The prognostic impact of mode of detection of axillary metastases for women with invasive breast cancer: A retrospective observational study

XIAP, the most potent inhibitor of cell death pathways, is linked to chemotherapy resistance and tumor aggressiveness. Currently, multiple XIAP-targeting agents are in clinical trials. However, the characterization of XIAP expression in relation to clinicopathological variables in large clinical series of breast cancer is lacking. We retrospectively analyzed non-metastatic, non-inflammatory, primary, invasive breast cancer samples for XIAP mRNA (n = 2341) and protein (n = 367) expression. XIAP expression was analyzed as a continuous value and correlated with clinicopathological variables. XIAP mRNA expression was heterogeneous across samples and significantly associated with younger patients’ age (≤50 years), pathological ductal type, lower tumor grade, node-positive status, HR+/HER2- status, and PAM50 luminal B subtype. Higher XIAP expression was associated with shorter DFS in uni- and multivariate analyses in 909 informative patients. Very similar correlations were observed at the protein level. This prognostic impact was significant in the HR+/HER2- but not in the TN subtype. Finally, XIAP mRNA expression was associated with lower pCR rate to anthracycline-based neoadjuvant chemotherapy in both uni- and multivariate analyses in 1203 informative patients. Higher XIAP expression in invasive breast cancer is independently associated with poorer prognosis and resistance to chemotherapy, suggesting the potential therapeutic benefit of targeting XIAP.

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Fat-enlarged axillary lymph nodes are associated with node-positive breast cancer in obese patients

Breast Cancer Research and Treatment ◽

10.1007/s10549-021-06262-z ◽

2021 ◽

Author(s):

Roberta M. diFlorio-Alexander ◽

Qingyuan Song ◽

Dennis Dwan ◽

Judith A. Austin-Strohbehn ◽

Kristen E. Muller ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Invasive Breast Cancer ◽

Breast Mri ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Obese Women ◽

Axillary Metastases ◽

Node Positive ◽

Positive Breast Cancer

Abstract Purpose Obesity associated fat infiltration of organ systems is accompanied by organ dysfunction and poor cancer outcomes. Obese women demonstrate variable degrees of fat infiltration of axillary lymph nodes (LNs), and they are at increased risk for node-positive breast cancer. However, the relationship between enlarged axillary nodes and axillary metastases has not been investigated. The purpose of this study is to evaluate the association between axillary metastases and fat-enlarged axillary nodes visualized on mammograms and breast MRI in obese women with a diagnosis of invasive breast cancer. Methods This retrospective case–control study included 431 patients with histologically confirmed invasive breast cancer. The primary analysis of this study included 306 patients with pre-treatment and pre-operative breast MRI and body mass index (BMI) > 30 (201 node-positive cases and 105 randomly selected node-negative controls) diagnosed with invasive breast cancer between April 1, 2011, and March 1, 2020. The largest visible LN was measured in the axilla contralateral to the known breast cancer on breast MRI. Multivariate logistic regression models were used to assess the association between node-positive status and LN size adjusting for age, BMI, tumor size, tumor grade, tumor subtype, and lymphovascular invasion. Results A strong likelihood of node-positive breast cancer was observed among obese women with fat-expanded lymph nodes (adjusted OR for the 4th vs. 1st quartile for contralateral LN size on MRI: 9.70; 95% CI 4.26, 23.50; p < 0.001). The receiver operating characteristic curve for size of fat-enlarged nodes in the contralateral axilla identified on breast MRI had an area under the curve of 0.72 for predicting axillary metastasis, and this increased to 0.77 when combined with patient and tumor characteristics. Conclusion Fat expansion of axillary lymph nodes was associated with a high likelihood of axillary metastases in obese women with invasive breast cancer independent of BMI and tumor characteristics.

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Patient-related Risk Factors for Nausea and Vomiting with Standard Antiemetics in Patients with Breast Cancer Receiving Anthracycline-based Chemotherapy: A Retrospective Observational Study

Clinical Therapeutics ◽

10.1016/j.clinthera.2018.10.004 ◽

2018 ◽

Vol 40 (12) ◽

pp. 2170-2179 ◽

Cited By ~ 1

Author(s):

Hitoshi Kawazoe ◽

Akari Murakami ◽

Michiko Yamashita ◽

Kanako Nishiyama ◽

Kana Kobayashi-Taguchi ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Observational Study ◽

Nausea And Vomiting ◽

Retrospective Observational Study ◽

Related Risk

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Fat-enlarged Axillary Lymph Nodes are Associated with Node-Positive Breast Cancer in Obese Patients

10.1101/2021.02.17.20246504 ◽

2021 ◽

Author(s):

Roberta M. diFlorio-Alexander ◽

Qingyuan Song ◽

Dennis Dwan ◽

Judith A. Austin-Strohbehn ◽

Kristen E. Muller ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Invasive Breast Cancer ◽

