scholarly journals Nanoporous microneedle arrays seamlessly connected to a drug reservoir for tunable transdermal delivery of memantine

2020 ◽  
Vol 150 ◽  
pp. 105331 ◽  
Author(s):  
Pieter Jan Vos ◽  
Nico Kuijt ◽  
Misli Kaya ◽  
Sanne Rol ◽  
Koen van der Maaden
Keyword(s):  
Transdermal Delivery ◽  
Drug Reservoir ◽  
Microneedle Arrays

scholarly journals Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 181
Author(s):  
Vahid Alimardani ◽  
Samira Sadat Abolmaali ◽  
Gholamhossein Yousefi ◽  
Zahra Rahiminezhad ◽  
Mehdi Abedi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Therapeutic Agents ◽  
Inorganic Nanoparticles ◽  
Microneedle Array ◽  
Wide Range ◽  
Microneedle Arrays

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.

scholarly journals Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis

2017 ◽  
Vol 265 ◽  
pp. 30-40 ◽  
Author(s):  
Patricia González-Vázquez ◽  
Eneko Larrañeta ◽  
Maelíosa T.C. McCrudden ◽  
Courtney Jarrahian ◽  
Annie Rein-Weston ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Transdermal Delivery ◽  
Potential Treatment ◽  
Microneedle Arrays

scholarly journals Microneedle-Based Delivery: An Overview of Current Applications and Trends

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 569 ◽  
Author(s):  
Antonio José Guillot ◽  
Ana Sara Cordeiro ◽  
Ryan F. Donnelly ◽  
M. Carmen Montesinos ◽  
Teresa M. Garrigues ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Transdermal Delivery ◽  
Safety Data ◽  
Manufacturing Processes ◽  
Systemic Effects ◽  
Subcutaneous Injections ◽  
Chemical Enhancers ◽  
Current State ◽  
Microneedle Arrays ◽  
Physical Treatments

Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed.

Development and Characterization of Starch/Gelatin Microneedle Arrays Loaded with Lecithin–Gelatin Nanoparticles of Losartan for Transdermal Delivery

2020 ◽  
Author(s):  
Ramón Andrés Pineda-Álvarez ◽  
María Josefa Bernad-Bernad ◽  
Isabel Marlen Rodríguez-Cruz ◽  
José Juan Escobar-Chávez
Keyword(s):  
Transdermal Delivery ◽  
Gelatin Nanoparticles ◽  
Microneedle Arrays

Dissolving Microneedle Arrays for Transdermal Delivery of Amphiphilic Vaccines

Small ◽  
2017 ◽  
Vol 13 (26) ◽  
pp. 1700164 ◽  
Author(s):  
Myunggi An ◽  
Haipeng Liu
Keyword(s):  
Transdermal Delivery ◽  
Microneedle Arrays

Piezoelectric inkjet coating of injection moulded, reservoir-tipped microneedle arrays for transdermal delivery

2019 ◽  
Vol 29 (8) ◽  
pp. 085004 ◽  
Author(s):  
Conor O’Mahony ◽  
Andrea Bocchino ◽  
Michael J Haslinger ◽  
Stefan Brandstätter ◽  
Helene Außerhuber ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Microneedle Arrays

Biodegradable and conductive chitosan–graphene quantum dot nanocomposite microneedles for delivery of both small and large molecular weight therapeutics

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 51934-51946 ◽  
Author(s):  
Richard Justin ◽  
Sabiniano Román ◽  
Dexin Chen ◽  
Ke Tao ◽  
Xiangshuai Geng ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Quantum Dot ◽  
Transdermal Delivery ◽  
Graphene Quantum Dot ◽  
Large Molecular Weight ◽  
Microneedle Arrays

Chitosan–graphene quantum dot nanocomposites are used in microneedle arrays for transdermal delivery of small and large molecular weight drugs.

Modelling transdermal delivery of high molecular weight drugs from microneedle systems

2007 ◽  
Vol 365 (1861) ◽  
pp. 2951-2967 ◽  
Author(s):  
Barrak Al-Qallaf ◽  
Diganta Bhusan Das ◽  
Daisuke Mori ◽  
Zhanfeng Cui
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Transdermal Delivery ◽  
Drug Transport ◽  
Functional Dependence ◽  
Scaling Analysis ◽  
Drug Permeability ◽  
Transport Behaviour ◽  
Microneedle Arrays

In the past few years, a number of microneedle designs have been proposed for transdermal drug delivery of high molecular weight drugs. However, most of them do not increase the drug permeability in skin significantly. In other cases, designs developed based on certain criteria (e.g. strength of the microneedles) have failed to meet other criteria (e.g. drug permeability in skin, throughputs of the drugs, etc.). It is obvious therefore that in order to determine the ‘optimum’ design of these microneedles, the effect of different factors (e.g. length of the microneedle, surface area of the patch, etc.) along with various transport properties of drug transport behaviour using microneedles should be determined accurately. Appropriate mathematical models for drug transport from these systems into skin have the potential to resolve some of these issues. To address this, a parametric analysis for transdermal delivery of a high molecular weight drug from a microneedle is presented in this paper. The simulations have allowed us to identify the significance of various factors that influence the drug delivery while designing microneedle arrays. A scaling analysis is also done which shows the functional dependence of drug concentration on other variables of skin and microneedle arrays.

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