amazonicum Huber ex Ducke. To promote germination in seeds with coat impermeability the use of sulphuric acid (H2SO4) is recommended. The objective of this study was to identify a better time for the scarification with sulphuric acid for S. amazonicum seeds. The effect of scarification with sulphuric acid for 20, 40 and 60 min on germination and speed germination was studied for seeds that were either sowed immediately after scarification or after a 24-hour period of immersion in water. Seeds were sown on a mix of sand and sawdust (1:1). The experimental design was completely randomized with four replications of 50 seeds. The statistical analysis of germination was carried out at six, nine, 12, 15, 18, 21 and 24 days after sowing, in a factorial scheme. For speed germination the means were compared by the Tukey test. There was an interaction between treatments to overcome dormancy and immersion time after scarification in most evaluations. Immersion in water accelerated the beginning of germination. All treatments to overcome dormancy promoted seed germination. However, scarification for 60 min, showed better germination, 92% when immediately sown and 86.5% when sown after 24 hours. Speed germination index was highest for scarified seeds for 60 min followed by immersion in water. Scarification for 60 min was the most efficient treatment to promote germination in S. amazonicum seeds.


2011 ◽  
Vol 12 (2) ◽  
pp. 155-184 ◽  
Author(s):  
Amro Abd al fattah Amara

ABSTRACT: Bacillus species are able to produce PHB, Proteases and Lipases. Bacillus subtilius, Bacillus pumilus, Bacillus therigienesis and Bacillus sp. were used. Plackett-Burman, Box-Behnken design and the Excel solver were used to optimize the production. The statistical analysis of the results proved insignificant relationship between the media compositions and the responses. The results clearly proved a competition between the production of PHB, Proteases and Lipases. Meanwhile systematic experimental design succeeded to minimize this competition. The maximum gained PHB in this study were 16.48 g/l/48 hr. In case of Proteases and Lipases were 534, and 22.56 Units/ml/48 h respectively. The strategies used in this study are recommended for simultaneous production of PHB and proteases. For some extend lipases produced too.


2020 ◽  
pp. 002367722090761 ◽  
Author(s):  
Florian Frommlet ◽  
Georg Heinze

The recent discussion on the reproducibility of scientific results is particularly relevant for preclinical research with animal models. Within certain areas of preclinical research, there exists the tradition of repeating an experiment at least twice to demonstrate replicability. If the results of the first two experiments do not agree, then the experiment might be repeated a third time. Sometimes data of one representative experiment are shown; sometimes data from different experiments are pooled. However, there are hardly any guidelines about how to plan for such an experimental design or how to report the results obtained. This article provides a thorough statistical analysis of pre-planned experimental replications as they are currently often applied in practice and gives some recommendations about how to improve on study design and statistical analysis.


2019 ◽  
Vol 152 (6) ◽  
pp. 775-781
Author(s):  
Sarah McBrien ◽  
Zachary Bailey ◽  
Jonathan Ryder ◽  
Paige Scholer ◽  
Geoffrey Talmon

AbstractObjectivesTo determine the strength of study design and outcomes in literature describing pathology education for medical students.MethodsA search was conducted for articles related to pathology education published over 45 years describing an educational intervention. The primary data collected included phase of education, domain of objectives, number of learners and institutions, type of intervention, use of a comparison/control group, randomization, and strength of statistical analysis.ResultsOf 655 articles, 54 (8%) met inclusion criteria. The majority (65%) reported experiences of 100 learners or fewer, and only one was multi-institutional. Only 46% used a comparison/control group. Statistical significance of results was not reported in 39%. None examined outcomes at a point distant from the educational intervention.ConclusionsMost studies describing pathology educational interventions are not of strong experimental design. Consumers of educational research should be cognizant of these potential weaknesses in educational studies.


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