Breast Mri ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Obese Women ◽

Axillary Metastases ◽

Node Positive ◽

Positive Breast Cancer

AbstractPurposeObesity-associated fat infiltration of organ systems is accompanied by organ dysfunction and poor cancer outcomes. Obese women demonstrate variable degrees of fat infiltration of axillary lymph nodes (LNs), and they are at increased risk for node-positive breast cancer. However, the relationship between enlarged axillary nodes and axillary metastases has not been investigated. The purpose of this study is to evaluate the association between axillary metastases and fat-enlarged axillary nodes visualized on mammograms and breast MRI in obese women with a diagnosis of invasive breast cancer.MethodsThis retrospective case-control study included 431 patients with histologically confirmed invasive breast cancer. The primary analysis of this study included 306 patients with pre-operative MRI and body mass index (BMI) > 30 (201 node-positive cases and 105 randomly selected node-negative controls) diagnosed with invasive breast cancer diagnosed between April 1, 2011, and March 1, 2020. The largest visible LN was measured in the axilla contralateral to the known breast cancer on breast MRI. Multivariate logistic regression models were used to assess the association between node-positive status and LN size adjusting for age, BMI, tumor size, tumor grade, tumor subtype, and lymphovascular invasion.ResultsA strong likelihood of node-positive breast cancer was observed among obese women with fat-expanded lymph nodes (adjusted OR for the 4th vs. 1st quartile for contralateral LN size on MRI: 9.70; 95% CI: 4.26, 23.50; p < 0.001). The receiver operating characteristic curve for size of fat-enlarged nodes in the contralateral axilla identified on breast MRI had an area under the curve of 0.72 for predicting node-positive breast cancer and this increased to 0.80 when combined with patient and tumor characteristics.ConclusionFat expansion of axillary lymph nodes was associated with a high likelihood of axillary metastases in obese women with invasive breast cancer independent of BMI and tumor characteristics.

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Effect of eribulin on patients with metastatic breast cancer: multicenter retrospective observational study in Taiwan

Breast Cancer Research and Treatment ◽

10.1007/s10549-018-4778-y ◽

2018 ◽

Vol 170 (3) ◽

pp. 583-591 ◽

Cited By ~ 3

Author(s):

Kun-Ming Rau ◽

Fu Ou-Yang ◽

Ta-Chung Chao ◽

Yao-Lung Kuo ◽

Tsui-Fen Cheng ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Observational Study ◽

Metastatic Breast ◽

Retrospective Observational Study

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Impact of persistent anaemia on mortality in patients hospitalised with acute pulmonary embolism: an Australian retrospective observational study

BMJ Open ◽

10.1136/bmjopen-2018-027112 ◽

2019 ◽

Vol 9 (4) ◽

pp. e027112

Author(s):

Wallace Chow ◽

Christopher Wong ◽

Jerrett K Lau ◽

Vincent Chow ◽

Leonard Kritharides ◽

...

Keyword(s):

Pulmonary Embolism ◽

Observational Study ◽

Acute Pulmonary Embolism ◽

Retrospective Observational Study ◽

Study Cohort ◽

Prognostic Impact ◽

Tertiary Referral Centre ◽

Baseline Haemoglobin ◽

The Impact ◽

Acute Pe

ObjectivesAnaemia is associated with increased mortality in acute pulmonary embolism (PE) patients. However, prior studies have not examined the prognostic impact of trends in plasma haemoglobin during admission. This study investigates the impact of changes in haemoglobin level on mortality during hospital stay in acute PE.Study designA retrospective observational study.SettingTertiary-referral centre in Australia.ParticipantsConsecutive patients from 2000 to 2012 admitted with confirmed acute PE were identified from a dedicated PE database. Haemoglobin levels on days 1, 3–4, 5–6 and 7 of admission were retrieved. Patients without both baseline haemoglobin and subsequent haemoglobin levels were excluded (n=327), leaving 1099 patients as the study cohort. Anaemia was defined as haemoglobin <130 g/L for men and <120 g/L for women. There were 576 patients without anaemia throughout admission, 65 with transient anaemia (anaemic on day 1, but subsequently normalised during admission), 122 with acquired anaemia (normal on day 1 but developed anaemia during admission) and 336 with persistent anaemia. A total of 71 patients received blood transfusion during admission.Main outcome measure6-month mortality was tracked from a state-wide death database and analysed using multivariable modelling.ResultsAfter adjusting for transfusion, patietns with persistent anaemia had a significantly increased 6-month mortality risk (adjusted HR 1.97, 95% CI 1.26 to 3.09, p=0.003) compared with patients without anaemia. There was no difference in mortality between patients with transient or acquired anaemia and patients without anaemia.ConclusionAmong patients who had anaemia during their admission for acute PE, only the subgroup with persistent anaemia demonstrated worse outcomes.

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