scholarly journals Identification and validation of plasma biomarkers for diagnosis of breast cancer in South Asian women

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Thangarajan Rajkumar ◽  
Sathyanarayanan Amritha ◽  
Veluswami Sridevi ◽  
Gopisetty Gopal ◽  
Kesavan Sabitha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
South Asian ◽  
Effective Means ◽  
Methylation Status ◽  
Asian Women ◽  
Antibody Array ◽  
Diagnostic Efficiency ◽  
South Asian Women ◽  
Protein Markers ◽  
Non Invasive

AbstractBreast cancer is the most common malignancy among women globally. Development of a reliable plasma biomarker panel might serve as a non-invasive and cost-effective means for population-based screening of the disease. Transcriptomic profiling of breast tumour, paired normal and apparently normal tissues, followed by validation of the shortlisted genes using TaqMan® Low density arrays and Quantitative real-time PCR was performed in South Asian women. Fifteen candidate protein markers and 3 candidate epigenetic markers were validated first in primary breast tumours and then in plasma samples of cases [N = 202 invasive, 16 DCIS] and controls [N = 203 healthy, 37 benign] using antibody array and methylation specific PCR. Diagnostic efficiency of single and combined markers was assessed. Combination of 6 protein markers (Adipsin, Leptin, Syndecan-1, Basic fibroblast growth factor, Interleukin 17B and Dickopff-3) resulted in 65% sensitivity and 80% specificity in detecting breast cancer. Multivariate diagnostic analysis of methylation status of SOSTDC1, DACT2, WIF1 showed 100% sensitivity and up to 91% specificity in discriminating BC from benign and controls. Hence, combination of SOSTDC1, DACT2 and WIF1 was effective in differentiating breast cancer [non-invasive and invasive] from benign diseases of the breast and healthy individuals and could help as a complementary diagnostic tool for breast cancer.

Predictors in breast cancer screening behaviors of South Asian women

2014 ◽  
Vol 12 (2) ◽  
pp. e229-e233 ◽  
Author(s):  
Jananie C Perera ◽  
Vimukthini Peiris ◽  
Dakshitha P Wickramasinghe ◽  
Ishan De Zoysa
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
South Asian ◽  
Asian Women ◽  
South Asian Women ◽  
Screening Behaviors

Important increase in breast cancer incidence in South Asian women

2012 ◽  
Vol 38 (5) ◽  
pp. 463 ◽  
Author(s):  
Anne Stotter ◽  
Olive Kearins ◽  
Jacqui Jenkins ◽  
Adrienne Catcheside ◽  
Hanna Blackledge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
South Asian ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Asian Women ◽  
South Asian Women

scholarly journals Survival from breast cancer among South Asian and non-South Asian women resident in South East England

2003 ◽  
Vol 89 (3) ◽  
pp. 508-512 ◽  
Author(s):  
I dos Santos Silva ◽  
P Mangtani ◽  
B L De Stavola ◽  
J Bell ◽  
M Quinn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
South Asian ◽  
Asian Women ◽  
South Asian Women ◽  
South East England

scholarly journals A population-based study of ethnicity and breast cancer stage at diagnosis in Ontario

2015 ◽  
Vol 22 (2) ◽  
pp. 97 ◽  
Author(s):  
O.M. Ginsburg ◽  
H.D. Fischer ◽  
B.R. Shah ◽  
L. Lipscombe ◽  
L. Fu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
General Population ◽  
South Asian ◽  
Chinese Women ◽  
Stage I ◽  
Stage Ii ◽  
Asian Women ◽  
Cancer Stage ◽  
Stage At Diagnosis ◽  
South Asian Women

BackgroundBreast cancer stage at diagnosis is an important predictor of survival. Our goal was to compare breast cancer stage at diagnosis (by American Joint Committee on Cancer criteria) in Chinese and South Asian women with stage at diagnosis in the remaining general population in Ontario.MethodsWe used the Ontario population-based cancer registry to identify all women diagnosed with breast cancer during 2005–2010, and we applied a validated surname algorithm to identify South Asian and Chinese women. We used logistic regression to compare, for Chinese or South Asian women and for the remaining general population, the frequency of diagnoses at stage ii compared with stage i and stages ii–iv compared with stage i.ResultsThe registry search identified 1304 Chinese women, 705 South Asian women, and 39,287 women in the remaining general population. The Chinese and South Asian populations were younger than the remaining population (mean: 54, 57, and 61 years respectively). Adjusted for age, South Asian women were more often diagnosed with breast cancer at stage ii than at stage i [odds ratio (or): 1.28; 95% confidence interval (ci): 1.08 to 1.51] or at stages ii-iv than at stage i (or: 1.27; 95% ci: 1.08 to 1.48); Chinese women were less likely to be diagnosed at stage ii than at stage i (or: 0.82; 95% ci: 0.72 to 0.92) or at stages ii-iv than at stage i (or: 0.73; 95% ci: 0.65 to 0.82).ConclusionsBreast cancers were diagnosed at a later stage in South Asian women and at an earlier stage in Chinese women than in the remaining population. A more detailed analysis of ethnocultural factors influencing breast screening uptake, retention, and care-seeking behavior might be needed to help inform and evaluate tailored health promotion activities.

Phyto-oestrogen Intake and Breast Cancer Risk in South Asian Women in England: Findings from a Population-based Case–Control Study

2004 ◽  
Vol 15 (8) ◽  
pp. 805-818 ◽  
Author(s):  
Isabel dos Santos Silva ◽  
Punam Mangtani ◽  
Valerie McCormack ◽  
Dee Bhakta ◽  
Anthony J McMichael ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
South Asian ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Asian Women ◽  
South Asian Women ◽  
Control Study
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