Important increase in breast cancer incidence in South Asian women

AbstractBreast cancer is the most common malignancy among women globally. Development of a reliable plasma biomarker panel might serve as a non-invasive and cost-effective means for population-based screening of the disease. Transcriptomic profiling of breast tumour, paired normal and apparently normal tissues, followed by validation of the shortlisted genes using TaqMan® Low density arrays and Quantitative real-time PCR was performed in South Asian women. Fifteen candidate protein markers and 3 candidate epigenetic markers were validated first in primary breast tumours and then in plasma samples of cases [N = 202 invasive, 16 DCIS] and controls [N = 203 healthy, 37 benign] using antibody array and methylation specific PCR. Diagnostic efficiency of single and combined markers was assessed. Combination of 6 protein markers (Adipsin, Leptin, Syndecan-1, Basic fibroblast growth factor, Interleukin 17B and Dickopff-3) resulted in 65% sensitivity and 80% specificity in detecting breast cancer. Multivariate diagnostic analysis of methylation status of SOSTDC1, DACT2, WIF1 showed 100% sensitivity and up to 91% specificity in discriminating BC from benign and controls. Hence, combination of SOSTDC1, DACT2 and WIF1 was effective in differentiating breast cancer [non-invasive and invasive] from benign diseases of the breast and healthy individuals and could help as a complementary diagnostic tool for breast cancer.

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BMI change and abdominal girth as risk factors of breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e13082 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e13082-e13082

Author(s):

Yusuke Suzuki ◽

Hiroko Tsunoda ◽

Takeshi Kimura ◽

Hideko Yamauchi

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Cancer Screening ◽

Postmenopausal Women ◽

Cancer Incidence ◽

Breast Cancer Incidence ◽

Develop Breast Cancer ◽

Asian Women ◽

Abdominal Girth ◽

High Hba1c

e13082 Background: While obesity is considered the risk factors of breast cancer, Asian women are tends to be lower BMI compared with Western populations and there are not much reports that studied association between obesity and risk of breast cancer in Asian women. In this study, we analyzed the associations of breast cancer incidence and body mass index at age 18-20 (BMI 18-20y), BMI at research entry (BMI at entry), change of the BMI from BMI 18-20y to BMI at entry (BMI change), abdominal girth at research entry (AG), HbA1c [N] at research entry (HbA1c). Methods: We used data of the women who had undergone medical check-ups and opportunistic breast cancer screening at least twice at the Center for Preventive Medicine of St. Luke’s International Hospital between April 1, 2005 and March 31, 2014. Statistical analysis was done by using multivariate Cox proportional hazards model to investigate the hazard ratio (HR) at 95% confidence intervals (95% CI). Results: In this 10 year period, 30,109 women (20,043 women were premenopausal and 10,066 women were postmenopausal women) received opportunistic breast cancer screening at least twice. After analysis of 131656.6 person-years follow up during 10 years, 325 initial breast cancer cases were identified 202 cases in premenopausal women, and 123 cases in postmenopausal women. Among postmenopausal women, BMI change and AG were positively associated with breast cancer incidence. Women whose BMI change were major gain group (> +5.0) were significantly likely to develop breast cancer compared with stable group (BMI change were between -2.5 to +2.5) [HR: 1.902 (95% CI = 1.202-3.009)]. Large AG ( > 90cm) was significant risk to develop breast cancer versus less than 70cm [HR: 2.500 (95% CI = 1.091-5.730)]. In the analysis classified BMI18-20y more and less than 20 kg/m2, large BMI18-20y ( > 20 kg/m2) postmenopausal women with high HbA1c ( > 6.5) was more likely to develop breast cancer compared with low HbA1c ( < 5.5) [HR: 3.325(95% CI = 1.307-8.460)]. Conclusions: Increase of BMI after age of 18-20 years and large AG in postmenopausal women have positive association with breast cancer development. High HbA1c women whose BMI18-20y was over 20 kg/m2 are significantly to develop breast cancer.

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Breast cancer survivorship and South Asian Women: understanding about the follow-up care plan and perspectives and preferences for information post treatment

Current Oncology ◽

10.3747/co.20.1066 ◽

2013 ◽

Vol 20 (2) ◽

Cited By ~ 12

Author(s):

S. Singh-Carlson ◽

F. Wong ◽

L. Martin ◽

S.K.A. Nguyen

Keyword(s):

Breast Cancer ◽

Cancer Survivorship ◽

South Asian ◽

Post Treatment ◽

Care Plan ◽

Asian Women ◽

South Asian Women ◽

Breast Cancer Survivorship ◽

Follow Up Care

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South Asian women have lower incidence of breast cancer

Nursing Standard ◽

10.7748/ns.19.43.19.s23 ◽

2005 ◽

Vol 19 (43) ◽

pp. 19-19

Keyword(s):

Breast Cancer ◽

South Asian ◽

Lower Incidence ◽

Asian Women ◽

South Asian Women

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A population-based study of ethnicity and breast cancer stage at diagnosis in Ontario

Current Oncology ◽

10.3747/co.22.2359 ◽

2015 ◽

Vol 22 (2) ◽

pp. 97 ◽

Cited By ~ 14

Author(s):

O.M. Ginsburg ◽

H.D. Fischer ◽

B.R. Shah ◽

L. Lipscombe ◽

L. Fu ◽

...

Keyword(s):

Breast Cancer ◽

General Population ◽

South Asian ◽

Chinese Women ◽

Stage I ◽

Stage Ii ◽

Asian Women ◽

Cancer Stage ◽

Stage At Diagnosis ◽

South Asian Women

BackgroundBreast cancer stage at diagnosis is an important predictor of survival. Our goal was to compare breast cancer stage at diagnosis (by American Joint Committee on Cancer criteria) in Chinese and South Asian women with stage at diagnosis in the remaining general population in Ontario.MethodsWe used the Ontario population-based cancer registry to identify all women diagnosed with breast cancer during 2005–2010, and we applied a validated surname algorithm to identify South Asian and Chinese women. We used logistic regression to compare, for Chinese or South Asian women and for the remaining general population, the frequency of diagnoses at stage ii compared with stage i and stages ii–iv compared with stage i.ResultsThe registry search identified 1304 Chinese women, 705 South Asian women, and 39,287 women in the remaining general population. The Chinese and South Asian populations were younger than the remaining population (mean: 54, 57, and 61 years respectively). Adjusted for age, South Asian women were more often diagnosed with breast cancer at stage ii than at stage i [odds ratio (or): 1.28; 95% confidence interval (ci): 1.08 to 1.51] or at stages ii-iv than at stage i (or: 1.27; 95% ci: 1.08 to 1.48); Chinese women were less likely to be diagnosed at stage ii than at stage i (or: 0.82; 95% ci: 0.72 to 0.92) or at stages ii-iv than at stage i (or: 0.73; 95% ci: 0.65 to 0.82).ConclusionsBreast cancers were diagnosed at a later stage in South Asian women and at an earlier stage in Chinese women than in the remaining population. A more detailed analysis of ethnocultural factors influencing breast screening uptake, retention, and care-seeking behavior might be needed to help inform and evaluate tailored health promotion activities.

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