scholarly journals Microneedle-Based Delivery: An Overview of Current Applications and Trends

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 569 ◽  
Author(s):  
Antonio José Guillot ◽  
Ana Sara Cordeiro ◽  
Ryan F. Donnelly ◽  
M. Carmen Montesinos ◽  
Teresa M. Garrigues ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Transdermal Delivery ◽  
Safety Data ◽  
Manufacturing Processes ◽  
Systemic Effects ◽  
Subcutaneous Injections ◽  
Chemical Enhancers ◽  
Current State ◽  
Microneedle Arrays ◽  
Physical Treatments

Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed.

Transdermal delivery of therapeutics through dissolvable gelatin/sucrose films coated on PEGDA microneedle arrays with improved skin permeability

2019 ◽  
Vol 7 (47) ◽  
pp. 7515-7524 ◽  
Author(s):  
Ya Gao ◽  
Mengmeng Hou ◽  
Ruihao Yang ◽  
Lei Zhang ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Permeability ◽  
Microneedle Arrays

Microneedles are primarily designed for enhancing transdermal drug delivery in a minimally invasive manner.

scholarly journals Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 181
Author(s):  
Vahid Alimardani ◽  
Samira Sadat Abolmaali ◽  
Gholamhossein Yousefi ◽  
Zahra Rahiminezhad ◽  
Mehdi Abedi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Therapeutic Agents ◽  
Inorganic Nanoparticles ◽  
Microneedle Array ◽  
Wide Range ◽  
Microneedle Arrays

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.

scholarly journals Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis

2017 ◽  
Vol 265 ◽  
pp. 30-40 ◽  
Author(s):  
Patricia González-Vázquez ◽  
Eneko Larrañeta ◽  
Maelíosa T.C. McCrudden ◽  
Courtney Jarrahian ◽  
Annie Rein-Weston ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Transdermal Delivery ◽  
Potential Treatment ◽  
Microneedle Arrays

scholarly journals Hydrogel-forming microneedle arrays: Potential for use in minimally-invasive lithium monitoring

2016 ◽  
Vol 102 ◽  
pp. 123-131 ◽  
Author(s):  
Eyman Eltayib ◽  
Aaron J. Brady ◽  
Ester Caffarel-Salvador ◽  
Patricia Gonzalez-Vazquez ◽  
Ahlam Zaid Alkilani ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Microneedle Arrays

scholarly journals Plasmonic photothermal microneedle arrays and single needles for minimally-invasive deep in-skin hyperthermia

2020 ◽  
Vol 8 (25) ◽  
pp. 5425-5433 ◽  
Author(s):  
Álvaro Cárcamo-Martínez ◽  
Brónach Mallon ◽  
Juan Domínguez-Robles ◽  
A. Sara Cordeiro ◽  
Maurizio Celentano ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Laser Irradiation ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Skin Model ◽  
Thickness Skin ◽  
Microneedle Arrays ◽  
First Time ◽  
Nir Laser ◽  
Deep Hyperthermia

We report, for the first time, crosslinked polymeric microneedle (MN) arrays and single needles (2 mm and 4.5 mm length) coated with gold nanorods (GnRs) to induce deep hyperthermia in a 3 mm-thickness skin model upon near infrared (NIR) laser irradiation.

Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives

2015 ◽  
Vol 113 (4) ◽  
pp. 698-716 ◽  
Author(s):  
Nripen Singh ◽  
Abhiram Arunkumar ◽  
Srinivas Chollangi ◽  
Zhijun George Tan ◽  
Michael Borys ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Manufacturing Processes ◽  
Future Perspectives ◽  
Current State

Anesthetic Implications of Natural Orifice Translumenal Endoscopic Surgery (NOTES) and Single-Incision Laparoscopic Surgery (SILS)

2018 ◽  
Author(s):  
Mark A. Gromski ◽  
Kai Matthes
Keyword(s):  
Laparoscopic Surgery ◽  
Minimally Invasive ◽  
Endoscopic Surgery ◽  
Single Incision ◽  
Single Incision Laparoscopic Surgery ◽  
Natural Orifice ◽  
Minimally Invasive Approach ◽  
Invasive Approach ◽  
Current State ◽  
Field Notes

This chapter introduces the concepts of natural orifice transluminal endoscopic surgery (NOTES) and single-incision laparoscopic surgery (SILS). The field of NOTES has evolved over the past decade, and this developmental framework is also outlined to help better understand the current state of the field. NOTES describes a minimally invasive approach to surgical diseases in which instruments are passed transluminally to achieve access to the desired body. SILS is a minimally invasive approach carried out as an extension of traditional laparoscopic surgery. The anesthetic implications of NOTES and SILS are explained, including potential complications that are unique to each. Finally, future directions in developmental endoscopy are discussed to give a sense of what types of procedures may become available or commonplace in the coming decade.

scholarly journals Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 534 ◽  
Author(s):  
Johanna Hettinga ◽  
Robert Carlisle
Keyword(s):  
Thermal Ablation ◽  
Influenza Pandemic ◽  
Vaccine Hesitancy ◽  
Vaccination Site ◽  
New Techniques ◽  
Diverse Range ◽  
Chemical Enhancers ◽  
Humoral And Cellular Immunity ◽  
Current State ◽  
Opening Up

In 2019, an ‘influenza pandemic’ and ‘vaccine hesitancy’ were listed as two of the top 10 challenges to global health by the WHO. The skin is a unique vaccination site, due to its immune-rich milieu, which is evolutionarily primed to respond to challenge, and its ability to induce both humoral and cellular immunity. Vaccination into this dermal compartment offers a way of addressing both of the challenges presented by the WHO, as well as opening up avenues for novel vaccine formulation and dose-sparing strategies to enter the clinic. This review will provide an overview of the diverse range of vaccination techniques available to target the dermal compartment, as well as their current state, challenges, and prospects, and touch upon the formulations that have been developed to maximally benefit from these new techniques. These include needle and syringe techniques, microneedles, DNA tattooing, jet and ballistic delivery, and skin permeabilization techniques, including thermal ablation, chemical enhancers, ablation, electroporation, iontophoresis, and sonophoresis.

The Current State of Minimally Invasive Living Donor Hepatectomy

2020 ◽  
Vol 7 (3) ◽  
pp. 169-179
Author(s):  
Dustin Carpenter ◽  
Sulemon Chaudhry ◽  
Benjamin Samstein
Keyword(s):  
Minimally Invasive ◽  
Living Donor ◽  
Donor Hepatectomy ◽  
Current State ◽  
Living Donor Hepatectomy
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