Analysis of clinical features and prognostic factors in Chinese patients with rheumatic diseases in an intensive care unit

Abstract Background Little is known in distinguishing clinical features and outcomes between coronavirus disease-19 (COVID-19) and influenza (FLU). Materials/methods Retrospective, single-centre study including patients with COVID-19 or FLU pneumonia admitted to the Intensive care Unit (ICU) of Policlinico Umberto I (Rome). Aims were: (1) to assess clinical features and differences of patients with COVID-19 and FLU, (2) to identify clinical and/or laboratory factors associated with FLU or COVID-19 and (3) to evaluate 30-day mortality, bacterial superinfections, thrombotic events and invasive pulmonary aspergillosis (IPA) in patients with FLU versus COVID-19. Results Overall, 74 patients were included (19, 25.7%, FLU and 55, 74.3%, COVID-19), median age 67 years (58–76). COVID-19 patients were more male (p = 0.013), with a lower percentage of COPD (Chronic Obstructive Pulmonary Disease) and chronic kidney disease (CKD) (p = 0.001 and p = 0.037, respectively) than FLU. SOFA score was higher (p = 0.020) and lymphocytes were significantly lower in FLU than in COVID-19 [395.5 vs 770.0 cells/mmc, p = 0.005]. At multivariable analysis, male sex (OR 6.1, p < 0.002), age > 65 years (OR 2.4, p = 0.024) and lymphocyte count > 725 cells/mmc at ICU admission (OR 5.1, p = 0.024) were significantly associated with COVID-19, whereas CKD and COPD were associated with FLU (OR 0.1 and OR 0.16, p = 0.020 and p < 0.001, respectively). No differences in mortality, bacterial superinfections and thrombotic events were observed, whereas IPA was mostly associated with FLU (31.5% vs 3.6%, p = 0.0029). Conclusions In critically ill patients, male sex, age > 65 years and lymphocytes > 725 cells/mmc are related to COVID-19. FLU is associated with a significantly higher risk of IPA than COVID-19.

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Clinical Features and Prognosis of Adult-onset Still’s Disease: 61 Cases from China

The Journal of Rheumatology ◽

10.3899/jrheum.080365 ◽

2009 ◽

Vol 36 (5) ◽

pp. 1026-1031 ◽

Cited By ~ 48

Author(s):

TING ZENG ◽

YU-QIONG ZOU ◽

MEI-FANG WU ◽

CHENG-DE YANG

Keyword(s):

Prognostic Factors ◽

Clinical Features ◽

Chinese Patients ◽

Adult Onset Still’S Disease ◽

Disease Course ◽

Adult Onset ◽

Still’S Disease ◽

Laboratory Findings ◽

Still's Disease ◽

Adult Onset Still's Disease

Objective.To describe the onset, clinical features, prognostic factors, and treatment of adult-onset Still’s disease (AOSD) in cases from China.Methods.Sixty-one Chinese patients with AOSD were analyzed retrospectively.Results.Common clinical features were fever (100.0%), rash (88.5%), and arthritis (82.0%). The laboratory findings were as follows: leukocytosis (83.6%), increased erythrocyte sedimentation rate (100.0%), elevated transaminase concentrations (23.0%), elevated ferritin levels (79.6%), negative antinuclear antibody (88.5%), and negative rheumatoid factor (88.5%). Of the 61 patients, 44.3% exhibited a monocyclic disease pattern, 29.5% experienced disease relapse at least once, 16.4% exhibited chronic articular course, and 9.8% died; most deaths were due to pulmonary infection and respiratory failure. Based on the disease course, we divided the 61 patients into 2 groups: those with favorable outcome (cyclic disease course, n = 45) and unfavorable outcome (chronic disease course or death, n = 16). We analyzed the prognostic factors for the 2 groups, and found that pleuritis, interstitial pneumonia, elevated ferritin levels, and failure of fever to subside after 3 days of prednisolone at 1 mg/kg/day were unfavorable prognostic factors for patients with AOSD.Conclusion.Patients with AOSD had complex symptoms with no specific laboratory findings. Our results indicate that AOSD is not a relatively benign disease, especially in cases that are refractory to high doses of prednisone.

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Mortality prognostic factors of patients with systemic autoimmune diseases admitted to an intensive care unit

European Journal of Internal Medicine ◽

10.1016/j.ejim.2013.08.289 ◽

2013 ◽

Vol 24 ◽

pp. e114

Author(s):

P.I. Doti ◽

S. Fernandez ◽

E. Coloma ◽

O. Escoda ◽

I. Rodriguez-Pintó ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Prognostic Factors ◽

Autoimmune Diseases ◽

Systemic Autoimmune Diseases

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A STUDY ON ETIOLOGY, CLINICAL FEATURES, MANAGEMENT AND OUTCOME OF ACUTE LIVER FAILURE IN PAEDIATRIC INTENSIVE CARE UNIT OF BURDWAN MEDICAL COLLEGE

10.36106/ijsr/5133342 ◽

2021 ◽

pp. 54-55

Author(s):

Sankar narayan mishra ◽

Kaustav nayek ◽

Tamal kayal ◽

Debarshi Jana

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Liver Failure ◽

Acute Liver Failure ◽

Pediatric Intensive Care Unit ◽

Clinical Features ◽

Paediatric Intensive Care Unit ◽

Pediatric Intensive Care ◽

Medical College ◽

Bacterial Peritonitis

Introduction: In the present study, etiology, important clinical features, management and outcome of acute liver failure in children admitted in Pediatric Intensive Care Unit (PICU) of BURDWAN MEDICALCOLLEGE, WB are studied. Aims and objectives:To study different clinical features among those children having acute liver failure. I. To study the management and outcome of those children with acute liver failure in the Pediatric Intensive Care Unit. Material and methods: Pediatric Intensive Care Unit of BURDWAN MEDICALCOLLEGE, WB. 1 Year [December 2019 to November 2020]. Patients from 3months of age to 12years of age are eligible for enrolment if they meet the following criteria. Conclusion: Present study showed that cerebral edema was signicantly associated with mortality whereas AKI and spontaneous bacterial peritonitis were not signicantly related with mortality. Mean TSB and Prothrobin Time were higher but mean serum albumin was lower in those cases that had died.

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